A5072368631- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 detection and testing
- Respiratory viral infections research
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- Virus-based gene therapy research
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Viral Infections and Immunology Research
- Virology and Viral Diseases
- Animal Disease Management and Epidemiology
- Biosensors and Analytical Detection
- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- COVID-19 and Mental Health
- Vector-borne infectious diseases
- Tuberculosis Research and Epidemiology
- Zoonotic diseases and public health
- Antibiotic Resistance in Bacteria
- Viral-associated cancers and disorders
- Vibrio bacteria research studies
- Mosquito-borne diseases and control
- Climate Change and Health Impacts
Erasmus MC
2014-2025
Erasmus University Rotterdam
2014-2025
Deltares
2023
World Health Organization Regional Office for Africa
2019
European Centre for Disease Prevention and Control
2017-2019
Finnish Institute for Health and Welfare
2017-2019
National Institute for Public Health and the Environment
2011-2018
Central Veterinary Research Laboratory
2014
Utrecht University
2014
Euroimmun Medizinische Labordiagnostika (Germany)
2014
Globally, surveillance systems showed an increase in norovirus activity late 2012. Molecular data shared through the NoroNet network suggest that this is related to emergence of a new genotype II.4 variant, termed Sydney Healthcare institutions are advised be prepared for severe season.
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) has caused an ongoing outbreak of severe acute tract infection in humans the Arabian Peninsula since 2012. Dromedary camels have been implicated as possible viral reservoirs. We used serologic assays to analyze 651 dromedary camel serum samples from United Arab Emirates; 151 were obtained 2003, well before onset current epidemic, and 500 2013. Recombinant spike protein–specific immunofluorescence virus neutralization tests...
In the winter of 2014/15 a novel GII.P17-GII.17 norovirus strain (GII.17 Kawasaki 2014) emerged, as major cause gastroenteritis outbreaks in China and Japan. Since their emergence these viruses have replaced previously dominant GII.4 genotype Sydney 2012 variant some areas Asia but were only detected limited number cases on other continents. This perspective provides an overview available information GII.17 order to gain insight viral host characteristics this genotype. We further discuss...
Abstract Emerging viral infections can be identified by using a metagenomics approach for clinical human material. Diarrhea samples of patients with unexplained gastroenteritis from the Netherlands were analyzed metagenomics. Novel circular DNA viruses, bufaviruses, and genogroup III picobirnaviruses identified. These data expand our knowledge virome.
Abstract Rapid detection of infection is essential for stopping the spread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The Roche SD Biosensor rapid antigen test SARS-CoV-2 was evaluated in a nonhospitalized symptomatic population. We rapid-tested sample onsite and compared results with those from reverse transcription PCR virus culture. analyzed date onset symptoms using data clinical questionnaire. Overall sensitivity 84.9% (95% CI 79.1–89.4) specificity 99.5% 98.7–99.8)....
An increase of acute hepatitis unknown aetiology has been reported among children in multiple countries worldwide. With a rapid online survey hospitals and outside Europe, we describe case numbers recorded from 1 January to 18 April 2022 vs the previous 5 years. Of 24 that responded, identified 5/17 European 1/7 non-European with an elevation probable cases unexplained hepatitis, severe were elevated five countries.
Analysis of complete capsid sequences the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated a single haplotype since initial emergence in China late 2014. Global spread sublineage SL2 was identified. A new SL3 emerged 2016.
Abstract The WHO African region is characterised by the largest infectious disease burden in world. We conducted a retrospective descriptive analysis using records of all outbreaks formally reported to 2018 Member States region. analysed spatio-temporal distribution, notification delay as well morbidity and mortality associated with these outbreaks. In 2018, 96 new were across 36 47 States. most commonly outbreak was cholera which accounted for 20.8% ( n = 20) events, followed measles 11,...
ObjectivesCulture-based assays are currently the reference standard for drug susceptibility testing Mycobacterium tuberculosis. They provide good sensitivity and specificity but time consuming. The objective of this study was to evaluate whether whole genome sequencing (WGS), combined with software tools data analysis, can replace routine culture-based M. tuberculosis.MethodsM. tuberculosis cultures sent Finnish mycobacterial laboratory in 2014 (n = 211) were phenotypically tested by...
BackgroundSARS-CoV-2 RT-PCR assays are more sensitive than rapid antigen detection (RDT) and can detect viral RNA even after an individual is no longer infectious. RDT reduce the time to test results might better correlate with infectiousness.AimWe assessed ability of five identify infectious COVID-19 cases systematically recorded turnaround testing.MethodsSensitivity was determined using a serially diluted SARS-CoV-2 stock known concentration. The probability detecting virus at given load...
Abstract The COVID-19 pandemic proved how sharing of genomic sequences in a timely manner, as well early detection and surveillance variants characterization their clinical impacts, helped to inform public health responses. However, the area (re)emerging infectious diseases our global connectivity require interdisciplinary collaborations happen at local, national international levels connecting data understand linkages between all factors involved. Here, we describe experiences lessons...
There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies 5 avian virus antigens, using a protein microarray. General-population antibody titers against subtype H7 higher than H5 and lower H9. The highest were observed subtypes. Titers antigens increased with age geometric mean titer antigens. differences between the urban rural location our study.
Bats are likely natural hosts for a range of zoonotic viruses such as Marburg, Ebola, Rabies, well various Corona- and Paramyxoviruses. In 2009/10, researchers discovered RNA two novel influenza virus subtypes – H17N10 H18N11 in Central South American fruit bats. The identification bats possible additional reservoir A raises questions about the role this mammalian taxon ecology public health relevance. As molecular testing can be limited by short time window which is present, serological...
The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or is not well understood.We compared profiles responses 32 naturally infected subjects and 98 vaccinated with a 2009 A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), without history vaccination. Antibodies were measured hemagglutination inhibition (HI) assay for A(H1N1)pdm09 protein microarray (PA) using HA1 subunit seven recent historic H1, H2 H3 viruses, three avian...
Abstract We present an in-depth analysis of data from drive through testing stations using rapid antigen detection tests (RDT’s), RT-PCR and virus culture, to assess the ability RDT’s detect infectious cases. show that limits five commercially available differ considerably, impacting translation into recommend careful fit-for-purpose before implementation in routine algorithms as part COVID-19 response.
Abstract Background Rapid detection of infectious individuals is essential in stopping the further spread SARS-CoV-2. Although rapid antigen test not as sensitive gold standard RT-PCR, time to result decreased by day(s), strengthening effectiveness contact tracing. Methods The Roche/SD Biosensor lateral flow was evaluated a mild symptomatic population at large drive through testing site. A second nasopharyngeal swab directly tested with on site and results were compared RT-PCR virus culture....
The genus Norovirus comprises large genetic diversity, and new GII.4 variants emerge every 2-3 years. It is unknown in which host these originate. Here we study whether prolonged shedders within the immunocompromised population could be a reservoir for newly emerging strains.Sixty-five fecal samples from 16 patients were retrospectively selected. Isolated viral RNA was enriched by hybridization with custom norovirus whole-genome bait set deep sequenced on Illumina MiSeq platform.Patients...
Background Performance of the SD Biosensor saliva antigen rapid test was evaluated at a large designated testing site in non-hospitalized patients, with or without symptoms. Method All eligible people over 18 years age presenting for booked appointment SARS-CoV-2 were approached inclusion and enrolled following verbal informed consent. One nasopharyngeal swab taken to carry out default from which results reported back patient one sample self-taken according instruction on site. This used...