A5028003406- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Nonlinear Waves and Solitons
- Aortic Disease and Treatment Approaches
- Nonlinear Photonic Systems
- Power Systems and Renewable Energy
- Clostridium difficile and Clostridium perfringens research
- Aortic aneurysm repair treatments
- Algebraic structures and combinatorial models
- Aquatic Ecosystems and Phytoplankton Dynamics
- Antibiotic Use and Resistance
- Antifungal resistance and susceptibility
- Cardiac Valve Diseases and Treatments
- Smart Grid and Power Systems
- Pharmaceutical and Antibiotic Environmental Impacts
- Bacterial biofilms and quorum sensing
- Fungal Infections and Studies
- Bacterial Infections and Vaccines
- Fractional Differential Equations Solutions
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Mycology
- Power Systems and Technologies
Huashan Hospital
2015-2025
Fudan University
2015-2025
First Affiliated Hospital of Guangzhou Medical University
2015-2025
Guangzhou Medical University
2015-2025
Northeast Forestry University
2025
Guizhou Academy of Testing & Analysis
2019-2024
NARI Group (China)
2014-2024
Chengdu Military General Hospital
2024
Beijing Anzhen Hospital
2024
Capital Medical University
2024
Although quinolone resistance usually results from chromosomal mutations, recent studies indicate that can also be plasmid mediated. The gene responsible, qnr, is distinct the known genes and in previous seemed to restricted Klebsiella pneumoniae Escherichia coli isolates University of Alabama Birmingham, where this was discovered. In Shanghai, frequency ciprofloxacin E. has exceeded 50% since 1993. Seventy-eight unique ciprofloxacin-resistant clinical Shanghai hospitals were screened for...
Since glycopeptide-resistant enterococci (GRE) were reported in 1988, they have appeared hospitals worldwide. Seven van gene cluster types (vanA, vanB, vanC, vanD, vanE, vanG, and vanL) are currently known. We investigated a clinical strain of Enterococcus faecium Efm-HS0661 that was isolated 2006 from an inpatient with intra-abdominal infection Shanghai. It resistant to most antimicrobials, including vancomycin (MIC, >256 μg/ml) teicoplanin 96 μg/ml). Glycopeptide resistance could be...
Heteroatom doped carbon dots (CDs), with high photoluminescence quantum yield (PLQY), are of keen interest in various applications such as chemical sensors, bio-imaging, electronics, and photovoltaics. Zinc, an important element assisting the electron-transfer process essential trace for cells, is a promising metal dopant CDs, which could potentially lead to multifunctional CDs. In this contribution, we report single-step, efficiency, hydrothermal method synthesize Zn-doped (Zn-CDs) superior...
Clinical practice guidelines or recommendations often require timely and regular updating as new evidence emerges, because this can alter the risk-benefit trade-off. The scientific process of developing accompanied by adequate implementation improve outcomes. To promote better management patients receiving vancomycin therapy, we updated guideline for therapeutic drug monitoring (TDM) published in 2015.Our complied with standards trustworthy guidelines, including timeliness rigor process,...
Guideline development should be based on the quality of evidence, balance benefits and harms, economic evaluation patients' views preferences. Therefore, these factors were considered in a new guideline for therapeutic drug monitoring (TDM) vancomycin. To develop an evidence-based vancomycin TDM to promote standardized clinical practice China. We referred WHO Handbook Development used Grading Recommendations Assessment, Evaluation (GRADE) system rate evidence grade strength recommendations,...
Increasing the ceftaroline fosamil dose beyond 600 mg every 12 h may provide additional benefit for patients with complicated skin and soft tissue infections (cSSTIs) severe inflammation and/or reduced pathogen susceptibility. A Phase III multicentre, randomized trial evaluated safety efficacy of 8 in this setting. Adult cSSTI systemic or comorbidities were 2:1 to intravenous (600 h) vancomycin (15 mg/kg plus aztreonam (1 g 5–14 days. Clinical cure was assessed at test (TOC) visit (8–15 days...
Contezolid is a novel oxazolidinone antibacterial agent for managing infections caused by aerobic and anaerobic Gram-positive bacteria including methicillin-resistant strains. A Phase III, multicentre, randomized, double-blind, active-controlled trial evaluated the efficacy safety of contezolid versus linezolid in adults with complicated skin soft tissue (cSSTIs).Adult patients cSSTI were randomized ratio 1:1 to receive 800 mg or 600 q12h 7-14 days. Clinical cure rate assessed at test (TOC)...
Background Bloodstream infections (BSIs), especially hospital-acquired BSIs, are a major cause of morbidity and mortality. However, the details about pathogens antimicrobial resistance profile BSIs across China still lacking. Methods An investigation was conducted in 10 large teaching hospitals from seven geographic regions 2016 based on Antimicrobial Surveillance Network (CHINET) to clinical etiological features BSIs. Results A total 2,773 cases were identified, majority (97.3%) which...
•An inflammatory risk model is developed to predict multiple organ dysfunction syndrome (MODS) after acute type A aortic dissection (ATAAD) surgery•The differences in probabilities likely modify the association between ulinastatin use and MODS ATAAD surgery•Inflammatory stratification can help individualize anti-inflammatory pharmacotherapy, highlighting need for precision theranostics surgery The systemic benefits of pharmacotherapy vary across cardiovascular diseases clinical practice. We...
Carbapenems such as imipenem and meropenem are first-line agents for the treatment of serious nosocomial infections caused by multidrug-resistant clinical isolates bacteria belonging to family Enterobacteriaceae. However, resistance carbapenems has increased dramatically among members Enterobacteriaceae isolated from a teaching hospital in Shanghai, China. In present study, we investigated prevalence molecular characteristics carbapenem-resistant None 77 collected 2002 2009 were susceptible...
Abstract Solar‐driven interfacial water evaporation holds a broad application prospect in the domain of seawater desalination. However, traditional desalination technology is facing challenge large‐scale preparation and desalting performance. Herein, based on easy processing low cost advantages carbon‐based solar‐thermal materials, study proposes novel strategy to use surfactant Pluronic F127 encapsulate carbon black form size‐stable “core–shell” nanomicelle. Then, evaporator cross‐linked by...
Ceftazidime-avibactam was approved in patients with hospital-acquired pneumonia (HAP), including ventilator-associated (VAP), based on the multinational Phase 3 REPROVE study. This study assessed efficacy and safety of ceftazidime-avibactam Chinese adults HAP/VAP. a 4, prospective, multi-centre, open-label study, conducted at 42 sites China. Patients HAP/VAP received 2.5 g by 2-hour IV infusion every 8 hours for 7-14 days. Primary endpoint clinical response test-of-cure (TOC) visit modified...
Adequate detection of the production carbapenemase in Enterobacteriaceae isolates is crucial for infection control measures and appropriate choice antimicrobial therapy. In this study, we investigated frequency false positive results carbapenemases carbapenemase-negative Escherichia coli Klebsiella pneumoniae clinical by modified Hodge test (MHT). Three hundred one E. K. were investigated. All produced extended spectrum β-lactamases (ESBLs) but susceptible to carbapenems. Antimicrobial...
Abstract Background Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has in vitro activity against bacteria commonly encountered complicated intra-abdominal infections (cIAIs), including aerobic and facultative Gram-positive Gram-negative anaerobic bacteria. In the current trial, tigecycline was evaluated for safety efficacy vs. imipenem/cilastatin hospitalized Chinese patients with cIAIs. Methods this phase 3, multicenter, open-label study, were randomly assigned to...