A5070625955- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Healthcare Systems and Practices
- Antibiotic Use and Resistance
- Central Venous Catheters and Hemodialysis
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Fungal Infections and Studies
- Infective Endocarditis Diagnosis and Management
- Pancreatitis Pathology and Treatment
- Health, Medicine and Society
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Infection Control in Healthcare
- Burn Injury Management and Outcomes
- Respiratory Support and Mechanisms
- Patient Safety and Medication Errors
- Neutropenia and Cancer Infections
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Health and Medical Studies
University of Lausanne
2014-2024
University Hospital of Lausanne
2014-2023
Hôpital Orthopédique de la Suisse Romande
2005-2023
Herrenknecht (Germany)
2023
Engineering Associates (United States)
2017
Centre Hospitalier Universitaire de Sherbrooke
2015
MSD (Australia)
2015
Swiss Academy of Medical Sciences
2015
University Hospital of Geneva
1999-2014
UMass Memorial Health Care
2010
Candida species are among the most common bloodstream pathogens in United States, where emergence of azole-resistant glabrata and krusei major concerns. Recent comprehensive longitudinal data from Europe lacking. We conducted a nationwide survey candidemia during 1991–2000 17 university university-affiliated hospitals representing 79% all tertiary care hospital beds Switzerland. The number transplantations infections increased significantly (P < .001). A total 1137 episodes were observed:...
Objective To evaluate the efficacy and safety of intravenous fluconazole for prevention intra-abdominal Candida infections in high-risk surgical patients. Design Randomized, prospective, double-blind, placebo-controlled study. Setting Two university-affiliated hospitals Switzerland. Patients Forty-nine patients with recurrent gastrointestinal perforations or anastomotic leakages. Interventions Prophylaxis (400 mg per day) placebo continued until resolution underlying condition. Measurements...
In patients with ventilator-associated pneumonia (VAP), guidelines recommend antibiotic therapy adjustment according to microbiology results after 72 h. Circulating procalcitonin levels may provide evidence that facilitates the reduction of therapy. a multicentre, randomised, controlled trial, 101 VAP were assigned an discontinuation strategy (control group) or serum concentrations (procalcitonin regimen selected by treating physician. The primary end-point was antibiotic-free days alive...
Nosocomial pneumonia and sepsis, as well severe diffuse peritonitis, must be treated early in order to prevent complications such septic shock organ dysfunctions. With the availability of new broad-spectrum highly bactericidal antibiotics, need combining beta-lactams with aminoglycosides for treatment infections should reassessed. A prospective randomized controlled study was performed compare imipenem monotherapy a combination plus netilmicin empiric nosocomial pneumonia, peritonitis. total...
Rationale: Life-threatening intraabdominal candidiasis (IAC) occurs in 30 to 40% of high-risk surgical intensive care unit (ICU) patients. Although early IAC diagnosis is crucial, blood cultures are negative, and the role Candida score/colonization indexes not established.Objectives: The aim this prospective Fungal Infection Network Switzerland (FUNGINOS) cohort study was assess accuracy 1,3-β-d-glucan (BG) antigenemia for IAC.Methods: Four hundred thirty-four consecutive adults with...
Invasive candidiasis ranges from 5 to 10 cases per 1,000 ICU admissions and represents 5% 10% of all ICU-acquired infections, with an overall mortality comparable that severe sepsis/septic shock. A large majority them are due Candida albicans, but the proportion strains decreased sensitivity or resistance fluconazole is increasingly reported. high patients become colonized, only 30% develop invasive infection. Progressive colonization major abdominal surgery common risk factors, difficult...
Hypothermia impairs blood glucose homeostasis and insulin sensitivity. However, the impact of therapeutic hypothermia on levels requirements is unknown. We analyzed variability during in patients with coma after cardiac arrest examined its outcome.Prospective observational study.Two university hospital medical/surgical intensive care units.Comatose treated (33°C, 24 hrs).Insulin therapy (blood target 6-8 mmol/L [110-150 mg/dL]), according to a written algorithm, nurse-driven adjustment...
Background. Patients undergoing emergency gastrointestinal surgery for intra-abdominal infection are at risk of invasive candidiasis (IC) and candidates preemptive antifungal therapy.
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
Nosocomial pneumonia is a major source of morbidity and mortality after severe burns. Burned patients suffer trace element deficiencies depressed antioxidant immune defences. This study aimed at determining the effect supplementation on nosocomial or intensive care unit (ICU)-acquired pneumonia.Two consecutive, randomised, double-blinded, studies including two homogeneous groups 41 severely burned (20 placebo 21 intervention) admitted to burn centre university hospital were combined....
Abstract Primary bloodstream infection (BSI) is a leading, preventable infectious complication in critically ill patients and has negative impact on patients' outcome. Surveillance definitions for primary BSI distinguish those that are microbiologically documented from not. The latter known as clinical sepsis, but information its epidemiologic importance limited. We analyzed prospective on-site surveillance data of nosocomial infections medical intensive care unit. Of the 113 episodes BSI,...
Iseganan, an antimicrobial peptide, is active against aerobic and anaerobic gram-positive gram-negative bacteria as well fungi yeasts. The drug has shown little resistance in vitro to be safe tolerated 800 patients with cancer treated for up 6 wk.To determine the efficacy of iseganan prevention ventilator-associated pneumonia (VAP).Mechanically ventilated United States Europe were randomized oral topical or placebo (1:1) six times per day while intubated 14 d. Patients eligible if within 24...