Coreopsis is a flowering plant belonging to the Asteraceae family. It an ornamental native Americas, Asia and Oceania its flower used as raw material for tea food manufacture in China. In this study, new cultivars of C. rosea ("golden ring") were developed via radiation-induced mutation original cultivar, "pumpkin pie". The chemical composition antioxidant activities flowers three different evaluated: "golden ring", pie" "snow chrysanthemum" (coreopsis tea; tinctoria). volatile compounds...

Cimicifugae Rhizoma has been used as a medicinal herb for fever, pain, and inflammation in East Asia. We conducted this study because the effect of extract (CRE) on allergic asthma not yet evaluated. To induce airway inflammation, we intraperitoneally injected ovalbumin (OVA) mixed with aluminum hydroxide into mice twice at intervals 2 weeks (Days 0 14) then inhaled them thrice 1% OVA solution using nebulizer 21 to 23). CRE (30 100 mg/kg) was administered orally daily 6 days 18 The showed...

Dry eyes are caused by highly increased osmolarity of tear film, inflammation, and apoptosis the ocular surface. In this study, we investigated effect Polygonum cuspidatum (PCE) aqueous extract in vivo vitro dry eye models. was induced excision lacrimal gland hyperosmotic media. vivo, oral administration PCE exorbital gland-excised rats recovered volume Mucin4 (MUC4) expression inhibiting corneal irregularity inflammatory cytokines. vitro, media human epithelial cell (HCEC) cytotoxicity...

Phytochemical study on the EtOAc-soluble fraction of stem bark Populus davidiana resulted in isolation 10 phenolic glycosides (1-10), which were identified basis physicochemical and spectroscopic analyses. Among these, three new compounds, populosides A-C (1-3), determined to be 2-coumaroylmethyl-4-hydroxyphenyl-beta-D-glucopyranoside, 2-coumaroylmethylphenyl-beta-D-glucopyranoside, 2-feruoylmethylphenyl-beta-D-glucopyranoside, respectively. Compounds 1-10 tested for their radical scavenging...

Methyl 3,5-di-caffeoylquinate (3,5-diCQM) has been used for the treatment of various diseases in oriental medicine, but its effect on melanogenesis not reported yet.In this study, molecular mechanism 3,5-diCQM-induced was investigated.It found that 3,5-diCQM induced synthesis melanin pigments murine B16F10 melanoma cells a concentrationdependent manner.Treatment with 48 h increased extracellular and intracellular production tyrosinase activity.The expressions tyrosinase, tyrosinase-related...

The melanin-inducing properties of cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which isolated from the branches Lithocarpus dealbatus. Tyrosinase activity and melanin content melanoma cells increased by a dose-dependent manner. Western blot analysis revealed that tyrosinase, tyrosinase-related protein (TRP) 1, TRP2 levels enhanced after treatment for 48 h. also upregulated expression microphthalmia-associated transcription...

Accumulating evidences suggest that aldose reductase (AR) inhibitors and advanced glycation end product (AGE) formation may prevent chronic hyperglycemia-induced long-term complication in diabetes. Transforming growth factor-beta1 (TGF-β1) plays an important role the development of diabetic nephropathy. Allium species have been utilized folk medicine throughout world for treatment various physical disorders. However, benefits victorialis (A. victorialis) against complications, especially...

Retinal capillary cell loss is a hallmark of early diabetic retinal changes. Advanced glycation end products (AGEs) are believed to contribute microvascular in retinopathy. In this study, the protective effects Aster koraiensis extract (AKE) against damage vascular cells were investigated streptozotocin (STZ)-induced rats. To examine issue further, AGE accumulation, nuclear factor-kappaB (NF-κB) and inducible nitric oxide synthase (iNOS) using trypsin digests from streptozotocin-induced...

Dry eye disease (DED) is a multifactorial inflammatory that severely impairs patients’ quality of life. Particulate matter comprises harmful mixture particles less than 10 μm in size, which on contact with the eye, causes inflammation cornea/conjunctival epithelium, threatening health and triggering onset DED. Achyranthis radix an ingredient traditional medicine generally used for treating osteoporosis, trauma, thrombosis Asian countries. However, effect has not been elucidated. In this...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT(+)-4β-Hydroxyhernandulcin, A New Sweet Sesquiterpene from the Leaves and Flowers of Lippia dulcisNorito Kaneda, Ik-Soo Lee, Mahabir P. Gupta, D. Doel Soejarto, A. Douglas KinghornCite this: J. Nat. Prod. 1992, 55, 8, 1136–1141Publication Date (Print):August 1, 1992Publication History Published online1 July 2004Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/np50086a016https://doi.org/10.1021/np50086a016research-articleACS...

Gardeniae Fructus is a traditional medicine used for the treatment of contusion such as ankle sprain. Geniposide one main components with diverse biological activities. In order to gain further insight into therapeutic action extract (GFE) and geniposide on ligament injuries, new in vitro model was developed present study. Rat hind fibroblasts (RHALFs) derived from Sprague-Dawley rats were cultured, cell proliferation collagen content examined by MTT Sirius Red-based colorimetric assay after...

A potential natural melanogenesis inhibitor was discovered in the form of a sesquiterpene isolated from flowers Inula britannica, specifically 6-O-isobutyrylbritannilactone (IBL). We evaluated antimelanogenesis effects IBL on B16F10 melanocytes and zebrafish embryos. As result, we found that 3-isobutyl-1-methylxanthine (IBMX)-induced melanin production reduced dose-dependent manner cells by IBL. also analyzed were not treated with IBMX, investigating concentration, tyrosinase activity, mRNA...

Soluble epoxide hydrolase (sEH) is an enzyme targeted for the treatment of inflammation and cardiovascular diseases. Activated inflammatory cells produce nitric oxide (NO), which induces oxidative stress exacerbates inflammation. We identify inhibitor able to suppress sEH thus NO production. Five flavonoids 1–5 isolated from Inula britannica flowers were evaluated their abilities inhibit with IC50 values 12.1 ± 0.1 62.8 1.8 µM effects on kinetics. A simulation study using computational...

Age-related ocular diseases such as age-related macular degeneration, glaucoma, and diabetic retinopathy are major causes of irreversible vision impairment in the elderly. Conventional treatments focus on symptom relief disease slowdown, often involving surgery, but fall short providing a cure, leading to substantial loss. Regenerative medicine, particularly mesenchymal stem cells (MSCs), holds promise for treatment. This study investigates synergistic potential combining placenta-derived...

A new flavonoid, 2,″4″-O-diacetylquercitrin (1), along with six known flavonoids (2–7) were isolated from the aerial parts of Melastoma sanguineum. The structure flavonoid was established by extensive spectroscopic studies and chemical evidence. inhibitory effects compounds (1–7) on advanced glycation end-products (AGEs) formation rat lens aldose reductase (RLAR) in vitro examined. Of tested compounds, compound 1 strongest inhibitor AGEs, an IC50 11.46±0.44 µm. In RLAR assay, all exhibited...

In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems leaves. These isolates (1-5) subjected an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation rat lens aldose reductase activity. All tested...