A5068399463- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Bacterial Identification and Susceptibility Testing
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Infective Endocarditis Diagnosis and Management
- Airway Management and Intubation Techniques
- Neonatal and Maternal Infections
- Zoonotic diseases and public health
- S100 Proteins and Annexins
- Hemodynamic Monitoring and Therapy
- Antifungal resistance and susceptibility
- Cardiac Arrest and Resuscitation
- COVID-19 Impact on Reproduction
- Pediatric health and respiratory diseases
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Meta-analysis and systematic reviews
- COVID-19 epidemiological studies
- Hematological disorders and diagnostics
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
Inserm
2017-2024
Hôpital Dupuytren
2019-2024
Université de Limoges
2017-2024
Centre Hospitalier Universitaire de Limoges
2019-2022
Hôpital Universitaire Dupuytren
2019
Marqués de Valdecilla University Hospital
2017
Instituto de Investigación Marqués de Valdecilla
2017
BackgroundThe characteristics and course of endotracheal secretions have scarcely been studied in patients under mechanical ventilation (MV) at risk developing ventilator-associated pneumonia (VAP).Research QuestionCan be exhaustively described what is their predictive value for the diagnosis VAP during MV?Study Design MethodsThis single-center prospective study included neuro-injured with neurologic injury requiring MV least 7 days. Patients pulmonary infectious diseases were ineligible....
Urinary tract infection (UTI) is frequently diagnosed in the Emergency Department (ED). Staphylococcus aureus (SA) an uncommon isolate urine cultures (0.5–6% of positive cultures), except patients with risk factors for urinary colonization. In absence factors, community-acquired SA bacteriuria may be related to deep-seated including infective endocarditis. We hypothesized that could a warning microbiological marker unsuspected endocarditis ED. This retrospective chart review consecutive...
ABSTRACT Study Objective: We evaluated the early hemodynamic profile of patients presenting with acute circulatory failure to Emergency Department (ED) using focused echocardiography performed by emergency physicians after a dedicated training program. Methods: Patients ED an any origin were successively examined recently trained physician and expert in critical care echocardiography. Operators independently interpreted online echocardiographic examinations determine leading mechanism...
Abstract During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) 15 associated pulmonary infections intensive care unit (ICU) patients hospitalized for an acute respiratory distress syndrome (ARDS) related to SARS-CoV-2. Patients infection had a peak of IGs. thresholds 18% or 2 G/L allowed discriminating ventilator...
We investigated the performance of Xpert methicillin-resistant Staphylococcus aureus (MRSA)/ S. skin and soft tissue (SSTI) quantitative PCR (qPCR) assay in SAATELLITE, a multicenter, double-blind, phase 2 study suvratoxumab, monoclonal antibody (MAb) targeting alpha-toxin, for reducing incidence pneumonia.
More than half of patients under mechanical ventilation in the intensive care unit (ICU) are field-intubated, which is a known risk factor for ventilator associated pneumonia (VAP). We assessed whether field endobronchial intubation (EBI) with development subsequent VAP during ICU stay. This retrospective, nested case-control study was conducted cohort field-intubated admitted to an teaching hospital three-year period. Cases were defined as EBI and controls corresponded proper position...
In the Emergency Department (ED), early and accurate recognition of infection is crucial to prompt antibiotic therapy but initial presentation patients variable poorly characterized. Lymphopenia commonly associated with bacteraemia poor outcome in intensive care unit patients. The objective this retrospective study was assess prevalence community-acquired a cohort unselected admitted ED undifferentiated symptoms severe lymphopenia.This single-center conducted over 1 year-period before...
Abstract Background Staphylococcus aureus (SA) pneumonia imposes significant morbidity and mortality in mechanically ventilated, intensive care unit (MV ICU) patients despite best clinical care. We assessed efficacy, PK, AT-neutralizing antibodies (AT NAbs), safety of suvratoxumab (suvra) MV ICU subjects the placebo-controlled, randomized Phase 2 SAATELLITE study (NCT02296320; EudraCT 2014-001097-34). Methods Subjects with PCR-confirmed SA colonization lower respiratory tract were to either...
Septic patients with worst clinical prognosis have increased circulating immature granulocytes (IG), displaying limited phagocytosis and reactive oxygen species (ROS) production. Here, we developed an
Abstract Background Patients with lower airway Staphylococcus aureus (SA) colonization are at great risk (> 20%) of early-onset ventilator-associated pneumonia (VAP). Thus, a rapid test is required to identify patients risk. Suvratoxumab (formerly MEDI4893) human monoclonal antibody that neutralizes SA alpha toxin. SAATELLITE, phase 2 study safety and efficacy suvratoxumab for reducing the incidence (NCT02296320) was conducted recently completed within consortium Combatting Bacterial...
Le développement d’anticorps monoclonaux (mAbs) à visée anti-infectieuse s’est accentué ces dix dernières années avec différentes indications thérapeutiques mais principalement pour prévenir les pneumopathies acquises sous ventilation mécanique (PAVM). Cette complication infectieuse demeure une des préoccupations majeures dans services de réanimation où son incidence reste élevée. L’utilisation mAbs apparaît particulièrement adaptée cette indication au vu leur profil sécurité, cibles...