A5100442394- Connexins and lens biology
- Inflammasome and immune disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Corneal surgery and disorders
- Heat shock proteins research
- Intraocular Surgery and Lenses
- Corneal Surgery and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Biochemical effects in animals
- Advanced Glycation End Products research
- Facial Rejuvenation and Surgery Techniques
- Biomarkers in Disease Mechanisms
- Glaucoma and retinal disorders
- Dermatologic Treatments and Research
- Ophthalmology and Visual Impairment Studies
- Pain Mechanisms and Treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
Ningxia Medical University General Hospital
2023-2025
Ningxia Medical University
2023-2025
Southwest Medical University
2023-2025
Jiangxi Agricultural University
2020-2024
State Grid Corporation of China (China)
2023-2024
Weatherford College
2024
North Carolina Central University
2023
Shenzhen Bay Laboratory
2023
Yantai University
2022
Shell (United States)
2022
Abstract The fall armyworm (FAW), Spodoptera frugiperda , is a destructive pest native to America and has recently become an invasive insect in China. Because of its rapid spread great risks China, understanding FAW genetic background pesticide resistance urgent essential develop effective management strategies. Here, we assembled chromosome-level genome male (SFynMstLFR) compared re-sequencing results the populations from America, Africa, Strain identification 163 individuals collected...
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an event. However, in-depth mechanistic understanding of their connection remains limited. This study aims to comprehensively analyze gene expression patterns pyroptosis-related differentially expressed genes (PRDEGs) employing integrated IS datasets machine learning techniques. primary objective was develop classification models identify crucial PRDEGs...
Aberrantly activated mammalian target of rapamycin complex 1 (mTORC1) plays a vital role in tumor angiogenesis, but its precise mechanisms are still unclear.
To identify proteomic differences between age-related nuclear cataracts (ARNCs) and normal lens nuclei.Total solubilized proteins from ARNC nuclei with different grades were compared controls by 2-D differential in-gel electrophoresis (2-D DIGE). Proteins abundances identified matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Sodium dodecyl sulfate polyacrylamide gel (SDS-PAGE) liquid chromatography tandem spectrometry (LC-MS/MS) analyses determined the...
Senescence is a leading cause of age-related cataract (ARC).The current study indicated that the senescenceassociated protein, p53, total laminin (LM), LMα4, and transforming growth factor-beta1 (TGF-β1) in cataractous anterior lens capsules (ALCs) increase with grades ARC.In ALCs, patient age, LM, TGF-β1, were all positively correlated p53.In epithelial cell (HLE B-3) senescence models, matrix metalloproteinase-9 (MMP-9) alleviated by decreasing expression LM LMα4; TGF-β1 induced increasing...
Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase (CHST6) gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS precipitate keratocytes stroma. We investigated roles for inflammatory responses MCD pathogenesis by examining lysosomal-autophagy pathway activation of pyroptosis keratocytes. Normal lesioned were obtained from patients undergoing transplantation. The subjected sequencing, RT-PCR, western blotting, transmission...
Thiel-Behnke corneal dystrophy (TBCD) is an epithelial-stromal TGFBI caused by mutations in the (transforming growth factor beta induced) gene, though underlying mechanisms and pathogenesis of TBCD are still obscure. The study identifies a novel mutation gene (p.Gly623_His626del) pedigree. Characteristics typical vacuole formation, irregular epithelial thickening thinning, deposition eosinophilic substances beneath epithelium, involvement anterior stroma were observed this pedigree via...
The prevalence of blind individuals in the north China is unknown. study aimed to investigate and causes blindness low vision rural areas Heilongjiang province 2008-2009. Cross-sectional study. A cluster random sampling method was used recruit participants all ages Heilongjiang. Trained professionals performed interviews clinical examinations measure visual acuity. relationships between or age, gender education level were analysed. main outcome rates bilateral vision. Of 11 787 subjects, 10...
To identify differential changes in proteins and metabolites underlying "fast" type 1 (T1DC) "slow" 2 (T2DC) diabetic cataract (DC) formation rat.Rat models of types diabetes consisted streptozotocin injection without with high-fat diet, respectively. Cataract progression was examined weekly. At week 6, total protein were comparatively quantitatively assessed by two-dimensional in-gel electrophoresis (2-D DIGE) coupled mass spectrometry, relevant metabolic examined. Differences high...
Abstract Uveitis is a devastating ocular disease that causes blindness. Our previous studies have achieved great advancements in depicting the genetic profiles of uveitis regarding complement pathway genes. This study aimed to provide additional insights into this interest by testing “central” factor system, C3 gene variants, two entities. Eight haplotype-tagging SNPs were genotyped 141 anterior (AU), 158 non-infectious intermediate and posterior (NIPU) 293 controls. The results showed none...