A5085402856- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Blood transfusion and management
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Transplantation: Methods and Outcomes
- Hemodynamic Monitoring and Therapy
- Enhanced Recovery After Surgery
- Trauma and Emergency Care Studies
- Cardiac and Coronary Surgery Techniques
- Airway Management and Intubation Techniques
- Hemostasis and retained surgical items
- Intensive Care Unit Cognitive Disorders
- Cardiac Valve Diseases and Treatments
- Blood properties and coagulation
- Tracheal and airway disorders
- Colorectal Cancer Surgical Treatments
- Infective Endocarditis Diagnosis and Management
- Surgical site infection prevention
- Pneumonia and Respiratory Infections
- Organ Transplantation Techniques and Outcomes
University Hospital in Motol
2009-2024
Charles University
2014-2024
Vuab Pharma (Czechia)
2022
Creative Commons
2020
Ministry of Health
2020
Weatherford College
2020
Karlovac University of Applied Sciences
2020
Opća bolnica Karlovac
2020
Massachusetts General Hospital
2019
Resuscitation Council
2019
COVID-19, caused by SARS-CoV-2 virus, emerged as a pandemic disease posing severe threat to global health. To date, sporadic studies have demonstrated that innate immune mechanisms, specifically neutrophilia, NETosis, and neutrophil-associated cytokine responses, are involved in COVID-19 pathogenesis; however, our understanding of the exact nature this aspect host–pathogen interaction is limited. Here, we present detailed dissection features functional profiles neutrophils, dendritic cells,...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
Background: Extracorporeal membrane oxygenation (ECMO) is frequently used during lung transplantation. Unfractionated heparin (UFH) mainly as part of ECMO support for anticoagulation. One the most common perioperative complications bleeding, which high-dose UFH can aggravate. Methods: We retrospectively analyzed ( n = 141) patients who underwent transplantation between 2020 and 2022. All subjects 109) central cannulated VA with successful intraoperative weaning. Patients on bridge,...
We report a case of an 8-year-old girl who underwent SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this what is sometimes described as Paediatric Inflammatory Multisystem Syndrome Temporally associated SARS-COV-2 (PIMS-TS) we documented excellent clinical...
Abstract Background Primary graft dysfunction (PGD) after lung transplantation (LuTx) contributes substantially to early postoperative morbidity. Both intraoperative transfusion of a large amount blood products during the surgery and ischemia–reperfusion injury allograft implantation play an important role in subsequent PGD development. Methods We have previously reported randomized clinical trial 67 patients where point care (POC) targeted coagulopathy management administration 5% albumin...
All European countries need to increase the number of health professionals in near future. Most efforts have not brought expected results so far. The current notion is that this mainly related fact female physicians will clearly outnumber their male colleagues within a few years nearly all countries. Still, women are underrepresented leadership and research positions throughout Europe.The MedGoFem project addresses multiple perspectives with participation stakeholders. goal facilitate...
Coagulopathy is often accompanied by prolongation of prothrombin time (PT) in septic and nonseptic patients intensive care unit (ICU). The conventional way to correct the coagulopathy administer fresh frozen plasma (FFP) before invasive procedures minimise risk bleeding. However, prolonged PT can be present even hypercoagulation status, resulting unnecessary administration FFP. In study, we have assessed reliability thromboelastometry case relationship bleeding complications during surgical...
Airway management in tracheal resections presents many challenges. The aim of this retrospective analysis is to report the efficacy and complications associated with use laryngeal mask airway procedure.The charts 54 consecutive patients operated for stenosis during period 2009-2016 were reviewed. This cohort included only trachea. We evaluated total success rate insertion (%), on first attempt, quality intraoperative ventilation through mask, fibre optic view device, incidence bleeding 24 h,...
Myasthenia gravis (MG) is an autoimmune disease interfering with neuromuscular transmission. Patients are at risk of postoperative residual curarization (PORC) if nondepolarizing muscle relaxants used. Clinically inapparent insufficient strength may result in hypoventilation and bronchopneumonia. We describe a cohort 117 cases which sugammadex was used MG patients undergoing surgery relaxation rocuronium.We anesthetized using rocuronium as blockade reversal agent. One hundred five underwent...
Hydroxyethyl starch (HES) solutions are used for volume therapy to treat hypovolemia due acute blood loss and maintain hemodynamic stability. This study was requested by the European Medicines Agency (EMA) provide more evidence on long-term safety efficacy of HES in perioperative setting.
Pulmonary alveolar proteinosis is a rare disorder that characterized by large accumulation of lipoproteinaceous material within the alveoli. This causes respiratory failure due to restriction gas exchange and changes in ventilation/perfusion ratio. Clinical symptoms are variable depend on severity damage lung parenchyma. Treatment method whole-lung lavage, where accumulated removed using quantities saline. case report describes 45 year old patient with advanced pulmonary proteinosis. Due...
Sternal dehiscence following cardiac surgery has a multifactorial etiology. Significant risk factors contributing to sternal include chronic obstructive pulmonary disease (COPD), obesity, or re-exploration due bleeding pericardial tamponade. We have focused on the role of allogeneic blood transfusion as factor leading poor healing surgical wounds. A prospective observational study 1553 elective and emergency patients was performed between January 2003 June 2007. All enrolled in this...
Fluid resuscitation with crystalloid and colloid solutions is a common treatment in perioperative medicine. However, variety of unbalanced or balanced are used clinical practice there still vivid debate going on regarding selection optimal fluid minimal negative effect coagulation to minimize bleeding blood transfusion requirements. The aim the study was investigate adverse effects crystalloids colloids measured by thromboelastometry vitro.Blood samples were obtained from healthy volunteers...
Paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS) is a new disease in children and adolescents that occurs after often asymptomatic or mild COVID-19. It can be manifested by different clinical symptomatology varying severity of based on multisystemic inflammation. The aim this retrospective cohort trial was to describe the initial presentation, diagnostics, therapy outcome paediatric patients diagnosis PIMS-TS admitted one 3 PICUs. All who were...