A5088116572- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Lipid metabolism and disorders
- Toxic Organic Pollutants Impact
- Retinoids in leukemia and cellular processes
- Effects and risks of endocrine disrupting chemicals
- Diet, Metabolism, and Disease
- Air Quality and Health Impacts
- Adipokines, Inflammation, and Metabolic Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Pesticide Exposure and Toxicity
- Peroxisome Proliferator-Activated Receptors
- Inflammasome and immune disorders
- Drug Transport and Resistance Mechanisms
- Atmospheric and Environmental Gas Dynamics
- Atmospheric chemistry and aerosols
- Glutathione Transferases and Polymorphisms
- Growth Hormone and Insulin-like Growth Factors
- Regulation of Appetite and Obesity
- Sphingolipid Metabolism and Signaling
Zhejiang Chinese Medical University
2019-2024
Hebei Agricultural University
2021
Current evidence indicates a rising global prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), which is closely associated to conditions such as obesity, dyslipidemia, insulin resistance, and metabolic syndrome. The relationship between the gut microbiome metabolites in NAFLD gaining attention understanding pathogenesis progression dysregulated lipid metabolism inflammation. Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed clinical practice for alleviating hyperlipidemia symptoms...
Rescuing endothelial cells from pyroptotic cell death emerges as a potential therapeutic strategy to combat diabetic atherosclerosis. Salvianolic acid A (SAA) is major water-soluble phenolic in the Salvia miltiorrhiza Bunge, which has been used traditional Chinese medicine (TCM) and health food products for long time. This study investigated whether SAA-regulated pyruvate kinase M2 (PKM2) functions protect cells. In streptozotocin (STZ)-induced ApoE −/− mice subjected Western diet, SAA...
Obesity-related metabolic diseases are associated with a chronic inflammatory state. Calenduloside E (CE) is triterpene saponin from sugar beet. In mouse models, CE reduced pro-inflammatory cytokines in white adipose tissue (WAT) and decreased macrophage infiltration of WAT. And inhibited pyroptosis J774A.1 cells WAT by inhibiting the activation nucleotide-binding oligomerization domain, leucine-rich repeat pyrin domain-containing 3 (NLRP3) inflammasome. Moreover, could trigger Sirtuin 2...
This study aims to investigate the role of Toll-like receptors (TLRs) on fine particulate matter (PM 2.5 )-induced inflammatory responses vascular endothelial cells. Inflammatory factors and TLRs were examined in aorta mice after nonsurgical intratracheal instillation PM as well human umbilical vein cells (HUVECs) treated with . In addition, effects TLR2 TLR4 inhibitors secretion interleukin 6 (IL-6) IL-1β expression determined HUVECs. The results showed that could increase IL-1β, IL-6,...
Carpesium abrotanoides L. (CA) is widely used as a medicinal plant in Asia. The biological activities of the extract from roots (PCA) and its major components were analyzed this study. PCA was separated identified with mass spectrometry. Furthermore, we sought to elucidate anticancer activity mechanisms. exerted anti-breast cancer through inhibiting expression glycolysis-related genes, such glucose transporter 1, lactate dehydrogenase A, hexokinase 2. Moreover, downregulated pyruvate kinase...
Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid aromatic rings, abundantly found in
Convergent evidence links traditional brominated flame retardants (BFRs) exposure to weight gain, while the obesogenic potency of new BFRs (NBFRs) remain largely unknown. Aiding by luciferase-reporter gene assay, present study revealed only pentabromoethylbenzene (PBEB), an alternative for penta-BDEs, binds with retinoid X receptor α (RXRα) but not peroxisomeproliferator γ (PPARγ) among seven testing NBFRs. An apparent induction adipogenesis in 3T3-L1 cells was observed at nanomolar PBEB,...
Epidemiological evidence links exposure to 2-ethylhexyl diphenyl phosphate (EHDPP) with lipid metabolic disruption, typically attributed nuclear receptors, while the role of membrane receptors remains underexplored. This study explored adiponectin receptor 1 (AdipoR1) in EHDPP-induced disturbances. We examined EHDPP's binding affinity and transcriptional impact on AdipoR1. AdipoR1 knockdown (AdipoR1
Environmental chemical exposures have been associated with metabolic outcomes, and typically, their binding to nuclear hormone receptors is considered the molecular initiating event (MIE) for a number of outcomes. However, more studies are needed understand influence such on cell membrane-bound adiponectin (AdipoRs), which critical regulators.
Peroxisome proliferator-activated receptor alpha (PPARα) and carnitine palmitoyltransferase 1 (CPT1) are important targets of lipid metabolism regulation for nonalcoholic fatty liver disease (NAFLD) therapy. In the present study, a set novel indole ethylamine derivatives (4, 5, 8, 9) were designed synthesized. The target product (compound can effectively activate PPARα CPT1a. Consistently, in vitro assays demonstrated its impact on accumulation oleic acid (OA)-induced AML12 cells. Compared...
The frequent detection of (2,3-dibromopropyl) phosphate (TDBPP) in environment has led to a consistent risk organisms. However, little is known about the toxicity TDBPP exclusive for its carcinogen. Mitochondrion that tightly relates adverse outcomes once deteriorated referred as target environmental pollutants. Here, we investigated role mitochondrial abnormality development cellular pathobiology especially lipid deposition when response mitochondria-rich hepatocyte (AML12) at same order...