A5031092468- Traditional Chinese Medicine Analysis
- Kruppel-like factors research
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Metabolomics and Mass Spectrometry Studies
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Epigenetics and DNA Methylation
- Medicinal Plants and Bioactive Compounds
- Venomous Animal Envenomation and Studies
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Traditional Chinese Medicine Studies
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Mitochondrial Function and Pathology
- Cardiovascular Effects of Exercise
- Nanoparticle-Based Drug Delivery
- Chemotherapy-induced organ toxicity mitigation
- Graphene and Nanomaterials Applications
- Atherosclerosis and Cardiovascular Diseases
- Nanoplatforms for cancer theranostics
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
Southwest Medical University
2021-2025
Background: Intracerebral hemorrhage (ICH) is a debilitating and fatal condition with continuously rising incidence globally, without effective treatment available. Zhilong Huoxue Tongyu (ZLHXTY) capsule traditional Chinese medicine that used for ICH in China. However, the evidence based mechanism not clear. Purpose: To study protective effects of ZLHXTY capsules against pathogenesis via targetting nuclear factor kappa β (NFкβ) canonical signalling pathway. Methods: C57BL/6 J mice models...
Toad venom, a dried product of secretion from Bufo bufo gargarizans Cantor or melanostictus Schneider, has had the therapeutic effects hepatocellular carcinoma confirmed. Bufalin and cinobufagin were considered as two most representative antitumor active components in toad venom. However, underlying mechanisms this effect have not been fully implemented, especially changes endogenous small molecules after treatment. Therefore, study was designed to explore intrinsic mechanism on cotreatment...
ContextCardiomyocyte hypertrophy due to hemodynamic overload eventually leads heart failure. Hirudin has been widely used in the treatment of cardiovascular diseases and NLRP3 inflammasome was proven induce cardiomyocyte pyroptosis. However, mechanism by which it inhibits remains unclear.ObjectiveTo explore hirudin inhibiting based on activation mitophagy.Materials & methods1 μM AngII for cardiac modeling H9C2 cells, cell viability quantified CCK-8 assay screen appropriate action...
Stable angina pectoris (SAP) is one of the main types coronary heart disease (CHD). To improve treatment outcomes, more effective biomarkers are needed. Currently, studies on metabolic characteristics SAP lacking. Here, we explored serum metabolomic profile and identified potential related pathways to assist clinical diagnosis SAP.Thirty patients with 30 healthy controls (CON) without stenosis were selected for this study. All underwent angiography. The metabolites two groups' samples...
The purpose of this study is to explore the mechanism Zhilong Huoxue Tongyu (ZL) capsule in treatment intracerebral hemorrhage (ICH) via targeting ferroptosis based on network pharmacology.The active ingredients and related key targets ZL were screened using Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform (TCMSP). gene ontology (GO) enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) also performed. Finally, identified validated an in-vivo model ICH.A...
Jiawei Xinglou Chengqi Granule (JXCG) is an effective herbal medicine for the treatment of ischemic stroke (IS). JXCG has been shown to effectively ameliorate cerebral symptoms in clinical practice, but underlying mechanisms are unclear. In this study, we investigated action IS by combining metabolomics with network pharmacology. The chemical composition was analyzed using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS). Ultra-high...
Zhilong Huoxue Tongyu (ZL) capsule is a classical traditional Chinese medicine (TCM) with satisfactory curative effects. Endothelial cell (EC) dysfunction plays an important role during myocardial fibrosis (MF). But the therapeutic effect of ZL on EC remains unknown in development MF. This study aims to investigate MF