A5004664981- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Aortic Disease and Treatment Approaches
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Ear and Head Tumors
- Pharmacogenetics and Drug Metabolism
- Metal and Thin Film Mechanics
- Bone health and treatments
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Inflammatory mediators and NSAID effects
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Trauma Management and Diagnosis
- Cardiac and Coronary Surgery Techniques
- interferon and immune responses
- Fibroblast Growth Factor Research
- Atrial Fibrillation Management and Outcomes
- Neurofibromatosis and Schwannoma Cases
- Cancer Mechanisms and Therapy
Nanchang University
2012-2024
Second Affiliated Hospital of Nanchang University
2012-2024
Tongji Hospital
2000
CD8+ T cells play a critical role in the innate antitumour immune response. Recently, cell dysfunction has been verified various malignant cancers, including non-small lung cancer (NSCLC). However, molecular biological mechanisms of human NSCLC are still unclear.The expression circular ubiquitin-specific protease-7 (circUSP7) tissues, exosomes, and lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Exosomes were isolated from culture medium plasma patients...
Abstract Background Previous studies have confirmed the oncogenic role of HMGB2 in various cancers, but biological functions HMGB2-derived circRNAs remain unknown. Thus, we intended to investigate potential lung adenocarcinomas (LUAD) and squamous cell carcinomas (LUSC). Methods The expression profiles LUAD LUSC tissues matched normal were assessed using qRT–PCR. circHMGB2 progression was determined vitro by Transwell, CCK-8, flow cytometry immunohistochemistry assays, as well vivo an...
The dysregulation of circular RNA (circRNA) expression is involved in the progression several cancers, including non-small cell lung cancer (NSCLC). However, role and underlying molecular mechanisms circRNA FGFR3 (circFGFR3) NSCLC remains unknown. Here, we used quantitative real-time polymerase chain reaction to validate that circFGFR3 was higher tissues than paratumor tissues. Furthermore, our study indicated forced promoted invasion proliferation. Mechanistically, found proliferation via...
Emerging evidences has demonstrated that dysregulation of long non-coding RNAs (lncRNAs) is critically involved in esophageal squamous cell carcinoma (ESCC) progression. However, the function lncRNA PSMA3-AS1 ESCC unclear. Therefore, we aimed to explore functions and potential mechanisms cells progression.Here, found expression was significantly up-regulated tissues. Forced correlated with tumor size, distant metastasis, poor prognosis patients. Functionally, PSMA3-AS1-overexpression...
// Yun-Fei Liao 1, 2, * , Yong-Bing Wu Xiang Long Shu-Qiang Zhu 2 Chun Jin 1 Jian-Jun Xu Jian-Yong Ding Department of Thoracic Surgery, The Affiliated Zhongshan Hospital Fudan University, Shanghai 200032, P. R. China Cardiothoracic Second Nanchang 330000, These authors contributed equally to this work Correspondence to: Ding, e-mail: dingjianyongmd@163.com Xu, jianjxu@126.com Keywords: non-small cell lung cancer, bromodomain containing protein 4, proliferation, invasion, apoptosis Received:...
In recent years, circular RNAs (circRNAs) have been increasingly reported to play a crucial role in the proliferation, migration, and invasion of non-small-cell lung cancer (NSCLC) cells. However, circRNA MET (circMET) oncogenic mechanism that drives NSCLC development progression remains largely unknown. this study, present results demonstrated circMET expression was significantly higher tissues than peritumoral using quantitative real-time polymerase chain reaction. Notably, patients with...
Aberrant expression of TRIM‐containing protein 44 (TRIM44) acts as a promoter in multiple cancers. Here, we investigated the biological functions and clinical significance TRIM44 human esophageal cancer (HEC). was significantly higher HEC tissues than corresponding normal at both mRNA (2.42 ± 0.52 vs 0.99 0.25) (1.01 0.27 0.30 0.13) levels. Patients with high showed poor differentiation ( P = 1.39 × 10 −5 ), advanced TNM stage 3.87 −4 ) and, most importantly, poorer prognosis 2.80 ). played...
Objectives: Ring finger protein 38 (RNF38), as an E3 ubiquitin ligase, plays essential role in multiple biological processes by controlling cell apoptosis, cycle and DNA repair, resides chromosome 9 (9p13) which is involvement cancer pathogenesis including lung cancer.However, its function tumorigenesis remains unclear.Hence, this study set out to investigate the clinical implications of RNF38 non-small (NSCLC).Materials Methods: Immunohistochemistry, quantitative real-time polymerase chain...
Abstract Background Lung cancer is one of the most lethal malignant tumors that endangers human health. adenocarcinoma (LUAD) has increased dramatically in recent decades, accounting for nearly 40% all lung cases. Increasing evidence points to importance competitive endogenous RNA (ceRNA) intrinsic mechanism various cancers. However, behavioral characteristics ceRNA network need further study. Methods Groups based on SLC2A1 expression were used this study identify associated networks and...
