Luca Brazzi
A5002143975- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Hemodynamic Monitoring and Therapy
- Anesthesia and Pain Management
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Anesthesia and Sedative Agents
- Antibiotic Use and Resistance
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antibiotics Pharmacokinetics and Efficacy
- Renal function and acid-base balance
- Pneumonia and Respiratory Infections
- Nausea and vomiting management
- Antibiotic Resistance in Bacteria
- Organ Transplantation Techniques and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University of Turin
2016-2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2016-2025
Fondazione Ricerca Molinette
2017-2024
University of Novi Sad
2024
Sapienza University of Rome
2024
European University
2024
University of Southern Denmark
2024
Alexandra Hospital
2024
Ludwig-Maximilians-Universität München
2023
Charité - Universitätsmedizin Berlin
2023
Hemodynamic therapy to raise the cardiac index and oxygen delivery supranormal levels may improve outcomes in critically ill patients. We studied whether increasing a level (cardiac-index group) or mixed venous saturation normal (oxygen-saturation would decrease morbidity mortality among patients, as compared with control group which target was index.
Although placing patients with acute respiratory failure in a prone (face down) position improves their oxygenation 60 to 70 percent of the time, effect on survival is not known.
<h3>Importance</h3> Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about types of infections, causative pathogens, and outcomes can aid development policies for prevention, diagnosis, treatment, resource allocation may assist design interventional studies. <h3>Objective</h3> To provide prevalence infection available resources ICUs worldwide. <h3>Design, Setting, Participants</h3> Observational 24-hour point study with longitudinal follow-up at...
<h3>Importance</h3> Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information available on adverse peri-intubation events. <h3>Objective</h3> To evaluate incidence nature events to assess current practice <h3>Design, Setting, Participants</h3> The International Observational Study Understand Impact Best Practices Airway Management Critically Ill Patients (INTUBE) study was an international, multicenter, prospective...
Acute left ventricular dysfunction is a major complication of cardiac surgery and associated with increased mortality. Meta-analyses small trials suggest that levosimendan may result in higher rate survival among patients undergoing surgery.
Volatile (inhaled) anesthetic agents have cardioprotective effects, which might improve clinical outcomes in patients undergoing coronary-artery bypass grafting (CABG).We conducted a pragmatic, multicenter, single-blind, controlled trial at 36 centers 13 countries. Patients scheduled to undergo elective CABG were randomly assigned an intraoperative regimen that included volatile (desflurane, isoflurane, or sevoflurane) total intravenous anesthesia. The primary outcome was death from any...
BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized patients. Little is known about patients who likely to experience opioid-induced respiratory depression on the general care floor and may benefit from improved monitoring early intervention. The trial objective was derive validate risk prediction tool for receiving opioids, as detected by continuous pulse oximetry capnography monitoring. METHODS: PRediction of Opioid-induced Depression In monitored capnoGraphY...
Meropenem is a widely prescribed β-lactam antibiotic. exhibits maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant drug levels above the minimal inhibitory concentration. Compared with intermittent administration, administration of meropenem may improve clinical outcomes.To determine whether reduces composite mortality and emergence pandrug-resistant or extensively drug-resistant bacteria compared in critically ill patients sepsis.A double-blind, randomized...
Climate change is a defining issue for our generation. The carbon footprint of clinical practice accounts 4.7% European greenhouse gas emissions, with the Union ranking as third largest contributor to global healthcare industry's footprint, after United States and China. Recognising importance urgent action, Society Anaesthesiology Intensive Care (ESAIC) adopted Glasgow Declaration on Environmental Sustainability in June 2023. Building this initiative, ESAIC Committee now presents consensus...
Rationale: Prone positioning reduces mortality in patients with severe acute respiratory distress syndrome (ARDS). To date, no evidence supports the use of prone (PP) during venovenous extracorporeal oxygenation (ECMO).Objectives: The aim study was to assess feasibility, safety, and effect on lung mechanics PP ECMO. As a secondary exploratory aim, we assessed association between hospital mortality.Methods: We performed multicenter retrospective cohort six Italian ECMO centers, including...
Definitive guidelines for anticoagulation management during veno-venous extracorporeal membrane oxygenation (VV ECMO) are lacking, whereas bleeding complications continue to pose major challenges.
Here we report on seven intensive care unit (ICU) patients with coronavirus disease 2019 (COVID-19)-related acute respiratory distress syndrome (ARDS) who developed positive rectal swabs and invasive infections due to carbapenemase-producing Klebsiella pneumoniae (CP-Kp). Notwithstanding the infection prevention measures introduced during COVID-19 pandemic changes in hospitalised population, attention CP-Kp must remain high, especially critically ill setting.
Objective To test the effectiveness of mid-regional pro-adrenomedullin (MR-proADM) in comparison to C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate dehydrogenase (LDH) predicting mortality COVID-19-ICU-patients. Methods All consecutive COVID-19 adult patients admitted between March and June 2020 ICU a referral, university hospital Northern-Italy were enrolled. MR-proADM routine laboratory measured within 48 hours from admission, on day 3, 7 14. Survival curves difference with...
Abstract Background Extracorporeal membrane oxygenation (ECMO) has become an established rescue therapy for severe acute respiratory distress syndrome (ARDS) in several etiologies including influenza A H1N1 pneumonia. The benefit of receiving ECMO coronavirus disease 2019 (COVID-19) is still uncertain. aim this analysis was to compare the outcome patients who received veno-venous COVID-19 and Influenza associated ARDS. Methods This a multicenter retrospective cohort study adults with ARDS,...
Since the beginning of COVID-19 pandemic, impact superinfections in intensive care units (ICUs) has progressively increased, especially carbapenem-resistant Acinetobacter baumannii (CR-Ab). This observational, multicenter, retrospective study was designed to investigate characteristics ICU patients developing CR-Ab colonization/infection during an stay and evaluate mortality risk factors a regional network. A total 913 were admitted participating ICUs; 19% became positive for CR-Ab, either...