A5019969551- Hydrogels: synthesis, properties, applications
- Cellular Mechanics and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Microbial Inactivation Methods
- Polymer Nanocomposites and Properties
- Advanced Battery Technologies Research
- 3D Printing in Biomedical Research
- Advancements in Battery Materials
- Angiogenesis and VEGF in Cancer
- Advanced Battery Materials and Technologies
- Nerve injury and regeneration
- Smart Materials for Construction
- Hydraulic and Pneumatic Systems
- Advanced Materials and Mechanics
- Anodic Oxide Films and Nanostructures
- Tribology and Wear Analysis
- Magnetic and Electromagnetic Effects
- Meat and Animal Product Quality
- Polymer crystallization and properties
- Proteins in Food Systems
- Tissue Engineering and Regenerative Medicine
- Advanced Polymer Synthesis and Characterization
- Proteoglycans and glycosaminoglycans research
- Polydiacetylene-based materials and applications
Xi'an Jiaotong University
2015-2025
Guangdong Academy of Medical Sciences
2014-2025
Southern Medical University
2014-2025
Guangdong Provincial People's Hospital
2024-2025
Sun Yat-sen University
2024-2025
Marine Design & Research Institute of China
2024
First Hospital of Jilin University
2024
Jiangnan University
2008-2024
South China University of Technology
2023-2024
Akita Prefectural University
2021-2024
A novel biocompatible polysaccharide‐based self‐healing hydrogel, CEC‐l‐OSA‐l‐ADH hydrogel (“l” means “linked‐by”), is developed by exploiting the dynamic reaction of N ‐carboxyethyl chitosan (CEC) and adipic acid dihydrazide (ADH) with oxidized sodium alginate (OSA). The ability, as demonstrated rheological recovery, macroscopic observation, beam‐shaped strain compression measurement, attributed to coexistence imine acylhydrazone bonds in networks. shows excellent ability under...
Abstract The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and displays time‐dependent responses to deformation or loading, in terms of viscoelastic behaviors (e.g., stress relaxation creep). Viscoelasticity the ECM plays a critical role development, homeostasis, tissue regeneration, its implication disease progression has also been recognized recently. Hydrogels with tunable hold great promise recapitulate such mechanics found ECM, which have recently...
Abstract Atopic dermatitis (AD) is a chronic skin disease caused by immune dyshomeostasis and accompanied severe pruritus. Although oxidative stress mechanical scratching can aggravate AD inflammation, treatment targeting often overlooked, the efficiency of mechano-chemically synergistic therapy remains unclear. Here, we find that enhanced phosphorylation focal adhesion kinase (FAK) associated with scratch-exacerbated AD. We then develop multifunctional hydrogel dressing integrates...
Postoperative adhesions occur widely in various tissues, bringing the risk of secondary surgery and increased medical burden. Hydrogel barriers with Janus-adhesive ability can achieve physical isolation adjacent tissues are therefore considered an ideal solution. However, integrating endoscopic delivery convenience viscoelastic Janus hydrogel formation remains a great challenge. Here, we present report situ barrier using sprayable fast-Janus-gelation (FJG) powder. We first methacrylate...
A dextran‐based self‐healing hydrogel is prepared by reversible Diels–Alder reaction under physiological conditions. Cytocompatible fulvene‐modified dextran as main polymer chains and dichloromaleic‐acid‐modified poly(ethylene glycol) cross‐linkers are used. Both macro‐ microscopic observation well the rheological recovery test confirm property of dextran‐l‐poly(ethylene hydrogels (“l” means “linked‐by”). In addition, scanning electrochemical microscopy used to qualitatively quantitatively...
Abstract Self-healing injectable hydrogels can be formulated as three-dimensional carriers for the treatment of neurological diseases with desirable advantages, such avoiding potential risks cell loss during injection, protecting cells from shearing force injection. However, demands biocompatible self-healing to meet above requirements and promote differentiation neural stem (NSCs) into neurons remain a challenge. Herein, we developed polysaccharide-based hydrogel system novel carrier...
Hydrogel-based wearable epidermal sensors (HWESs) have attracted widespread attention in health monitoring, especially considering their colorimetric readout capability. However, it remains challenging for HWESs to work at extreme temperatures with long term stability due the existence of water. Herein, a transparent sensor thermal compatibility and smart multi-signals monitoring is developed, based on an anti-freezing anti-drying hydrogel high transparency (over 90% transmittance),...
Brain lesions can arise from traumatic brain injury, infection, and craniotomy. Although injectable hydrogels show promise for promoting healing of health surrounding tissue, enabling cellular ingrowth restoring neural tissue continue to be challenging. It is hypothesized that these challenges in part the mismatch composition, stiffness, viscoelasticity between hydrogel parenchyma, this hypothesis tested by developing evaluating a self-healing not only mimics but also stiffness native...
The endothelial cell (EC) outgrowth in both vasculogenesis and angiogenesis starts with remodeling surrounding matrix proceeds the crosstalk between cells for multicellular vasculature formation. mechanical plasticity of matrix, defined as ability to permanently deform by external traction, is pivotal modulating behaviors. Nevertheless, implications on cell-to-cell interactions during EC outgrowth, along molecular pathways involved, remain elusive. Here we develop a collagen-hyaluronic acid...
Owing to the shape-dependent catalytic activity of Fe3O4 nanoparticles, controlling their morphology is great significance. In this work, we propose a simple, nontoxic, water-based strategy for fabrication magnetic nanoparticle/hydrogel nanocomposites in which highly crystalline nanooctahedra can be fabricated situ within negatively charged hydrogel matrix. The nanocrystals easily tuned by adjusting crosslinking concentration hydrogel. Furthermore, activities were studied, and nanocomposite...