A5006892981- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- COVID-19 Clinical Research Studies
- Bone Tissue Engineering Materials
- Pancreatic and Hepatic Oncology Research
- SARS-CoV-2 and COVID-19 Research
- Bone Metabolism and Diseases
- Long-Term Effects of COVID-19
- Hip and Femur Fractures
- Nutrition and Health in Aging
- RNA modifications and cancer
- Orthopedic Infections and Treatments
- Magnesium Alloys: Properties and Applications
- Gastric Cancer Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Sarcoma Diagnosis and Treatment
- Knee injuries and reconstruction techniques
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
- Surface Treatment and Residual Stress
- Cancer Genomics and Diagnostics
- Enhanced Recovery After Surgery
- Reproductive Biology and Fertility
- Bone fractures and treatments
- Neuroendocrine Tumor Research Advances
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2017-2025
Wenzhou Medical University
2016-2025
Shanghai Sixth People's Hospital
2008-2024
Lishui City People's Hospital
2012-2024
First Affiliated Hospital of Wenzhou Medical University
2023
Shanghai Jiao Tong University
2008-2022
Kunsan National University
2021-2022
University of Kansas Medical Center
2020
Second Military Medical University
2014-2019
Changhai Hospital
2014-2016
Operation time of implantable electronic devices is largely constrained by the lifetime batteries, which have to be replaced periodically surgical procedures once exhausted, causing physical and mental suffering patients increasing healthcare costs. Besides efficient scavenging mechanical energy internal organs, this study proposes a self-powered, flexible, one-stop triboelectric active sensor (iTEAS) that can provide continuous monitoring multiple physiological pathological signs. As...
Aim: To analyze the m6A methylome of osteosarcoma stem cells (OSCs). Materials & methods: Chemoresistant OSCs were enriched by doxorubicin treatment. Expression m6A-related enzymes was detected quantitative real-time-PCR and western blot. MeRIP-seq RNA-seq performed to identify differences in methylation gene expression. Data analysis conducted explore modified genes their clinical significance. Results: Three altered OSCs. Differentially methylated some pathways regulating pluripotency...
Hydrogen has been used to suppress tumor growth with considerable efficacy. Inhalation of hydrogen gas and oral ingestion hydrogen-rich saline are two common systemic routes administration. We have developed a topical delivery method at targeted sites through the degradation magnesium-based biomaterials. However, underlying mechanism hydrogen's role in cancer treatment remains ambiguous. Here, we investigate cell apoptosis triggered by released from find that localized release increases...
Modic changes are the MRI signal of degenerative lumbar vertebral endplate and which lead to or accelerate intervertebral disc degeneration. NLRP3, caspase-1, interleukin-1β (IL-1β) play a pivotal role in pathogenesis many inflammatory diseases, such as osteoarthritis. However, roles IL-1β its activators caspase-1 NLRP3 unclear endplate.We asked: (1) What histologic features chondrogenic markers' gene expressions between cartilaginous endplates patients with trauma (control)? (2) How does...
Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer‐related causes death. Deregulation or dysfunction miRNAs contribute to cancer development. In this study, we found that low miR‐545 level and high RIG‐I protein in PDAC tissues were both correlated with survival rate. MiR‐545 up‐regulation inhibited cell lines growth vice versa. 3′UTR was targeted by miR‐545. Thus concluded levels promote tumor cells growth, is associated reduced patients. exerts its effects directly...
Background and purpose Postoperative C-reactive protein (CRP) levels in serum appear to reflect surgical trauma. We examined CRP after 4 types of arthroplasty.Material methods investigated 102 patients who had total knee arthroplasty (TKA), computer navigation-assisted (NAV-TKA), hip resurfacing (metal on metal, MMSA) (THA), respectively. were estimated before surgery postoperatively at 2 7 days.Results Postoperatively, the peak highest second day each groups. The CPR lower than those...
Abstract Objective Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for evaluation coronavirus-infected patients, guide diagnosis and treatment this disease areas provide a reference prevention control situation. Methods The data 33 respiratory symptoms caused by Wenzhou city from January 15 February 12, 2020, were thoroughly reviewed. At onset disease, found that primary fever, cough,...
Abstract This study investigated the surface characteristics and in vitro cytocompatibility of hierarchical textured titanium surfaces with nanograins microroughness, produced by mechanical attrition treatment (SMAT). The were evaluated scanning electron microscopy, X‐ray diffraction, transmission contact angle, energy measurements. SMAT processed (hereafter Ti‐SMAT surfaces) assessed terms cellular attachment, morphology, viability, alkaline phosphatase (ALP) activity, mRNA gene expression....
Context: Naringenin and tofacitinib are often used together for treatment of rheumatoid arthritis in Chinese clinics.Objective: This experiment investigates the effect naringenin on pharmacokinetics rats.Materials methods: Twelve Sprague-Dawley rats were randomly divided into two groups (experimental group control group). The experimental was pre-treated with (150 mg/kg/day) weeks before dosing tofacitinib, equal amounts CMC-Na solution group. After a single oral administration 5 mg/kg 50 μL...
Multidrug resistance (MDR) against chemotherapeutic agents has become the major obstacle to successful cancer therapy and multidrug resistance-associated proteins (MRPs) mediated drug efflux is key factor for MDR. Indomethacin (IND), one of non-steroidal anti-inflammatory agents, been demonstrated increase cytotoxic effects anti-tumor as MRP substrates. In this study, dextran-g-indomethacin (DEX-IND) polymeric micelles were designed delivery paclitaxel (PTX) treatment MDR tumors. The DEX-IND...
Thrombosis and coagulopathy are pervasive pathological features of coronavirus disease 2019 (COVID-19), thrombotic complications a sign severe COVID-19 associated with multiple organ failure increased mortality. Platelets essential cells that regulate hemostasis, thrombus formation inflammation; however, the mechanism underlying interaction between platelets acute respiratory syndrome 2 (SARS-CoV-2) remains unclear. The present study performed RNA sequencing on isolated from obtained 10...
Abstract Objective: Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas, we aimed to identify potential biomarkers for evaluation coronavirus-infected patients, guide diagnosis and treatment this disease areas provide a reference prevention control situation.Methods: The data 33 respiratory symptoms caused by Wenzhou city from January 15 February 12, 2020, were thoroughly reviewed. At onset disease, found that primary fever, cough,...