Abstract Background Remimazolam besylate is a newer benzodiazepine with characteristics of quick onset effects, short maintenance and recovery times without accumulation in tissues. This trial was conducted to confirm the efficacy safety remimazolam versus propofol during hysteroscopy. Methods Patients undergoing hysteroscopy were randomly assigned either (Group R) or group P). Group R administered an induction dose 0.2 mg/kg dosage 1.0 mg/kg/h. In P, started at 1.5–2.0 then maintained...

Abstract Background Breast cancer (BC) is one of the most prevalent malignant tumours that threatens women health worldwide. It has been reported circular RNAs (circRNAs) play an important role in regulating tumour progression and microenvironment (TME) remodelling. Methods Differentially expression characteristics immune correlations circRNAs BC were verified using high‐throughput sequencing bioinformatic analysis. Exosomes characterised by nanoparticle transmission electron microscopy...

The build-up of senescent cells in tissues is a key indicator aging, associated with negative prognosis and therapy resistance. Despite immune dysfunction related to also known as immunosenescence, recognized factor this process, the exact mechanisms are still unclear. In study, we reported that melatonin deficiency accelerated macrophage senescence triple-negative breast cancer (TNBC), whereas, could defend macrophages against through Nfatc1-Trim26-cgas-Sting pathway. Mechanistically,...

Using visual bibliometric analysis, the application and development of artificial intelligence in clinical esophageal cancer are summarized, research progress, hotspots, emerging trends elucidated.On April 7th, 2022, articles reviews regarding AI cancer, published between 2000 2022 were chosen from Web Science Core Collection. To conduct co-authorship, co-citation, co-occurrence analysis countries, institutions, authors, references, keywords this field, VOSviewer (version 1.6.18), CiteSpace...

Triple-negative breast cancer (TNBC), a heterogeneous subtype of (BC), had poor prognosis. Endoplasmic reticulum (ER) stress was responsible for cellular processes and played crucial role in the cell function. ER is complex dynamic process that can induce abnormal apoptosis death. However, underlying mechanism involved TNBC not well defined.We identified ubiquitin-specific protease 19 (USP19) as negative regulator further investigation. The effects USP19 on BC proliferation were assessed...

Currently, flow cytometry and immunomagnetic bead purification are the most commonly used cell sorting methods. We performed this study because there few reports that directly compare efficiency influence on functions of these two The in vitro cultured third-generation bone marrow mesenchymal cells from newborn Sprague-Dawley rats were sorted purified using sterile beads to obtain CXCR4-positive stem (CXCR4+-MSCs). yield purity (detected by cytometry), viability MTT method), chemotactic...

To investigate the reparative efficacy of tissue-engineered osteochondral (TEO) graft for repairing defect in goat, we designed a double-chamber stirring bioreactor to construct bone and cartilage composites simultaneously one β -TCP scaffold observed effect vivo. The defects were created goats all animals divided into 3 groups randomly. In A, was treated with TEO which cultured mechanical stimulation stir; group B, without C, TEO. At 12 weeks 24 after operation, effects different assessed...

Breast cancer (BRCA) has become the highest incidence of due to its heterogeneity. To predict prognosis BRCA patients, sensitive biomarkers deserve intensive investigation. Herein, we explored role N 6 -methyladenosine-related long non-coding RNAs (m A-related lncRNAs) as prognostic in patients acquired from The Cancer Genome Atlas (TCGA; n = 1,089) dataset and RNA sequencing (RNA-seq) data ( 196). Pearson’s correlation analysis, univariate multivariate Cox regression were performed select m...

Abstract Background Improved understanding of the stemness regulation mechanism in intrahepatic cholangiocarcinoma (ICC) could identify targets and guidance for adjuvant transarterial chemoembolization (TACE). Methods TCGA database was excavated to ICC stemness-associated genes. The pro-stemness effect target genes further analyzed by sphere formation assay, qRT-PCR, western blot, flow cytometric analysis, IHC, CCK8 assay metabolomic analysis. Based on multivariate a nomogram patients with...

