A5044624867- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Insect Resistance and Genetics
- Radiomics and Machine Learning in Medical Imaging
- Endoplasmic Reticulum Stress and Disease
- Insect-Plant Interactions and Control
- Pancreatic and Hepatic Oncology Research
- Neurobiology and Insect Physiology Research
- Natural Compounds in Disease Treatment
- Cancer-related molecular mechanisms research
- Gallbladder and Bile Duct Disorders
- Mosquito-borne diseases and control
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tea Polyphenols and Effects
- Esophageal and GI Pathology
- Autophagy in Disease and Therapy
- Advanced Neuroimaging Techniques and Applications
- Insect and Pesticide Research
- Natural product bioactivities and synthesis
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
Guiyang Medical University
2017-2025
Second Military Medical University
2022-2025
Wuhan University
2023-2025
Renmin Hospital of Wuhan University
2023-2025
China Three Gorges University
2025
Changhai Hospital
2022-2025
Shaanxi University of Chinese Medicine
2025
Xi'an Jiaotong University
2025
West China Hospital of Sichuan University
2022-2024
Sichuan University
2022-2024
Four cytochrome P450 cDNAs, CYP6AA7, CYP9J40, CYP9J34, and CYP9M10, were isolated from mosquitoes, Culex quinquefasciatus. The gene expression induction by permethrin compared for three different mosquito populations bearing resistance phenotypes, ranging susceptible (S-Lab), through intermediate (HAmCqG0, the field parental population) to highly resistant (HAmCqG8, 8th generation of selected offspring HAmCqG0). A strong correlation was found with levels following selection at larval stage...
Here we report a study of the 204 P450 genes in whole genome sequence larvae and adult Culex quinquefasciatus mosquitoes. The expression profiles were compared for susceptible (S-Lab) resistant mosquito populations, two different field populations mosquitoes (HAmCq MAmCq), parental G0 MAmCqG0) their permethrin selected offspring G8 MAmCqG6). While majority expressed at similar level between strains offspring, an up- or down-regulation feature gene was observed following selection. Compared...
Abstract Sexual communication in moths offers a simplified scenario to model and investigate insect sensory perception. Both PBPs (pheromone-binding proteins) PRs (pheromone receptors) are involved the detection of sex pheromones, but interplay between them still remains largely unknown. In this study, we have measured binding affinities four recombinant Chilo suppressalis (CsupPBPs) pheromone components analogs characterized six using Xenopus oocytes expression system. Interestingly, when...
Tea (Camellia sinensis) has long been consumed worldwide for its amazing flavor and aroma. Methyl jasmonate (MeJA), which acts as an effective elicitor among the plant kingdom, could mostly improve quality of tea aroma by promoting volatiles in leaves. Although a variety volatile secondary metabolites that contribute to have identified, our understanding biosynthetic pathways these compounds remained largely incomplete. Therefore, information aboaut transcriptome leaves and, specifically,...
Di-(2-ethylehxyl) phthalate (DEHP) is one of the most broadly representative phthalic acid esters (PAEs) used as a plasticizer in polyvinyl chloride (PVC) production, and considered to be an endocrine-disrupting chemical. DEHP its monoester metabolites are responsible for adverse effects on human health. An efficient DEHP-degrading bacterial strain Rhodococcus ruber YC-YT1, with super salt tolerance (0–12% NaCl), first DEHP-degrader isolated from marine plastic debris found coastal saline...
In last decade, there has been a concerted effort to reduce the potential threats of honeybees' population due exposure neonicotinoid pesticides. A new perspective was put forward ecological toxicity dinotefuran honeybee in terms an enantiomeric level study. Toxicity enantioselective, and S-dinotefuran 41.1- 128.4-fold more toxic than R-dinotefuran Apis mellifera (Apis Linnaeus), whereas exhibited comparative insecticidal activities (1.7–2.4 times) typical sucking pests Aphis gossypii...
Background Peritumoral hepatobiliary phase (HBP) hypointensity is an established prognostic imaging feature in hepatocellular carcinoma (HCC), often associated with microvascular invasion (MVI). Similar features are needed for non-HBP MRI. Purpose To propose a non-hepatobiliary-specific MRI tool similar value to peritumoral HBP hypointensity. Materials and Methods From December 2011 November 2021, consecutive patients HCC who underwent preoperative contrast-enhanced were retrospectively...
