A5101911337- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Advanced Photocatalysis Techniques
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- MXene and MAX Phase Materials
- Luminescence Properties of Advanced Materials
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- Graphene and Nanomaterials Applications
- Materials Engineering and Processing
- Carbon and Quantum Dots Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Photodynamic Therapy Research Studies
- Covalent Organic Framework Applications
- Water Quality and Pollution Assessment
- Atherosclerosis and Cardiovascular Diseases
Gansu Provincial Hospital
2025
Harbin Normal University
2025
Guangzhou Medical University
2025
University of Hong Kong
2024-2025
State Key Laboratory of Biotherapy
2024
Sichuan University
2024
Yinchuan First People's Hospital
2024
Chinese Research Academy of Environmental Sciences
2022-2024
Southwest Minzu University
2023
Beijing University of Chemical Technology
2019-2023
Abstract Although two-dimensional (2D) layered double hydroxides (LDHs) have been widely used as efficient nanoagents for biological diagnosis and treatment, they found to be inert photosensitizers (PSs) photodynamic therapy (PDT). Herein, we report the defect engineering of ultrathin 2D CoMo-LDH NiMo-LDH nanosheets highly active inorganic PSs PDT in third near-infrared (NIR-III) window. Hydrothermal-synthesized are etched via a simple acid treatment obtain defect-rich nanosheets....
Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel...
Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as TME-responsive platform NIR-II The CoCuMo-LDH loaded on LA can be transformed from crystalline into amorphous...
Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from...
2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.
Abstract Although metal single‐atom (SA)‐based nanomaterials are explored as sonosensitizers for sonodynamic therapy (SDT), they normally exhibit poor activities and need to combine with other therapeutic strategies. Herein, the deposition of SAs on oxygen vacancy (OV)‐rich WO 3− x nanosheets generate a synergistic effect efficient SDT is reported. Crystalline 3 OV‐rich first prepared by simple calcination ·H 2 O under an air N atmosphere, respectively. Pt, Cu, Fe, Co, Ni then deposited...
Abstract Although CeO 2 nanomaterials have been widely explored as nanozymes for catalytic therapy, they still suffer from relatively low activities. Herein, the catalyzing generation and stabilization of oxygen vacancies on nanorods by Pt nanoclusters via H gas reduction under mild temperature (350 °C) to obtain Pt/CeO 2− x , which can serve a highly efficient nanozyme cancer is reported. The deposited atomic layer deposition technique not only catalyst generate through hydrogen spillover...
Poly(methyl methacrylate) (PMMA) bone cement has been widely used in orthopedic surgeries including total hip/knee replacement, vertebral compression fracture treatment, and defect filling. However, aseptic loosening of the interface between PMMA often leads to failure. Hence, development modified that facilitates growth into is key reducing incidence loosening. In this study, MgAl-layered double hydroxide (LDH) microsheets (PMMA&LDH) with superior osseointegration performance synthesized....
Although artificial bone repair scaffolds, such as titanium alloy, bioactive glass, and hydroxyapatite (HAp), have been widely used for treatment of large-size defects or serious destruction, they normally exhibit unsatisfied efficiency because their weak osteogenic angiogenesis performance well poor cell crawling adhesion properties. Herein, the surface functionalization MgAlEu-layered double hydroxide (MAE-LDH) nanosheets on porous HAp scaffolds is reported a simple effective strategy to...
Abstract Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range promising applications. However, the synthesis 2D superlattice nanosheets remains big challenge. Herein, preparation polyaniline/MoO 3− x (PANI/MoO ) via intercalation‐induced morphological transformation from MoO 3 nanobelts, as efficient Fenton‐like reagents chemodynamic therapy (CDT), reported. Micrometer‐long nanobelts are co‐intercalated with Na...
Over the last decades, bone tissue engineering has increasingly become a research focus in field of biomedical engineering, which biomaterials play an important role because they can provide both biomechanical support and osteogenic microenvironment process regeneration. Among these biomaterials, two-dimensional (2D) nanomaterials have recently attracted considerable interest owing to their fantastic physicochemical biological properties including great biocompatibility, excellent...
Despite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe-LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) further modification on bioactive glass scaffold (BGS) obtain versatile platform (BGS@LDH/Se) for comprehensive osteosarcoma management. The uniform dispersion negatively charged SeNPs LDH surface...
Abstract Sonodynamic therapy (SDT) is demonstrated to trigger the systemic immune response of organism and facilitate treatment metastatic tumors. However, SDT‐mediated neutrophil extracellular traps (NETs) formation can promote tumor cell spread, thus weakening therapeutic effectiveness Herein, amorphous CoW‐layered double hydroxide (a‐CoW‐LDH) nanosheets are functionalized with a peptidyl arginine deiminase 4 (PAD4) inhibitor, i.e., YW3‐56, construct multifunctional nanoagent (a‐LDH@356)...
Abstract Strategies of manipulating redox signaling molecules to inhibit or activate immune signals have revolutionized therapeutics involving reactive oxygen species (ROS). However, certain diseases with dual resistance barriers the attacks by both ROS and cells, such as bacterial biofilm infections medical implants, are difficult eradicate a single exogenous oxidative stimulus due diversity complexity involved. Here, this work demonstrates that metal‐organic framework (MOF) nanoparticles...