A5105269767- Healthcare Policy and Management
- Pharmaceutical industry and healthcare
- Corporate Taxation and Avoidance
- Primary Care and Health Outcomes
- Immunotherapy and Immune Responses
- Biomedical Ethics and Regulation
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Health and Medical Research Impacts
- Housing, Finance, and Neoliberalism
- Immune Response and Inflammation
- Healthcare Systems and Challenges
- vaccines and immunoinformatics approaches
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Online and Blended Learning
- Hormonal and reproductive studies
- Pharmaceutical Economics and Policy
- Ethics in Clinical Research
- Obesity, Physical Activity, Diet
- Global Public Health Policies and Epidemiology
- Medical Malpractice and Liability Issues
- Race, History, and American Society
- Healthcare cost, quality, practices
- Neuroscience and Neuropharmacology Research
Utica College
2020
SUNY Upstate Medical University
2020
AstraZeneca (United States)
2020
Seattle University
2013-2016
Serimmune (United States)
2016
Gannon University
2015
Institut de Recherche Vaccinale
2015
Johns Hopkins University
2010
Oregon Health & Science University
2000
Johnson University
1992-1996
ABSTRACT Borrelia burgdorferi , the spirochete that causes Lyme disease, binds decorin, a collagen-associated extracellular matrix proteoglycan found in skin (the site of entry for spirochete) and many other tissues. Two borrelial adhesins recognize this proteoglycan, decorin binding proteins A B (DbpA DbpB, respectively), have recently been identified. Infection mice by low-dose B. challenge elicited antibodies against DbpA DbpB were sustained at high levels, suggesting these antigens are...
The human papillomavirus (HPV) capsid is primarily composed of a structural protein denoted L1, which forms both pentameric capsomeres and capsids 72 capsomeres. L1 alone capable self-assembly in vivo into capsidlike structures referred to as viruslike particles (VLPs). We have determined conditions for the quantitative disassembly purified HPV-11 VLPs level capsomeres, demonstrating that disulfide bonds are essential maintaining long-term VLP structure at physiological ionic strength....
Palivizumab is a US Food and Drug Administration-approved monoclonal antibody for the prevention of respiratory syncytial virus (RSV) lower disease in high-risk infants. Motavizumab, derived from palivizumab with enhanced antiviral activity, has recently been tested humans. Although escape mutants have generated laboratory, development resistant RSV patients receiving not reported previously.
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. is the product chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while retaining adequate immunogenicity. Despite virtually unlimited number potential sources among strains, useable compounds within this promising class adjuvants few. We developed enzymatic combinatorial...
Oil-in-water emulsions have gained consideration as vaccine adjuvants in recent years due to their ability elicit a differentiated immunogenic response compared traditional aluminum salt adjuvants. Squalene, cholesterol precursor, is natural product with immunostimulatory properties, making it an ideal candidate for such oil-in-water emulsions. Particle size key parameter of these and its relationship stability adjuvanticity has not been extensively studied. This study evaluates the effect...
Respiratory syncytial virus (RSV) infection of children previously immunized with a nonlive, formalin-inactivated (FI)-RSV vaccine has been associated serious enhanced respiratory disease (ERD). Consequently, detailed studies potential ERD are critical step in the development nonlive RSV vaccines targeting RSV-naive and infants. The fusion glycoprotein (F) either its postfusion (post-F) or prefusion (pre-F) conformation is target for neutralizing antibodies therefore an attractive antigen...
Human metapneumovirus (hMPV) is a recently described member of the Paramyxoviridae family/Pneumovirinae subfamily and shares many common features with respiratory syncytial virus (RSV), another same subfamily. hMPV causes tract illnesses that, similar to human RSV, occur predominantly during winter months have symptoms that range from mild severe cough, bronchiolitis, pneumonia. Like can be subdivided into two genetic subgroups, A B. With single monoclonal antibody directed at fusion (F)...
