A5015767558- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Meta-analysis and systematic reviews
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Enterobacteriaceae and Cronobacter Research
- Pharmaceutical and Antibiotic Environmental Impacts
- Nosocomial Infections in ICU
- Health Systems, Economic Evaluations, Quality of Life
- Sepsis Diagnosis and Treatment
- Ethics in Clinical Research
- Salmonella and Campylobacter epidemiology
- Pediatric Pain Management Techniques
- Gut microbiota and health
- Central Venous Catheters and Hemodialysis
- Vector-borne infectious diseases
- Clostridium difficile and Clostridium perfringens research
- Autoimmune Bullous Skin Diseases
- Burn Injury Management and Outcomes
- Mycobacterium research and diagnosis
- Clinical Laboratory Practices and Quality Control
- Bacterial Infections and Vaccines
- Data Quality and Management
University Hospital of Geneva
2022-2025
World Health Organization
2023-2025
Rambam Health Care Campus
2018-2023
Technion – Israel Institute of Technology
2016-2021
We aimed to investigate risk factors for mortality among older adults (≥ 75 years) with hospital-acquired bloodstream infections (HA-BSI) in the intensive care unit (ICU). included patients aged ≥ years HA-BSI ICU from EUROBACT-2 cohort (2019–2021). Univariable and multivariable analyses were conducted identify predictors of 28-day mortality. The 563 (median age 80, 39% women). Mortality at 28 day was 50%. Factors associated multivariate analysis admission due COVID-19, failure achieve...
Abstract Purpose Blood culture contamination (BCC) is mainly caused by commensal bacteria, during sample collection. It results in unnecessary antibiotic exposure, prolonged hospitalisation, additional microbiology workup and significant adverse health-economic burden. We aimed to investigate the short- long-term impact of COVID-19 pandemic on incidence BCC. Methods conducted a retrospective, observational cohort study at Geneva University Hospitals (HUG). included all BCCs from January 2018...
Adverse drug reactions (ADRs) are common. In the absence of a sufficiently sensitive and specific laboratory test, identification culprit remains diagnostic challenge. Patch tests have recently been advocated as means detecting sensitivity.To further elucidate usefulness patch in revealing causative drugs cutaneous ADRs (CADRs).We conducted non-blinded, prospective, controlled clinical trial. Twenty-five patients with history CADRs were tested, 25 healthy subjects who had never experienced...
Abstract Background Carbapenem-resistant Enterobacterales (CRE) infections have a significant morbidity and mortality toll. The clinical significance associated burden of CRE colonization rather than infection state are not frequently investigated. We aimed to assess the outcomes colonized patients compared matched controls. Methods A secondary analysis 1:2 case–control study at tertiary hospital in northern Israel (January-2014 June-2017). Cases were adults who newly acquired during...
A One Health approach requires integrative research to elucidate antimicrobial resistance (AMR) in the environment and risks it poses human health. Research on this topic involves experts from diverse backgrounds professions. Shortcomings exist terms of consistent, complete, transparent reporting many environmental studies. Standardized will improve quality scientific papers, enable meta-analyses enhance communication among different experts. In study, we aimed generate a consensus standards...
Mupirocin-based decolonization of Staphylococcus aureus carriers undergoing haemodialysis is not widely implemented due to concerns mupirocin resistance. In our unit, a strategy combining universal S. screening with targeted mupirocin-based was introduced two decades ago. this study patients, resistance assessed in blood and colonizing isolates during periods. Mupirocin infrequent both isolates. Furthermore, the years 2003-2021, decreasing trend annual rate bloodstream infections observed....
To reduce antimicrobial resistance (AMR), pathogen-specific AMR burden data are crucial to guide target selection for research and development of vaccines monoclonal antibodies (mAbs). We identified knowledge gaps through previously conducted systematic reviews, which informed a Delphi expert consultation on future priorities harmonisation strategies support data-driven decision-making. Consensus (≥80% agreement) importance feasibility topics was achieved in two rounds, involving 24 39 19...
Our goal was to define risk factors for limb (leg) surgical site infections (SSIs) following coronary artery bypass grafting (CABG) with open saphenous vein and estimate their consequences patients.We performed a retrospective cohort study in primary tertiary hospital Israel that included all adult patients undergoing CABG harvesting (November 2014-August 2016). Patients were followed perioperatively from admission until 90 days postoperatively, including post-discharge follow-up. Operative...
CONTEXTE ET OBJECTIFSLe fardeau de l'antibiorésistance reste peu étudié en Afrique subsaharienne (ASS).Les entérobactéries comptent parmi les principales bactéries responsables sepsis chez enfants ASS.Notre étude s'intéresse à la proportion d'entérobactéries résistantes dans cette population.Cette méta-analyse comprend un deuxième volet, présenté autre abstract, concernant colonisation par des multi-résistantes.
Introduction: Reports regarding the external validity of randomized controlled trials (RCTs) are scarce. We aimed to assess population an investigator-initiated RCT on duration antibiotics for treatment Gram-negative bacteremia by comparing patients included in that were not trial. Methods: Hospitalized with recruited into and receive 7 or 14 days covering antibiotic therapy Israel Italy from 2013 2017. In a concomitant observational study, participants compared who fulfilled inclusion...