A5009734619- Flame retardant materials and properties
- Liver Disease Diagnosis and Treatment
- Neurobiology and Insect Physiology Research
- Ziziphus Jujuba Studies and Applications
- Olfactory and Sensory Function Studies
- Gut microbiota and health
- Natural Fiber Reinforced Composites
- Insect and Arachnid Ecology and Behavior
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Insect Resistance and Genetics
- Receptor Mechanisms and Signaling
- Ginger and Zingiberaceae research
- Polymer composites and self-healing
- Natural Products and Biological Research
- Diet, Metabolism, and Disease
- Neurological Disease Mechanisms and Treatments
- Polymer Nanocomposites and Properties
- Insect Utilization and Effects
- Traditional Chinese Medicine Analysis
- Medicinal Plant Pharmacodynamics Research
- Wood and Agarwood Research
- Biological and pharmacological studies of plants
- Cancer-related Molecular Pathways
- Drug Solubulity and Delivery Systems
Southwest Medical University
2019-2024
Northeast Forestry University
2024
Zhejiang Chinese Medical University
2021-2024
Chengdu University of Traditional Chinese Medicine
2019-2020
University of Copenhagen
2013-2015
The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes ccha1 are produced endocrine cells in midgut neurons brain of Drosophila melanogaster. Here, we used CRISPR/Cas9 technique to disrupt -2 identify mutant phenotypes with a focus on ccha-2 mutants. We found that both larval adult ccha2 mutants showed significantly reduced food intake as measured flies Capillary Feeding (CAFE) assay (up 72% compared wild-type). Locomotion tests had locomotor activity especially around 8 a.m....
The chemical composition of many essential oils indicates that they have sedative and hypnotic effects, but there is still a lack systematic studies on the effects oils. In addition, aromatherapy does not seem to side traditional psychotropic substances, which clearly worthwhile for further clinical scientific research. application in has received increasing attention, detailed pharmacological activities inhaled are increasingly needed.As insomniacs usually accompanied by symptoms depression...
Current evidence indicates a rising global prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), which is closely associated to conditions such as obesity, dyslipidemia, insulin resistance, and metabolic syndrome. The relationship between the gut microbiome metabolites in NAFLD gaining attention understanding pathogenesis progression dysregulated lipid metabolism inflammation. Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed clinical practice for alleviating hyperlipidemia symptoms...
The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably occur in all arthropods. Here, we used immunocytochemistry, situ hybridization, quantitative PCR (qPCR), to localize the two fruitfly Drosophila melanogaster. We found were localized endocrine cells of midgut larvae adult flies. These had appearance sensory cells, projecting processes close or into gut lumen. In addition, CCHamide-2 was also about forty neurons brain hemispheres ventral nerve cord...
The Aquilaria sinensis (Lour.) Gilg (CX)– Aucklandia costus Falc. (MX) herbal pair is frequently used in traditional Chinese medicine prescriptions for treating depression. volatile oil from CX and MX has been shown to have good pharmacological activities on the central nervous system, but its curative effect mechanism treatment of depression are unclear. Therefore, antidepressant CX–MX (CMVO) was studied chronic unpredictable mild stress (CUMS) rats. suppressive effects CMVO (25, 50, 100...
In this work, an environmentally friendly multicomponent flame retardant denoted as a sandwich-like 2D/2D montmorillonite/Zn2+-MEL-PA (MMT/ZnMPA) plate was successfully synthesized through "bottom-up" supramolecular self-assembly method, in which the ultrathin ZnMPA nanosheets were lying parallell on both sides of MMT plates. Then, MMT/ZnMPA served excellent performance nanofiller wood flour/polypropylene (WF/PP) composites. Microstructure characterization indicated that had uniform...
The active component-target network and protein-protein interaction of Compound Anshen essential oil were constructed. target functions related pathways analyzed to explore the mechanism in treatment insomnia. GC-MS was used detect chemical composition oil, TCMSP, STITCH, TTD, DrugBank databases searched predict screen targets Cytoscape software construct diagrams component-action networks, ClueGO analyze GO enrichment KEGG pathway target, systemsDock website database for molecular docking....
Abstract Volatile oil from traditional Chinese medicine has various biological activities and pharmacological in the central nervous system, digestive cardiovascular respiratory etc. These oils are widely used clinical practice. However, development of their applications is restricted due to disadvantages volatile oils, such as high stimulation, volatility poor stability. To improve stability a preparation process, its volatilization stable release must be controlled. In this paper, porous...
Zhilong Huoxue Tongyu capsule (ZHTC) is an effective traditional Chinese medicine compound for the treatment of ischemic stroke, which widely used in clinical stroke patients. However, it uncertain whether ZHTC affects through gut microbiota and serum metabolites. In this study, a rat model middle cerebral artery occlusion (MCAO) was prepared. By evaluating motor nerve function score, infarct size, brain tissue damage intestinal barrier damage, found that improved stroke-related symptoms...
Phellinus igniarius is a rare and precious medicinal fungus, displaying an outstanding physiological effect, especially the immunomodulatory effects. Previous studies indicated that water-soluble crude polysaccharide (MPFP) was obtained from mulberry leaf fermented with igniarius. In vitro cell assay revealed MPFP showed higher activity than of leaves (MP) mycelial (PP). Therefore, in this study, structure were measured, novel named MPFP2-1 separated through DEAE-52 cellulose column...
A high performance surface for balsa wood (BW) and delignified (DW) was created using a two-step synergistic strategy of impregnation layer by coating polyamide acid (PAA). The results showed that the PAA synthesized from 3,3,4,4-biphenyltetracarboxylic dianhydride (S-BPDA) 4,4'-diaminodiphenyl ether (ODA) optimal choice due to its exceptional comprehensive performance. Compared BW, bending strength coated BW (PBW) DW (PDW) significantly increased 193.1% 94.2%, respectively. Meanwhile,...
Ethnopharmacological relevance Non-alcoholic steatohepatitis (NASH) is a universal liver disorder, characterized by the development of hepatic fibrosis, ultimately leading to hepatocellular carcinoma. Endothelial dysfunction and endothelial-to-mesenchymal transition (EndMT) are crucial pathological processes in NASH progression fibrosis. Heshuxiaoji (HSXJ) pill, traditional Chinese medicine formula, has demonstrated significant clinical efficacy alleviating but its underlying mechanism...
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Background Modern research has proved that the volatile oil (VO) of Citrus × aurantium L. [Rutaceae] effect treating depression, but mechanism depression by sniffing not been studied. Purpose To study VO on depression. Methods Part I: Except for blank group, group and nasal drip were continuously administered 7 days to investigate optimal administration method. II: model, positive high, medium, low dose established chronic unpredictable stress test. The was given 7th day modeling 17...
Zhilong Huoxue Tongyu (ZL) capsule is a classical traditional Chinese medicine (TCM) with satisfactory curative effects. Endothelial cell (EC) dysfunction plays an important role during myocardial fibrosis (MF). But the therapeutic effect of ZL on EC remains unknown in development MF. This study aims to investigate MF