A5043332091- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Kruppel-like factors research
- Cancer-related gene regulation
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cerebrovascular and Carotid Artery Diseases
- Immune cells in cancer
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Mesenchymal stem cell research
- Urinary and Genital Oncology Studies
- Mycobacterium research and diagnosis
- Renal and Vascular Pathologies
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing Loss and Rehabilitation
- Cardiovascular Issues in Pregnancy
- MicroRNA in disease regulation
- Stroke Rehabilitation and Recovery
- MRI in cancer diagnosis
- Vitamin D Research Studies
Southwest Medical University
2021-2025
University Medical Centre Mannheim
2023-2025
Heidelberg University
2023-2025
University Hospital Heidelberg
2023-2025
Chiang Mai University
2021-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Pingliang People's Hospital
2023
Army Medical University
2019-2023
Chongqing Medical University
2023
<h3>Importance</h3> For patients with large vessel occlusion strokes, it is unknown whether endovascular treatment alone compared intravenous thrombolysis plus (standard treatment) can achieve similar functional outcomes. <h3>Objective</h3> To investigate thrombectomy noninferior to alteplase followed by for achieving independence at 90 days among stroke. <h3>Design, Setting, and Participants</h3> Multicenter, randomized, noninferiority trial conducted 33 stroke centers in China. Patients (n...
This study aimed to analyze the impact of baseline posterior circulation Acute Stroke Prognosis Early Computed Tomography Score (pc-ASPECTS) on efficacy and safety endovascular therapy (EVT) for patients with acute basilar artery occlusion. The BASILAR was a nationwide prospective registry consecutive symptomatic radiologically confirmed occlusion within 24 hours symptom onset. We estimated effect standard medical alone (SMT group) versus SMT plus EVT (EVT documented pc-ASPECTS noncontrast...
Background: Intracerebral hemorrhage (ICH), a devastating form of stroke, is characterized by elevated morbidity and mortality rates. Neuroinflammation common occurrence following ICH. Mesenchymal stem cells (MSCs) have exhibited potential in treating brain diseases due to their anti-inflammatory properties. However, the therapeutic efficacy MSCs limited intense inflammatory response at transplantation site Hence, enhancing function transplanted holds considerable promise as strategy for...
Abstract Background Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered stress, with endothelial being one of its pathophysiological mechanisms. However, the precise molecular mechanism underlying interaction between cells cardiomyocytes during TTC remains unclear. This study reveals that exosomal miRNAs derived from exposed to catecholamine contribute ion channel in setting TTC. Methods Human-induced pluripotent...
Intracerebral hemorrhage (ICH) is a most serious type of hemorrhagic stroke with continuously rising incidence globally, without effective cure available. The underlying mechanisms driving brain injury are complex and include inflammation, oxidative stress, glutamate excitotoxicity, membrane damage, lipid peroxidation, ferroptosis other cellular death modes. Hematoma clearance the key to limit damage foster recovery process. quest for ICH remedies continuing strategically evolving expansion...
Liver fibrosis is an inadequate response to tissue stress, with reactive oxygen species (ROS) overproduction in activated hepatic stellate cells (aHSCs). Bromodomain-containing protein 4 (BRD4) was found be upregulated aHSCs and has been identified as effective target for the treatment of liver fibrosis. However, inhibition BRD4 traditional kinase inhibitors achieved only limited success because its low therapeutic efficiency. Furthermore, exact mechanism by which regulates remains unclear...
Abstract Background Intracerebral hemorrhage (ICH) is a severe brain-injured disease accompanied by cerebral edema, inflammation, and subsequent neurological deficits. Mesenchymal stem cells (MSCs) transplantation has been used as neuroprotective therapy in nervous system diseases because of its anti-inflammatory effect. Nevertheless, the biological characteristics transplanted MSCs, including survival rate, viability, effectiveness, are restricted inflammatory response after ICH. Therefore,...
To investigate the performance of histogram features non-Gaussian diffusion metrics for diagnosing muscle invasion and histological grade in bladder cancer (BCa).
RNA-binding proteins (RBPs) have been shown to be involved in posttranscriptional regulation, which plays an important role the pathophysiology of intracerebral hemorrhage (ICH). Peroxiredoxin 1 (Prdx1), RBP, regulating inflammation and apoptosis. On basis that apoptosis may contribute ICH-induced brain injury, this study, we used ICH models coupled with vitro experiments, investigate mechanism Prdx1 by acting as RBP after ICH. We first found was significantly up-regulated response injury...
Circulating factors associated with aging have been shown to be involved in the development of age-related chronic and acute brain diseases. Here, we aimed investigate roles mechanisms CCL12, a circulating factor that is highly expressed plasma aged rodents after intracerebral hemorrhage (ICH) using parabiosis ICH models. Neurological deficit score (NDS), mortality rate, water content (BWC), levels inflammatory were determined assess degree ICH-induced injury. Peripheral cell infiltration...
Background: Intracerebral hemorrhage (ICH) is a debilitating and fatal condition with continuously rising incidence globally, without effective treatment available. Zhilong Huoxue Tongyu (ZLHXTY) capsule traditional Chinese medicine that used for ICH in China. However, the evidence based mechanism not clear. Purpose: To study protective effects of ZLHXTY capsules against pathogenesis via targetting nuclear factor kappa β (NFкβ) canonical signalling pathway. Methods: C57BL/6 J mice models...
Abstract Aging has been shown to contribute both the declined biofunctions of aging brain and aggravation acute damage, former could be reversed by young plasma. These results suggest that plasma treatment may also reduce damage induced intracerebral hemorrhage (ICH). In present study, we first found administration significantly reduced mortality neurological deficit score in ICH rodents, which might due decreased water content, damaged neural cells, increased survival neurons around...