Effective trauma resuscitation requires efficient and coordinated care from a team of providers; however, providers are rarely instructed on how to be effective members teams. Team-based learning using Team Strategies Tools Enhance Performance Patient Safety (TeamSTEPPS) has been shown improve dynamics among practicing professionals, including physicians nurses. The impact TeamSTEPPS students being trained in management an undergraduate health professional program is currently unknown. We...
Respiratory syncytial virus (RSV) is the most common cause of serious viral bronchiolitis in infants, young children, and elderly. Currently, there not an FDA-approved vaccine available for RSV, though mAb palivizumab licensed to reduce incidence RSV disease premature or at-risk infants. The epitope a well-characterized, approximately 24-aa helix-loop-helix structure on fusion (F) protein (F254–277). Here, we genetically inserted this multiple site variants within versatile woodchuck...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational states of the nicotinic acetylcholine receptor from Torpedo californica induced by binding agonists, antagonists, and local anesthetics. Equilibrium measurements using tritium-hydrogen exchangeMichael P. McCarthy Robert M. StroudCite this: Biochemistry 1989, 28, 1, 40–48Publication Date (Print):January 10, 1989Publication History Published online1 May 2002Published inissue 10 January 1989https://doi.org/10.1021/bi00427a007Request...
Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty inducing strong and sustained cytotoxic T lymphocyte (CTL) responses in patients. Several peptide-based cancer have failed show sustainable tumor regression clinic, possibly because a lack optimization both adjuvant antigen components preparations. Here, we aimed develop optimize vaccine format utilizing synthetic long...
The hydrophobic, photoreactive probe 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine ([125I]TID) was used to characterize the effects of lipids and detergents on acetylcholine receptor (AChR) conformation. Affinity purified AChR reconstituted into dioleoylphosphatidylcholine (DOPC), dioleoylphosphatidic acid (DOPA), cholesterol showed same pattern [125I]TID-labeling demonstrated reduction in labeling all four subunits upon desensitization by agonist carbamylcholine, as partially native...
Human metapneumovirus (hMPV) is genetically related to respiratory syncytial virus (RSV); both cause tract illnesses ranging from a mild cough bronchiolitis and pneumonia. The F protein-directed monoclonal antibody (mAb) palivizumab has been shown prevent severe lower RSV infection in animals humans. We have previously reported on panel of mAbs against the hMPV protein that neutralize vitro and, two cases, vivo. Here we describe generation mAb-resistant mutants (MARMs) these neutralizing...
ABSTRACT Many laboratories use a commercial enzyme immunoassay (EIA) with verification testing to diagnose Chlamydia trachomatis infections in an effort contain costs. This study was designed compare the performance and cost-effectiveness of direct fluorescent-antibody assay (DFA), PCR, ligase chain reaction (LCR) for EIA results. Cervical specimens were screened by EIA. DFA, LCR compared as tests EIA-reactive negative greyzone (NGZ) at 50% below cutoff value. These samples also tested...
Users of mobile health and fitness apps should not assume that any their data is private or protected, says a report by the Privacy Rights Clearinghouse, non-profit privacy group based in San Diego, California.1 For group’s researchers studied policies protections 43 popular apps, including allow users to enter information about diet, daily exercise routines, medical mental conditions; look up disease drug information; share with friends through app, website, social media sites such as...
The effect of the steroidal androgen receptor antagonist Win 49,596 on prostate and testis was studied in beagle dogs compared to effects nonsteroidal ICI 176,334 5αreductase inhibitor MK-906. shown bind from normal canine with a Ki 2.2 μM. After 16 weeks treatment, size, as estimated by transrectal ultrasonography, unchanged intact controls 26% initial size castrate controls. Oral doses 0.625–40 mg/kg-day for caused dose-dependent prostatic regression dose-related increase both incidence...
No AccessJournal of Urology1 Mar 1990Identification and Significance Dysmorphic Versus Isomorphic Hematuria Jeanie Sayer, Michael P. McCarthy, Joseph D. Schmidt SayerJeanie Sayer More articles by this author , McCarthyMichael McCarthy SchmidtJoseph View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)40015-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail may be glomerular or nonglomerular origin. erythrocytes...