A5026604447- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Intensive Care Unit Cognitive Disorders
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Emergency and Acute Care Studies
- Cardiac Arrest and Resuscitation
- Healthcare Decision-Making and Restraints
- Clostridium difficile and Clostridium perfringens research
- Family and Patient Care in Intensive Care Units
- Airway Management and Intubation Techniques
- Antifungal resistance and susceptibility
- Hemodynamic Monitoring and Therapy
- Inhalation and Respiratory Drug Delivery
- Anesthesia and Sedative Agents
- Streptococcal Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Palliative Care and End-of-Life Issues
- Machine Learning in Healthcare
Washington University in St. Louis
2016-2025
Australian and New Zealand Intensive Care Society
2020-2024
University of Missouri–St. Louis
2009-2021
Ibero American University
2019-2021
Barnes-Jewish Hospital
2008-2019
Society for Healthcare Epidemiology of America
2010-2019
University of Iowa
2018
Cooper University Hospital
2018
Cooper Medical School of Rowan University
2018
Engineering Associates (United States)
2017-2018
Fungal bloodstream infections are associated with significant patient mortality and health care costs. Nevertheless, the relationship between a delay of initial empiric antifungal treatment until blood culture results known clinical outcome is not well established. A retrospective cohort analysis automated medical records pharmacy database at Barnes-Jewish Hospital was conducted. One hundred fifty-seven patients Candida infection were identified over 4-year period (January 2001 through...
The most recent European guidelines and task force reports on hospital-acquired pneumonia (HAP) ventilator-associated (VAP) were published almost 10 years ago. Since then, further randomised clinical trials of HAP VAP have been conducted new information has become available. Studies epidemiology, diagnosis, empiric treatment, response to antibiotics or forms antibiotic administration disease prevention changed old paradigms. In addition, important differences between approaches in Europe the...
Objective: To compare a practice of protocol-directed sedation during mechanical ventilation implemented by nurses with traditional non-protocol-directed administration. Design: Randomized, controlled clinical trial. Setting: Medical intensive care unit (19 beds) in an urban teaching hospital. Patients: Patients requiring (n = 321). Interventions: were randomly assigned to receive either 162) or 159). Measurements and Main Results: The median duration was 55.9 hrs (95% confidence interval,...
Objective To compare a practice of protocol-directed weaning from mechanical ventilation implemented by nurses and respiratory therapists with traditional physician-directed weaning. Design Randomized, controlled trial. Setting Medical surgical intensive care units in two university-affiliated teaching hospitals. Patients requiring (n = 357). Interventions were randomly assigned to receive either 179) or 178) ventilation. Measurements Main Results The primary outcome measure was the duration...
To identify factors associated with the development of ventilator-associated pneumonia (VAP) and to examine incidence VAP in different intensive care unit (ICU) populations.An inception cohort study.Barnes Hospital, St Louis, Mo, an academic tertiary center.A total 277 consecutive patients required mechanical ventilation for longer than 24 hours from a medical ICU (75 patients), surgical (100 or cardiothoracic (102 patients).Prospective patient surveillance data...
<h3>Importance</h3> Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about types of infections, causative pathogens, and outcomes can aid development policies for prevention, diagnosis, treatment, resource allocation may assist design interventional studies. <h3>Objective</h3> To provide prevalence infection available resources ICUs worldwide. <h3>Design, Setting, Participants</h3> Observational 24-hour point study with longitudinal follow-up at...
Objective To determine the attributable cost of ventilator-associated pneumonia from a hospital-based perspective, after adjusting for potential confounders. Design Patients admitted between January 19, 1998, and December 31, 1999, were followed prospectively occurrence pneumonia. Hospital costs defined by using hospital accounting database. Setting The medical surgical intensive care units at suburban, tertiary hospital. requiring >24 hrs mechanical ventilation. Interventions None....
Background. Post hoc analyses of clinical trial data suggested that linezolid may be more effective than vancomycin for treatment methicillin-resistant Staphylococcus aureus (MRSA) nosocomial pneumonia. This study prospectively assessed efficacy and safety linezolid, compared with a dose-optimized regimen, MRSA
Pseudomonas aeruginosa bloodstream infection is a serious with significant patient mortality and health-care costs. Nevertheless, the relationship between initial appropriate antimicrobial treatment clinical outcomes not well established. This study was retrospective cohort analysis employing automated medical records pharmacy database at Barnes-Jewish Hospital. Three hundred five patients P. were identified over 6-year period (January 1997 through December 2002). Sixty-four (21.0%) died...
Objective To evaluate a clinical guideline for the treatment of ventilator-associated pneumonia. Design Prospective before-and-after study design. Setting A medical intensive care unit from university-affiliated, urban teaching hospital. Patients Between April 1999 and January 2000, 102 patients were prospectively evaluated. Interventions patient surveillance, data collection, implementation an antimicrobial Measurements Main Results The main outcome evaluated was initial administration...
Background. Delayed treatment of candidemia has previously been shown to be an important determinant patient outcome. However, septic shock attributed Candida infection and its determinants outcome have not evaluated in a large population. Methods. A retrospective cohort study hospitalized patients with blood cultures positive for species was conducted at Barnes-Jewish Hospital, 1250-bed urban teaching hospital (January 2002–December 2010). Results. Two hundred twenty-four consecutive...