A5101973930- Prostate Cancer Treatment and Research
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Metabolism, Diabetes, and Cancer
- Renal and related cancers
- Cancer, Hypoxia, and Metabolism
- Pediatric Urology and Nephrology Studies
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Biomedical Text Mining and Ontologies
- RNA and protein synthesis mechanisms
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Urological Disorders and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- COVID-19 Clinical Research Studies
- Hormonal and reproductive studies
- Ubiquitin and proteasome pathways
Zhongnan Hospital of Wuhan University
2021-2025
Wuhan University
2004-2025
Fudan University Shanghai Cancer Center
2017-2025
Shanghai Medical College of Fudan University
2017-2025
Hubei Cancer Hospital
2023-2024
China Medical University
2017-2024
Shandong Provincial Hospital
2024
Shandong First Medical University
2024
Shanghai Ninth People's Hospital
2024
Shanghai Jiao Tong University
2024
Abstract Objectives Drug repurposing, which finds new indications for existing drugs, has received great attention recently. The goal of our work is to assess the feasibility using electronic health records (EHRs) and automated informatics methods efficiently validate a recent drug repurposing association metformin with reduced cancer mortality. Methods By linking two large EHRs from Vanderbilt University Medical Center Mayo Clinic their tumor registries, we constructed cohort including 32...
// Haibing Xiao 1, 2 , Kun Tang Peijun Liu Ke Chen Junhui Hu Jin Zeng Wei 3 Gan Yu Weiming Yao Hui Zhou Heng Li Yingtian Pan 4 Anping 5 Zhangqun Ye Ji Wang 6 Hua Xu Qihong Huang 1 Department of Urology, Tongji Hospital, Medical College, Huazhong University Science and Technology, Wuhan 430030, China Institute Translational Medicine Center, Biomedical Engineering, Stony Brook University, Brook, New York 11794, USA The Wistar Institute, Philadelphia, Pennsylvania 19104, Cell Death Cancer...
PTENP1 is a pseudogene of the PTEN tumor suppression gene (TSG). The functions in clear-cell renal cell carcinoma (ccRCC) have not yet been studied. We found that downregulated ccRCC tissues and cells due to methylation. are direct targets miRNA miR21 their expression suppressed by lines. promotes proliferation, migration, invasion vitro, growth metastasis vivo. Overexpression expressing reduces invasion, growth, metastasis, recapitulating phenotypes induced expression. sensitizes these...
Summary Background Coronavirus disease 2019 (COVID-19) is a global pandemic but the follow-up data of discharged patients was barely described. Aim To investigate clinical outcomes, distribution quarantine locations and infection status contacts COVID-19 after discharge. Design A prospective cohort study. Methods Demographics, baseline characteristics 131 from 3 February 2020 to 21 in Wuhan, China were collected analyzed by reviewing medical records retrospectively. Post-hospitalization...
Abstract Metastasis is a critical event affecting breast cancer patient survival. To identify molecules contributing to the metastatic process, we analysed The Cancer Genome Atlas (TCGA) data and identified 41 genes whose expression inversely correlated with Here show that GABA A receptor alpha3 (Gabra3), normally exclusively expressed in adult brain, also cancer, high of Gabra3 being We demonstrate activates AKT pathway promote cell migration, invasion metastasis. Importantly, find an...
// Jinjin Lu 1 , Xiufen Zheng 2 Fan Li Yang Yu 3 Zhong Chen Liu Zhihua Wang Hua Xu Weimin Department of Urology, Tongji Hospital, Medical College, Huazhong University Science and Technology, Wuhan, 430030, P. R. China Pathology, Oncology, Surgery, Western University, Lawson Health Research Institute, London, Ontario, N6A 5A5, Canada Ultrasound, Correspondence to: Li, email: fanli117@hotmail.com Keywords: tunneling nanotubes, mitochondria, bladder cancer, cell invasion, connection Received:...