Fused in sarcoma/translocated liposarcoma (FUS/TLS), a ubiquitous and multifunctional DNA RNA-binding protein, contributes an important function cancer neurodegenerative disease; however, its role lung remains unclear. In the present study, expression of FUS/TLS non-small cell (NSCLC) significance for predicting clinical outcome patients with NSCLC, was examined. investigated NSCLC tissues their matched adjacent non-tumorous by reverse transcription-quantitative polymerase chain reaction,...
The role of TELO2-interacting protein 1 (TTI1) in the progression several types cancer has been reported recently. aim this study was to estimate expression and potential value TTI1 non-small-cell lung (NSCLC) patients. its prognostic NSCLC from Cancer Genome Atlas (TCGA) database Gene Expression Omnibus (GEO) were analyzed. To verify bioinformatics findings, a tissue microarray containing 160 paired peritumoral tissues patients analyzed by immunohistochemistry for TTI1. Subsequently, roles...
Individuals with implanted mechanical valve prostheses require lifelong anticoagulation therapy warfarin. The narrow therapeutic index of warfarin makes it difficult to dose and maintain proper anticoagulation. A number single nucleotide polymorphisms (SNPs) affecting vitamin K or metabolism have been shown affect dosing. Our aim was study the effect CYP4F2 rs2108622-1347 (C > T) variant on dosing in Chinese patients.We studied 352 patients after heart replacement surgery. Warfarin for...
There is an increasing demand for minimally invasive aortic valve replacement. This study aimed to investigate the safety and feasibility of replacement through a right parasternal second intercostal transverse incision. was retrospective study, we collected information from 111 patients who underwent isolated surgery performed by same surgeon January 2018 December 2019. According operative approach, were divided into sternotomy (SAVR) group (n = 62) (Mini-AVR) 49). We compared...
Objectives: An increase in the trimethylation of lysine 4 histone 3 (H3K4me3) has been reported to be involved development several types tumors.However, level and role H3K4me3 human esophageal cancer (HEC) remain unknown.Here, we assessed clinical significance HEC.Methods: The was determined 15 pairs HEC paracancerous tissues by Western blotting.A tissue microarray including samples from 100 patients analyzed immunohistochemistry determine relationship between clinicopathological features...
Minimally invasive cardiac surgical techniques are increasingly applied in the treatment and management of a variety adult ventricular septal defects (VSDs). However, repair subarterial VSDs via left anterior mini-thoracotomy is rarely reported. The present study aimed to determine feasibility safety for VSDs. Twenty-seven patients underwent mini-thoracotomy. approach includes two options skin incision access, longitudinal transverse incisions. length was 4.1–6.1 cm (mean, 5.1 ± 0.6 cm)....
There is an increasing demand for minimally invasive myxoma resection. This study aimed to investigate the safety and feasibility of resection.In this retrospective study, we collected information from 95 patients who underwent resection between January 2016 December 2020. Based on operative approach, were divided into (Mini-MR) group (N = 30) sternotomy (SMR) 65). Intraoperative postoperative data compared two groups.The ventilator-assisted time, CSICU hospital stay shorter in Mini-MR than...
Warfarin is the most recommended oral anticoagulant after artificial mechanical valve replacement therapy. However, narrow therapeutic window and varying safety efficacy in individuals make dose determination difficult. It may cause adverse events such as hemorrhage or thromboembolism. Therefore, advanced algorithms are urgently required for use of warfarin.To establish a warfarin model patients prosthetic southern China combination with clinical genetic variables, to improve accuracy ideal...
Background. The need for minimally invasive Bentall surgery the treatment of aortic lesions with insufficiency is increasing; however, comparative studies on safety procedure and sternotomy are lacking. Methods. Clinical data 56 patients who underwent performed by same surgical team at our center between December 2018 2021 were retrospectively analyzed followed up 6 months after discharge. After dividing into a right anterior chest (RAT-Bentall) group (n = 13) conventional (C-Bentall) 43),...
Background: Increasing knowledge has made it crucial to identify and minimize potential risk factors in order prevent non-small cell lung cancer (NSCLC). This initiative aims utilize Mendelian randomization analysis exposure that could be causally linked NSCLC. The results will help create new ways of controlling preventing Methods: GEO database's NSCLC data were used find differentially expressed genes, which further analyzed for GO KEGG pathway enrichment. Use enrichment as a guide screen...
Objective: To detect the expression of heparanase (HPSE) in oral squamous cell carcinoma (OSCC) with different metastatic potentials and investigate its clinical significance. Methods: Transcriptional translational status HPSE OSCC lines capacities, primary samples their paired cancer tissues were determined using real-time polymerase chain reaction (PCR) Western blotting analysis. Immunohistochemistry was used to evaluate 131 samples. The correlation between pattern clinicopathological...