A5100722101- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Influenza Virus Research Studies
- interferon and immune responses
- Inflammation biomarkers and pathways
- Antibiotic Use and Resistance
- Nosocomial Infections in ICU
- Acute Ischemic Stroke Management
- Lipid metabolism and disorders
- Pancreatitis Pathology and Treatment
- Nitric Oxide and Endothelin Effects
- Medical Imaging and Analysis
- Bone fractures and treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Immune Cell Function and Interaction
- Anesthesia and Sedative Agents
- Diabetes and associated disorders
- Antibiotic Resistance in Bacteria
- Biomarkers in Disease Mechanisms
- Spinal Fractures and Fixation Techniques
- NF-κB Signaling Pathways
China Medical University
2012-2025
First Hospital of China Medical University
2006-2025
Dongyang People's Hospital
2020-2023
Wenzhou Medical University
2020-2023
Fuyang City People's Hospital
2023
Ningbo Dahongying University
2020
National Natural Science Foundation of China
2014
Central Hospital Affiliated to Shenyang Medical College
2013
Zhengzhou University
2013
Panyu Hospital of Chinese Medicine
2004-2012
Introduction Information about sepsis in mainland China remains scarce and incomplete. The purpose of this study was to describe the epidemiology outcome severe septic shock mixed ICU China, as well independent predictors mortality. Methods We performed a 2-month prospective, observational cohort 22 closed multi-disciplinary intensive care units (ICUs). All admissions into those ICUs during period were screened patients with or included. Results A total 484 patients, 37.3 per 100 diagnosed...
Inflammatory responses can induce microvascular and endothelial dysfunction, which is associated with the development of sepsis. This study aimed at examining concentrations plasma tissue factor (TF), von Willebrand (vWF), tumor necrosis factor-α (TNF-α) in patients sepsis determining how septic (SP) regulates TF vWF expression p38 mitogen activated protein kinase (p38 MAPK)/nuclear factor-κB (NF-κB) pathways human cells. The TF, vWF, TNF-α 22 eight healthy controls (HCs) were examined by...
Abstract Background Disseminated intravascular coagulation (DIC) occurs in 30–50% of septic patients and contributes to high mortality the intensive care unit (ICU). However, there are few proven interventions for disorder management sepsis. Experimental clinical data have demonstrated that sepsis could benefit from unfractionated heparin (UFH) treatment. To date, no large multicenter trials determine safety efficacy UFH with suspected DIC. Methods A multicenter, double-blinded,...
Background Chronic critical illness (CCI) can manifest as dysfunction of thyroid hormones. This study aimed to investigate the predictive value nonthyroidal syndrome (NTIS) for prognosis CCI patients, establish a model and evaluate efficacy provide theoretical basis clinical intervention.
Abstract Background Tigecycline, a first-in-class broad-spectrum glycylcycline antibiotic, has in vitro activity against bacteria commonly encountered complicated intra-abdominal infections (cIAIs), including aerobic and facultative Gram-positive Gram-negative anaerobic bacteria. In the current trial, tigecycline was evaluated for safety efficacy vs. imipenem/cilastatin hospitalized Chinese patients with cIAIs. Methods this phase 3, multicenter, open-label study, were randomly assigned to...
Abstract Background To describe the knowledge and attitudes of critical care clinicians during 2009 H1N1 influenza pandemic. Methods A survey conducted in 21 intensive units 17 provinces China. Results Out 733 questionnaires distributed, 695 were completed. Three hundred fifty-six respondents (51.2%) reported their experience caring for patients. Despite fact that 88.5% all ultimately finished an training program, only 41.9% admitted they had influenza. total 572 (82.3%) expressed...
The Chinese guidelines for IAI presented here were developed by a panel that included experts from the fields of surgery, critical care, microbiology, infection control, pharmacology, and evidence-based medicine. All questions structured in population, intervention, comparison, outcomes format, evidence profiles generated. Recommendations generated following principles Grading Assessment, Development, Evaluation system or Best Practice Statement (BPS), when applicable. final include 45...
High mobility group box 1 (HMGB1) is a systemic inflammation‑associated cytokine mediator. The aim of the present study was to examine effect downregulation HMGB1 in lipopolysaccharide (LPS)‑induced mouse model acute lung injury (ALI). It identified that serum levels tumor necrosis factor‑α and interleukin‑1β, myeloperoxidase activity malondialdehyde content, as well wet/dry weight ratios were all increased following LPS challenge. However, LPS‑mediated increases these parameters...
To compare the clinical effects and safety of remiazolam esketamine in preoperative sedation children.
Clarify the effect of neutrophil extracellular traps (NETs) on endothelial cell injury, and investigate whether heparin can exert a protective cells by reducing injury induced NETs.Neutrophils (PMN) were obtained from healthy human peripheral blood Percoll-Histopaque density gradient centrifugation, was stimulated with phorbol ester (PMA) to induce NETs. The qualitative quantitative analysis NETs detected immunofluorescence staining combined fluorescence detector. used umbilical vein (HUVEC)...
To observe the effect of heparin on cellular morphology and expressions nitric oxide (NO) reactive oxygen species (ROS) in renal microvascular endothelial cells (RMVECs) stimulated by lipopolysaccharide (LPS).The three step gradient screen method was used to primarily culture rat RMVECs, 3rd 4th generation with excellent growth were collected. The divided into blank control group, 10 mg/L LPS treatment group 2.5, 5, kU/L pretreatment groups (the corresponding dose given 0.5 hour before...
To investigate the influence of heparin pretreatment on serum and lung tissue level neutrophil extracellular traps (NETs) in septic mice model its molecular mechanism.Ninety male C57BL/6J were randomly divided into control group (n = 30), lipopolysaccharides (LPS) 30, 30 mg/kg LPS 100 ?L normal saline was intraperitoneally injected) LPS+heparin 8 U 20 subcutaneously injected minutes before injection LPS). Six hours later injection, blood collected harvested. Enzyme linked immunosorbent assay...
<bold>CO-10</bold> induced cell apoptosis with mitochondria dysfunction and caspases, ASK1-MAPKs pathway activation.