Abstract Background Gastric cancer is the second-leading cause of global deaths, with metastatic disease representing primary mortality. To identify candidate drivers involved in oncogenesis and tumor evolution, we conduct an extensive genome sequencing analysis progression a diffuse gastric cancer. This involves comparison between from hereditary syndrome proband its recurrence as ovarian metastasis. Results Both metastasis have common biallelic loss-of-function both CDH1 TP53 suppressors,...
Background Long noncoding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety biological functions. They aberrantly expressed many types cancers. In this study, we described lncRNAs profiles 6 pairs human renal clear cell carcinoma (RCCC) and the corresponding adjacent nontumorous tissues (NT) by microarray. Methodology/Principal Findings With abundant varied probes accounting 33,045 LncRNAs our microarray, number that at certain level could be detected is 17157....
Metastasis have considered as an important clinical obstacle in the treatment of human cancer including bladder cancer. Post-transcriptional regulation has emerged robust effectors metastasis. MiRNAs are involved development and progression, acting tumor suppressors or oncogenes. In this study, we focus on it that microRNA-34a functions anti-metastatic microRNA suppress angiogenesis by directly targeting CD44.The expression mir-34a was detected quantitative real-time PCR. Oligonucleotide...
To explore characteristics of urinary stone composition in China, and determine the effects gender, age, body mass index (BMI), location, geographical region on composition.We prospectively used Fourier-transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals seven areas between 1 June 2010 31 May 2015. Chi-squared tests logistic regression analyses were associations BMI, region.The most common constituents were:...
The study was aimed at investigating the characteristics of peripheral blood lymphocyte subsets and serum cytokines in children with 2019 novel coronavirus (2019-nCoV) pneumonia.Children 2019-nCoV pneumonia or respiratory syncytial virus (RSV) were included. Data including collected analyzed.56 patients included study, 40 16 RSV pneumonia. Compared pneumonia, had higher count CD3+8+ lymphocyte, percentages CD3+, lymphocytes a lower percentage CD19+ lymphocyte. IL-10 level significantly One...
Open intent classification is a challenging task in dialogue systems. On the one hand, it should ensure quality of known identification. other needs to detect open (unknown) without prior knowledge. Current models are limited finding appropriate decision boundary balance performances both intents and intent. In this paper, we propose post-processing method learn adaptive (ADB) for classification. We first utilize labeled samples pre-train model. Then, automatically spherical each class with...
Abstract Loss of function the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark clear cell renal carcinoma (ccRCC). The importance heterogeneity in loss this has been under reported. To study impact intratumoral VHL observed human ccRCC, we engineered deletion four RCC models, including new primary line derived from an aggressive metastatic case. gene-deleted (VHL-KO) cells underwent epithelial-to-mesenchymal transition (EMT) and exhibited increased motility but diminished...
Abstract Background Triple‐negative breast cancer (TNBC) is a highly heterogeneous and clinically aggressive disease. Accumulating evidence indicates that tertiary lymphoid structures (TLSs) tumor budding (TB) are significantly correlated with the outcomes of patients who have TNBC, but no integrated TLS‐TB profile has been established to predict their survival. The objective this study was investigate relationship between TLS/TB ratio clinical TNBC using artificial intelligence (AI)‐based...
The yeast retrotransposon Ty can be used to insert multiple copies of a gene at new sites in the genome. interest is inserted into GALI-Ty fusion construct; entire "amplification cassette" then introduced on high copy number plasmid vector. Transposition element carrying occurs Two genes, bacterial neomycin phosphotransferase and TRPl gene, were amplified this way. Although genes about 1 kilobase length, they same extent as 40-base pair segment. benefit "shotgun" approach that amplification...
Warfarin pharmacogenomic algorithms reduce dosing error, but perform poorly in non-European-Americans. Electronic health record (EHR) systems linked to biobanks may allow for analysis, they have not yet been used this purpose.We BioVU, the Vanderbilt EHR-linked DNA repository, identify European-Americans (n = 1022) and African-Americans 145) on stable warfarin therapy evaluated effect of 15 pharmacogenetic variants dose.Associations between VKORC1, CYP2C9 CYP4F2 with weekly dose were...