A5083851179- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Ovarian function and disorders
- Ferroptosis and cancer prognosis
- Biological Activity of Diterpenoids and Biflavonoids
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Medicinal Plants and Bioactive Compounds
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Bioactive natural compounds
- Liver physiology and pathology
- ATP Synthase and ATPases Research
- Traditional Chinese Medicine Analysis
- NF-κB Signaling Pathways
- Plant-Derived Bioactive Compounds
Wuhan University
2017-2025
Renmin Hospital of Wuhan University
2020-2025
City University of Hong Kong
2022-2025
Wenzhou City People's Hospital
2024
Wenzhou Medical University
2020-2024
First Affiliated Hospital of Wenzhou Medical University
2020
Chungnam National University
2004-2009
Korea Research Institute of Bioscience and Biotechnology
2007
Catholic University of Daegu
2007
Ministry of Food and Drug Safety
2007
Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB) progression.It is great clinical implications to develop an individualized risk prognostication approach with stratification-guided therapeutic options for NB based on elucidating molecular mechanisms reprogramming.Methods: With a machine learning-based multi-step program, the synergic reprogramming-driven malignant progression were elucidated at single-cell and metabolite flux dimensions.Subsequently, promising...
Despite the many benefits immunotherapy has brought to patients with different cancers, its clinical applications and improvements are still hindered by drug resistance. Fostering a reliable approach identifying sufferers who sensitive certain immunotherapeutic agents is of great relevance.We propose an ELISE (Ensemble Learning for Immunotherapeutic Response Evaluation) pipeline generate robust highly accurate predicting individual responses immunotherapies. employed iterative univariable...
Osteoarthritis (OA) is characterized by cartilage degeneration and inflammation. Procyanidin B2 (PCB2), a natural flavonoid compound, exhibits potential anti-inflammatory anti-oxidative effects against several diseases. However, its curative on OA remain unclear.Herein, we explored the anti-arthritic of PCB2 onset progress mechanism.CCK-8 assays EdU staining were used to assess cytotoxic cell proliferation activity PCB2. Flow cytometry was detect apoptosis in chondrocytes. ELISA, qPCR,...
The immune system is closely associated with the pathogenesis of polycystic ovary syndrome (PCOS). Macrophages are one important cell types in ovarian proinflammatory microenvironment, and ameliorate inflammatory status mainly through M2 phenotype polarization during PCOS. Current therapeutic approaches lack efficacy immunomodulatory capacity, a new method needed to prevent inflammation alleviate Here, octahedral nanoceria nanoparticles powerful antioxidative ability were bonded...
Abstract Dysregulated mitophagy is essential for mitochondrial quality control within human cancers. However, identifying hub genes regulating and developing mitophagy‐based treatments to combat drug resistance remains challenging. Herein, BayeDEM (Bayesian‐optimized Deep learning Essential of Mitophagy) was proposed such a task. After Bayesian optimization, demonstrated its excellent performance in critical osteosarcoma (area under curve [AUC] ROC: 98.96%; AUC PR curve: 100%). CERS1...
Abstract Neuroblastoma (NBL) exists in a complex tumor–immune microenvironment. Immune cell infiltration and molecules play critical role tumor development significantly impact the prognosis of patients. However, molecular characteristics describing NBL–immune interaction their prognostic potential have yet to be investigated systematically. We first employed multiple machine learning algorithms, such as Gene Sets Enrichment Analysis type identification by estimating relative subsets RNA...
Background: The defense response is a type of self-protective the body that protects it from damage by pathogenic factors. Although these reactions make important contributions to occurrence and development tumors, role they play in osteosarcoma (OS), particularly immune microenvironment, remains unpredictable. Methods: This study included clinical information transcriptomic data 84 samples microarray 12 mesenchymal stem cell samples. We obtained 129 differentially expressed genes related...
Six diarylheptanoids (1—6) from the stem bark of Alnus hirsuta were investigated for their inhibitory activity against LPS-induced NF-kB activation and NO TNF-α production. Among them, compounds 2, 3, 6 displayed production with IC50 values 9.2—9.9 μM, 18.2—19.3 22.3—23.7 respectively, in RAW264.7 cells. Three active had no significant cytotoxicity cells at effective concentrations. This is first report NF-kB-inhibitory these supports pharmacological use A. hirsuta, which has been employed...
Sphingolipid metabolism (SM) fuels tumorigenesis and the malignant progression of osteosarcoma (OS), which leads to an unfavorable prognosis. Elucidating molecular mechanisms underlying SM in developing a SM-based prognostic signature could be beneficial clinical setting. This study included 88 frozen OS samples recognize vital SM-relevant genes development utilizing univariate Cox regression. The Least Absolute Shrinkage Selection Operator (LASSO) regression analysis was conducted on SM-...
Clear cell renal carcinoma (ccRCC) are typically situated in a complex inflammatory and immune microenvironment, which has been reported to contribute the unfavorable prognosis of patients with ccRCC. There would be beneficial clinical implications for elucidating roles its molecular characteristics microenvironment. This is because it facilitate development reliable biomarkers pre-stratification prior designation individualized treatment strategies. In present study, RNA-sequencing data...
Three new lignans, 4′-methoxymagndialdehyde (1), 4′-methoxymagnaldehyde B (2), and E (3), were isolated from hexane- EtOAc-soluble fractions of the stem bark Magnolia officinalis, together with eight known compounds (4–11). The structures 1–3 determined on basis spectroscopic physicochemical data analysis. Compounds 1–11 tested in vitro for their cytotoxic activity against K562, HeLa, A549 cancer cell lines. Among tested, compound 1 showed most potent these lines, IC50 values 3.9, 1.5, 3.7...
Bioassay-guided fractionation of a MeOH extract the whole plant Aceriphyllum rossii (Saxifragaceae) led to isolation two new triterpenes, 3α,23-isopropylidenedioxyolean-12-en-27-oic acid (1) and 23-hydroxy-3-oxoolean-12-en-27-oic (2), together with six known 3-oxoolean-12-en-27-oic (3), 3α-hydroxyolean-12-en-27-oic (4), β-peltoboykinolic (5), aceriphyllic A (6), oleanolic (7), gypsogenic (8). The structures these compounds were elucidated on basis physicochemical spectroscopic analyses....
Background/Aims: The apoptosis of activated hepatic stellate cells (HSCs) is the central event in reversal liver fibrosis. K63 de-ubiquitinated receptor-interacting protein (RIP)1 promotes tumor necrosis factor (TNF)-α signaling pathway. In previous study, we have proved that indole-3-carbinol (I3C) could reverse different models fibrosis rats, but mechanism still unclear. Thus, present research aimed to demonstrate induction I3C on HSCs and underlying molecular mechanism. Methods: HSC-T6,...