A5116016368- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Cancer-related gene regulation
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Molecular Biology Techniques and Applications
- Immune cells in cancer
- Forensic and Genetic Research
- Genomics and Phylogenetic Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Chronic Kidney Disease and Diabetes
- Asthma and respiratory diseases
- HIV Research and Treatment
- DNA Repair Mechanisms
China Medical University
2012-2025
Wenzhou Medical University
2010-2025
Chinese PLA General Hospital
2015-2025
Nantong University
2012-2025
Beijing University of Chemical Technology
2010-2025
Northwestern Polytechnical University
2014-2025
Shaanxi Provincial People's Hospital
2025
Shanxi Medical University
2016-2025
The First Hospital of Changsha
2025
Wuhan University
2011-2025
Acupuncture, an ancient therapeutic technique, is emerging as important modality of complementary medicine in the United States.The use and efficacy acupuncture treatment are not yet widely accepted Western scientific medical communities.Demonstration regionally specific, quantifiable effects on relevant structures human brain would facilitate acceptance integration this into practice modern medicine.Research with animal models indicates that many beneficial may be mediated at subcortical...
We have sequenced the genome of a second Drosophila species, pseudoobscura , and compared this to sequence melanogaster primary model organism. Throughout evolution vast majority genes remained on same chromosome arm, but within each arm gene order has been extensively reshuffled, leading minimum 921 syntenic blocks shared between species. A repetitive is found in D. at many junctions adjacent blocks. Analysis novel element family suggests that recombination offset elements may given rise...
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and fourth lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little mutational processes responsible. To identify genome-wide signatures, performed either whole-genome sequencing (WGS) or whole-exome (WES) on 104 ESCC individuals combined our data those 88 previously reported samples. An APOBEC-mediated signature 47% 192 tumors suggests...
HOTAIR, a long intervening non-coding RNA (lincRNA), associates with the Polycomb Repressive Complex 2 (PRC2) and is reported to reprogram chromatin organization promote tumor progression. However, little known about roles of this gene in development chemoresistance phenotype lung adenocarcinoma (LAD). Thus, we investigated involvement HOTAIR resistance LAD cells cisplatin. In study, show that expression was significantly upregulated cisplatin-resistant A549/DDP compared parental A549 cells....
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease difficult to diagnose, treat control. We present a draft genomic sequence worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with genome sequences from other taxa show that granulosus has acquired spectrum of genes, including EgAgB family, whose products are secreted parasite interact redirect host immune responses....
The past 30 years have witnessed significant increases in the prevalence of type 2 diabetes mellitus (T2DM) China. A 1980 epidemiological survey that included 000 people from 14 provinces and cities nationwide indicated was 0.67% 1. 1994–1995 210 19 found 2.5% among individuals who were 25–64 old (with a population standardized rate 2.2%) impaired glucose tolerance 3.2% 2.1%) 2. national nutrition conducted 2002, showed prevalences 4.5% 1.8% over 18 urban rural areas, respectively 3. In...
In vitro fertilization involving frozen embryo transfer and donor oocytes increases preeclampsia risk. These in protocols typically yield pregnancies without a corpus luteum (CL), which secretes vasoactive hormones. We investigated whether CL disrupt maternal circulatory adaptations increase Women with 0 (n=26), 1 (n=23), or >1 (n=22) were serially evaluated before, during, after pregnancy. Because increasing arterial compliance is major physiological adaptation pregnancy, we assessed...
Though an acute kidney injury (AKI) episode is associated with increased risk of chronic disease (CKD), the mechanisms determining transition from to irreversible are not well understood. To extend our understanding renal repair, and its limits, we performed a detailed molecular characterization murine ischemia/reperfusion (IRI) model for 12 months after injury. Together, data comprising RNA-sequencing (RNA-seq) analysis at multiple time points, histological studies, cellular targeted gene...
Atherosclerosis is an inflammatory process due to oxidized low-density lipoprotein (oxLDL) accumulation in macrophages. We investigated the involvement of microRNAs oxLDL and response The expression miR-146a decreases under stimulation. MiR-146a significantly reduces intracellular LDL cholesterol content secretion interleukin 6, 8, chemokine (C-C motif) ligand 2 matrix metallopeptidase 9. Toll-like receptor 4 (TLR4) a relevant target miR-146a, inhibits activation TLR4-dependent signaling...
The CRISPR/Cas9 gene editing technology holds promise for the treatment of multiple diseases. However, inability to perform specific in targeted tissues and cells, which may cause off-target effects, is one critical bottlenecks therapeutic application CRISPR/Cas9. Herein, macrophage-specific promoter-driven Cas9 expression plasmids (pM458 pM330) were constructed encapsulated cationic lipid-assisted PEG-b-PLGA nanoparticles (CLAN). obtained encapsulating able specifically express macrophages...
Long noncoding RNAs (lncRNAs) have been identified as oncogenes or tumor suppressors that are involved in tumorigenesis and chemotherapy drug resistance. Maternally expressed gene 3 (MEG3) is an imprinted located at 14q32 encodes lncRNA, decreased MEG3 expression plays important role multiple cancers. However, its biological the development of chemoresistance phenotype human lung adenocarcinoma (LAD) unknown. This study aimed to observe LAD evaluate clinical significance resistance cells...
Dysregulated expression of long noncoding RNAs has been reported in many types cancers, indicating that it may play a critical role tumorigenesis. The RNA highly up‐regulated liver cancer (HULC) was first characterized hepatocellular carcinoma. However, the detailed mechanisms HULC remain unclear. Here, we demonstrate novel mechanism by which plays oncogenic roles through modulating phosphorylation status its interaction protein. First, validated markedly increased levels carcinoma tissues...
The NLRP3 inflammasome is a well-studied target for the treatment of multiple inflammatory diseases, but how to promote current therapeutics remains large challenge. CRISPR/Cas9, as gene editing tool, allows direct ablation at genomic level. In this study, we screen an optimized cationic lipid-assisted nanoparticle (CLAN) deliver Cas9 mRNA (mCas9) and guide RNA (gRNA) into macrophages. By using CLAN encapsulating mCas9 gRNA-targeting (gNLRP3) (CLANmCas9/gNLRP3), disrupt macrophages,...
Abstract Background Remimazolam besylate is a newer benzodiazepine with characteristics of quick onset effects, short maintenance and recovery times without accumulation in tissues. This trial was conducted to confirm the efficacy safety remimazolam versus propofol during hysteroscopy. Methods Patients undergoing hysteroscopy were randomly assigned either (Group R) or group P). Group R administered an induction dose 0.2 mg/kg dosage 1.0 mg/kg/h. In P, started at 1.5–2.0 then maintained...