A5101711336- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Ureteral procedures and complications
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Monoclonal and Polyclonal Antibodies Research
- Reproductive Biology and Fertility
- Urinary and Genital Oncology Studies
- Galectins and Cancer Biology
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- Phytochemical and Pharmacological Studies
- Renal and related cancers
- Advanced Proteomics Techniques and Applications
- Paleopathology and ancient diseases
- Immunotherapy and Immune Responses
- RNA modifications and cancer
Hainan Medical University
2014-2024
Jiangxi Academy of Sciences
2024
Southern Medical University
2024
Hainan Medical College Hospital
2003-2023
Guangxi Medical University
2017
First Affiliated Hospital of GuangXi Medical University
2017
Central South University
2009
Xiangya Hospital Central South University
2009
To explore characteristics of urinary stone composition in China, and determine the effects gender, age, body mass index (BMI), location, geographical region on composition.We prospectively used Fourier-transform infrared spectroscopy to analyse stones from consecutive patients presenting with new-onset urolithiasis at 46 hospitals seven areas between 1 June 2010 31 May 2015. Chi-squared tests logistic regression analyses were associations BMI, region.The most common constituents were:...
Only B lymphocytes can express immunoglobulins according to the traditional immunological theories, and expression of immunoglobulin G (IgG) messenger RNA (mRNA) protein was found in certain human cancer cells recently. However, pattern IgG its possible role urothelial carcinoma are still elusive. In this study, we investigated two cell lines, T24 BIU-87, 56 cases clinical tissues. The mRNA positively detected by situ hybridization reverse transcription PCR; furthermore, also...
The etiology and pathogenesis of bladder cancer (BCa) is complex. MicroRNA (miRNA) has been implicated in BCa. Targeting signal transducer activator transcription 3 (STAT3) by miR‑124 to regulate tumorigenesis demonstrated other types cancer. In the present study, levels were downregulated BCa T24 cell line STAT3 was increased lines. Transfection mimics into cells significantly inhibited expression. A luciferase assay confirmed that directly targeted 3'untranslated region inhibit STAT...
According to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater 5 years; however, long-term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents China was initiated late, and related research is lacking. Analyze data understand current situation implement measures improve practices.
Abstract Bladder cancer is one of the most common malignant diseases in urinary system, with poor survival after metastasis. Activation-induced cytidine deaminase (AID), a versatile enzyme involved antibody diversification, an oncogenic gene that induces somatic hypermutation and class-switch recombination (CSR). However, contribution AID-mediated DNA demethylation to bladder urothelial cell carcinoma (BUCC) remains unclear. Herein, we evaluated impact on BUCC caused by AID explored network...
The outbreak of epidemics such as African swine fever has intensified the use disinfectants in pig farms, resulting an increasing residual concentration environmental media; however, high-frequency excessive that damage farm manure anaerobic fermentation systems and their mechanisms not attracted enough attention. Especially, complex effects on for remain poorly understood, thus impeding application practical systems. Herein, we explored glutaraldehyde disinfectant methane production,...
Although advances have been made in the development of antiangiogenesis targeted therapy and surgery, metastatic clear cell renal carcinoma (ccRCC) is still incurable. Activation-induced cytidine deaminase (AID) mainly expressed a variety germ somatic cells, induces hypermutation class-switch recombination, playing vital role antibody diversification. We confirmed that AID was at higher level ccRCC tissues than corresponding nontumor tissues. explored impact on proliferation, invasion,...
To investigate the protective effect of pioglitazone on kidney injury in diabetic rat model and its mechanisms.Forty healthy Sprague Dawley rats were selected randomly divided into five groups, with 8 each group. Group A served as control group administered sterile citrate buffer (i.p.) placebo. Groups B, C, D E injected streptozotocin to induce type I diabetes. Diabetic B intragastrically saline solution alone. given hydrochloride suspension at doses 10, 20, 30 mg/kg per day, respectively....
To evaluate the efficacy and safety of oral sitafloxacin versus levofloxacin in Chinese adults with acute uncomplicated urinary tract infection (UTI) or complicated UTI.In this randomized, active-controlled clinical trial, patients UTI were randomized to receive 100-mg once-daily (qd) 500-mg qd orally for 3-5 days. The twice daily 10-14 primary endpoint was at test-of-cure (TOC) visit.At TOC visit, cure rate 89.2% (58/65) group 97.1% (68/70) corresponding bacterial eradication (34/35) 97.6%...
Urolithiasis has become more prevalent throughout China.Knowing stone composition helps identify their possible underlying etiology of urolithiasis, provide appropriate individualized treatment and prevent recurrence.To explore characteristics urinary in China, determine the effects gender, age, body mass index (BMI), localization geographical region on composition.We used Fourier transform infrared spectroscopy to analyse stones from consecutive patients at 46 hospitals seven geographic...
Abstract Current treatments including androgen deprivation fail to prevent prostate cancer (PrCa) from progressing castration‐resistant PrCa (CRPC). Accumulating evidence highlights the relevance of prostate‐specific antigen (PSA) in development and progression PrCa. The underlying mechanism whereby PSA functions PrCa, however, has yet been elucidated. We demonstrated that knockdown attenuated tumorigenesis metastasis C4‐2 cells vitro vivo, whereas promoted apoptosis vitro. To illuminate...
A 56-year-old man with a long history of alcoholism and palpable raised mass about 23 cm × 12 in size on his neck was diagnosed Madelung’s disease (MD); the patient also had hyperuricemia. On day 1, he underwent lipoma tissue resection suddenly dyspnea 9 h after operation, which followed by cardiac arrest. After heart rate resuscitation, developed heartbeat, but remained coma died days operation. No obvious pathological tracheal compression from hematoma observed while evaluating patient’s...
The crosstalk between cuproptosis and the tumor immune microenvironment (TIME) is vital during clear cell renal carcinoma (ccRCC) malignant progression. However, underlying molecular mechanisms regulate this cross-talk remain elusive. Through tailored machine learning, we analyze clinical ccRCC data from Cancer Genome Atlas (TCGA) to explore critical factors that interaction among cuproptosis, TIME, We found rhomboid-like 2 (RHBDL2), gene affecting process, might inhibit cuproptosis-related...
Prostate cancer (PCa) is one of the most common malignant diseases urinary system and has poor prognosis after progression to castration-resistant prostate (CRPC), increased cytosine methylation heterogeneity associated with more aggressive phenotype PCa cell line. Activation-induced cytidine deaminase (AID) a multifunctional enzyme contributes antibody diversification. However, dysregulation AID participates in multiple related certain oncogenes through demethylation. Nevertheless, role...
Objective To investigate the relationship between Cyclophilin D (CypD) and occurrence development of clear cell-renal cell carcinoma (ccRCC), explore action mechanism CypD in treatment cRCC with sorafenib. Methods We used immunohistochemical analysis to compare expression human ccRCC tissues (n=53) adjacent non-cancerous (ANCT, n=34), mRNA protein differences HK-2, A498 786-O lines were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) Western blotting respectively....