Umami amino acids inhibit the bitter and astringent taste presentation of catechins, which is essential for regulation green tea. In this study, concentration-intensity trends threshold properties major catechin monomers were investigated using an electronic tongue. The chemical structure interactions between ester-type catechins theanine, glutamic acid (Glu), aspartic (Asp) further analyzed by in vitro simulation analysis their reciprocal structures. results showed that bitterness...
Abstract Rhodopsin-like G protein-coupled receptors (GPCRs) are known to be involved in the GPCR signal transduction system and regulate many essential physiological processes organisms. This study, for first time, revealed that knockdown of rhodopsin-like gene resistant mosquitoes resulted a reduction mosquitoes’ resistance permethrin, simultaneously reducing expression two cAMP-dependent protein kinase A genes (PKAs) four related cytochrome P450 genes. The function was further confirmed...
Background: The production and maturation of interleukin (IL)-1β, regulated by the NF-κB NLRP3 signaling pathways, lie at core gout. This study aimed to evaluate antigout effect Cichorium intybus L. (also known as chicory) in vivo vitro. Methods: A gout animal model was established with monosodium urate (MSU) crystal injections. Rats were orally administered chicory extract or colchicine. Levels ankle edema, inflammatory activity, IL-1β release observed. Several essential targets pathways...
Abstract Insecticides, especially pyrethroids, are the most important in insect pest control and preventing vector-borne human diseases. However, pests, including mosquitoes, have developed resistance insecticides that used against them. Cytochrome P450s associated with insecticide through overexpression detoxification mechanisms species. In this study, we utilized a powerful tool, RNAi technique, to determine roles of key P450 genes overexpressed permethrin resistant mosquitoes confer...
Abstract Background Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site infection in interstitial space fluid crucial clinical outcomes. Current assessment methods, such as epithelial lining and tissue homogenates, have limitations providing longitudinal pharmacokinetic data. Main body Lung microdialysis, an invasive research technique predominantly...
The connection between peritoneal function and gut microbiota in fibrosis (PF) patients remains uncertain.
Background and aim: Proximal migration is one of the complications after pancreatic stenting. This study aims to determine incidence, risk factors endoscopic treatment proximally migrated stents. Methods: A retrospective search all retrograde cholangiopancreatography (ERCP) records was conducted from 1997 2022 in our tertiary center. stent defined as when shifted completely into duct distal end no longer visible at duodenal papilla. Results: total 9017 stentings 6083 patients were performed....
Endoplasmic reticulum (ER) stress-associated apoptosis is involved in various liver diseases, including fibrosis, nonalcoholic fatty disease, and cirrhosis. Hepatocytes respond to ER stress by eliciting unfolded protein response (UPR) enhancing autophagy. Autophagy a pivotal mechanism for sustaining normal function, through degradation of damaged fragments removal abnormal aggregates the lumen. Failure restore homeostasis via autophagy harmful hepatocytes contributes apoptosis. Recent...
This study aims to investigate the mechanism of action arsenic-based agents against hepatocellular carcinoma (HCC) and identify effective drug targets for HCC treatment. Huh7 HepG2 cells treated with NaAsO2 were assessed cell viability, pyroptosis, migration, invasion after undergoing lentiviral transfection. An orthotopic liver tumor model was established divided into a group treatment group. Proteins associated QRICH1, PRMT1, cGAS-STING, classical pyroptosis pathway quantified using...
BackgroundNasopharyngeal carcinoma (NPC) is a malignant head and neck cancer with high incidence in Southern China Southeast Asia. Patients remote metastasis recurrent NPC have poor prognosis. Thus, better understanding of pathogenesis may identify novel therapies to address the unmet clinical needs.MethodsH3K27ac ChIP-seq HiChIP was applied understand enhancer landscapes chromosome interactions. Whole genome sequencing conducted analyze relationship between genomic variations epigenetic...
Objective . This study was designed to evaluate the clinical efficacy of combined traditional Chinese medicine (TCM) and conventional chemotherapy versus in patients with stage II‐IIIA non‐small‐cell lung cancer (NSCLC) after radical surgery. Methods A retrospective cohort conducted NSCLC from Subei People′s Hospital Yangzhou Traditional Medicine City Jiangsu Province 2012 2016. Patients were divided into two groups: TCM user group (patients receiving treatment integrated chemotherapy)...