Although the operation time of hysteroscopy is short, incidence postoperative nausea and vomiting high. The aim this study was to compare in when remimazolam combined with remifentanil or alfentanil.

<p>Human osteosarcoma is the most prevalent primary malignant bone tumor with high frequency of invasion and metastasis. Strong resistance coupled toxicity currently available chemotherapeutic drugs poses challenge in treatment. The study aimed to investigate if fisetin, a dietary flavonoid induced apoptosis human (U-2 OS) cells. Fisetin at 20-100 µM effectively reduced viability OS cells, by significantly inducing expression caspases (Caspases- 3,-8 -9) pro-apoptotic proteins (Bax...

A drying device based on infrared radiation heating technology combined with temperature and humidity process control was created to increase the effectiveness quality of sea buckthorn. Based conventional k-turbulence model, velocity field in air distribution chamber simulated using COMSOL 6.0 software. The airflow medium investigated, accuracy model verified. Given that inlet each layer original had a different velocity, flow improved by including semi-cylindrical spoiler. results showed...

The five major RNA methylation modifications (m6A, m1A, m6Am, m5C, and m7G) exert biological roles in tumorigenicity immune response, mediated mainly by "writer" enzymes. Here, the prognostic values of enzymes TCP1 role drug resistance breast cancer (BC) were explored for further therapeutic strategies.We comprehensively characterized clinical, molecular, genetic features subtypes consensus clustering. modification "Writers" related genes_risk (RMW_risk) model BC was constructed via a...

This study investigated the effects of hot air drying (HAD), infrared-assisted (IR-HAD), vacuum freeze (VFD), and pulsed-vacuum (PVD) on characteristics, color, microstructure, total phenolic content (TPC), flavonoid (TFC), vitamin C (Vc) content, odor analysis using electronic nose sea buckthorn pomace. The results showed that IR-HAD exhibited highest rate shortest time (250 min). PVD TPC, TFC, Vc while maintaining a color difference ΔE value closest to fresh sample. microstructure no...

Abstract Background Although neoadjuvant chemotherapy (NAC) is currently the best therapy for triple‐negative breast cancer (TNBC), resistance still occurs in a considerable proportion, thus it crucial to understand mechanisms and identify predictive biomarkers patients selection. Methods Biopsy samples were collected from 21 with TNBC who underwent NAC. Whole‐exome sequencing (WES), targeted sequencing, multiplex immunohistochemistry (mIHC) carried out on clinical used validate potential...

Abstract Background: Triple-negative breast cancer (TNBC) is a type of highly invasive with poor prognosis. According to new research, long noncoding RNAs (lncRNAs) play significant role in the progression cancer. Although lncRNAs has been well reported, few studies have focused on TNBC. This study aimed explore biological function and clinical significance forkhead box C1 promoter upstream transcript (FOXCUT) triple-negative Methods: Based bioinformatic analysis genome atlas (TCGA)...

Abstract Background: Remimazolam besylate is a new type of benzodiazepine that has the characteristics quick effects, short maintenance and recovery times, no accumulation. Compound opioids can have sedative effect in some endoscopic examinations. This trial was conducted to confirm efficacy safety remimazolam versus propofol during hysteroscopy. Methods: Patients undergoing hysteroscopy were randomly assigned either (Group R, n=41) or group P, n=41). Group R administered an induction dosage...

Background Breast cancer is becoming a tumor with the highest morbidity rate, and inflammation-induced cell death namely pyroptosis reportedly plays dual roles in cancers. However, specific mechanism between clinical prognosis of breast patients indistinct. Hence, novel pyroptosis-related biomarkers their contributing factors deserve further exploration to predict cancer. Methods Pearson’s correlation analysis, univariate multivariate Cox regression analysis were utilized obtain six optimal...