Antonia Koutsoukou
A5028120366- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Airway Management and Intubation Techniques
- Nosocomial Infections in ICU
- Asthma and respiratory diseases
- Antibiotic Resistance in Bacteria
- Blood disorders and treatments
- Cardiovascular and exercise physiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Neuroscience of respiration and sleep
- Inhalation and Respiratory Drug Delivery
- Obstructive Sleep Apnea Research
- Venous Thromboembolism Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Antifungal resistance and susceptibility
- Tracheal and airway disorders
Sotiria General Hospital
2015-2024
National and Kapodistrian University of Athens
2015-2024
Tripoli Central Hospital
2022
Laiko General Hospital of Athens
2022
Chest Diseases Hospital
2021
Intensive Care Society
2019
Creative Research Enterprises (United States)
2019
University of Milan
2019
Massachusetts General Hospital
2019
Evangelismos Hospital
2000-2015
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild respiratory tract infection, severe cases with acute distress syndrome, failure, and death. Reports on a dysregulated immune system in call for better characterization understanding changes system. Methods In order dissect COVID-19-driven host responses, we performed RNA-seq whole blood cell transcriptomes...
The state of immune activation may guide targeted immunotherapy in sepsis. In a double-blind, double-dummy randomized clinical study, 240 patients with sepsis due to lung infection, bacteremia, or acute cholangitis were subjected measurements serum ferritin and HLA-DR/CD14. Patients macrophage activation-like syndrome (MALS) immunoparalysis treatment anakinra recombinant interferon-gamma placebo. Twenty-eight-day mortality was the primary endpoint; classification secondary endpoint. Using...
Colistin has been revived, in the era of extensively drug-resistant (XDR) Gram-negative infections, as last-resort treatment critically ill patients. Recent studies focusing on optimal dosing strategy colistin have demonstrated necessity a loading dose at initiation (D. Plachouras, M. Karvanen, L. E. Friberg, Papadomichelakis, A. Antoniadou, I. Tsangaris, Karaiskos, G. Poulakou, F. Kontopidou, Armaganidis, O. Cars, and H. Giamarellou, Antimicrob Agents Chemother 53:3430-3436, 2009,...
Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared patients other populations. The main objective of our was to determine patients.Planned ancillary analysis a multicenter retrospective European cohort. diagnosed using clinical, radiological quantitative microbiological criteria. Univariable multivariable marginal Cox's regression models,...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
It has been suggested that in patients with adult respiratory distress syndrome (ARDS), intrinsic positive end-expiratory pressure (PEEPi) is generated by a disproportionate increase expiratory flow resistance. Using the negative (NEP) technique, we assessed whether limitation (EFL) and PEEPi were present at zero PEEP 10 semirecumbent, mechanically ventilated ARDS patients. Because bronchodilators may decrease airway resistance, also investigated effect of nebulized salbutamol on EFL, PEEPi,...
During the current pandemic, we witnessed a rise of post-intubation tracheal stenosis (PITS) in patients intubated due to COVID-19. We prospectively analyzed data from referred our institution during last 18 months for severe symptomatic upper airway complications. Interdisciplinary bronchoscopic and/or surgical management was offered. Twenty-three with PITS tracheoesophageal fistulae were included. They had undergone 31.85 (±22.7) days ICU hospitalization and 17.35 (±7.4) intubation....
Abstract Background Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site infection in interstitial space fluid crucial clinical outcomes. Current assessment methods, such as epithelial lining and tissue homogenates, have limitations providing longitudinal pharmacokinetic data. Main body Lung microdialysis, an invasive research technique predominantly...
In this study the authors investigated whether expiratory flow limitation (FL) is present during tidal breathing in patients with bilateral bronchiectasis (BB) and it related to severity of chronic dyspnoea (Medical Research Council (MRC) scale), exercise capacity (maximal mechanical power output ( WR max )) disease, as assessed by high-resolution computed tomography (HRCT) scoring. Lung function, MRC dyspnoea, HRCT score, FL were 23 stable caucasian (six males) aged 56±17 yrs. was at rest...
Objective To assess the effects of different positive end-expiratory pressure (PEEP) levels (0, 5, 10, and 15 cm H2O) on tidal expiratory flow limitation (FL), regional intrinsic (PEEPi) inhomogeneity, alveolar recruited volume (Vrec), respiratory mechanics, arterial blood gases in mechanically ventilated patients with acute distress syndrome (ARDS). Design Prospective clinical study. Setting Multidisciplinary intensive care unit a university hospital. Patients Thirteen sedated, during first...
It is known that, in stable asthmatics at rest, tidal expiratory flow limitation (EFL) and dynamic hyperinflation (DH) are seldom present. This study investigated whether develop EFL DH during exercise with concurrent of maximal work rate (WR max ). A total 20 a condition aged 32±13 yrs (mean± sd ) forced volume one second (FEV 1 101±21% the predicted value were studied. Only three patients exhibited an FEV below normal limits. On first visit, performed symptom-limited incremental (20 W·min...
The availability of antigen tests for SARS-CoV-2 represents a major step the mass surveillance incidence infection, especially regarding COVID-19 asymptomatic and/or early-stage patients. Recently, we reported development Bioelectric Recognition Assay-based biosensor able to detect S1 spike protein expressed on surface virus in just three minutes, with high sensitivity and selectivity. working principle was established by measuring change electric potential membrane-engineered mammalian...