A5100352876- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Pediatric health and respiratory diseases
- Sinusitis and nasal conditions
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Allergic Rhinitis and Sensitization
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Cytomegalovirus and herpesvirus research
- Ear and Head Tumors
- RNA modifications and cancer
- Animal Virus Infections Studies
- Galectins and Cancer Biology
- Histone Deacetylase Inhibitors Research
- Bioactive natural compounds
- Oral health in cancer treatment
- Dental Trauma and Treatments
Institute of Hematology & Blood Diseases Hospital
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Shandong First Medical University
2023
Shandong Provincial Hospital
2023
Xuzhou Medical College
2023
Nanfang Hospital
2004-2022
Southern Medical University
2004-2022
Shaoxing People's Hospital
2020
University of Arkansas for Medical Sciences
2020
Daqing Oilfield General Hospital
2020
Aortic dissection (AD) presents a medical challenge for clinicians. Here, to determine the role of novel small non-coding piRNA-823 (piR-823) in AD, murine and human aorta from patients with AD were used. A high expression levels piR-823 found AD. Using performed loss- gain-of-function assays vitro vivo, we explore regulatory effect on vascular smooth muscle cells (VSMCs) obviously facilitates proliferation, migration, phenotypic transformation VSMCs or without nicotine treatment. directly...
MicroRNAs (miRNAs) are a class of single-stranded, non-coding RNAs about 22 nucleotides in length. Increasing evidence implicates miRNAs may function as oncogenes or tumor suppressors. Here we showed that miR-107 directly targeted MCL1 and activated ATR/Chk1 pathway to inhibit proliferation, migration invasiveness cervical cancer cells. Moreover, found was frequently up-regulated cancer, knockdown markedly inhibited cell invasion, whereas ectopic expression significantly enhances these...
Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer‐related causes death. Deregulation or dysfunction miRNAs contribute to cancer development. In this study, we found that low miR‐545 level and high RIG‐I protein in PDAC tissues were both correlated with survival rate. MiR‐545 up‐regulation inhibited cell lines growth vice versa. 3′UTR was targeted by miR‐545. Thus concluded levels promote tumor cells growth, is associated reduced patients. exerts its effects directly...
The level of Epstein-Barr virus DNA (EBV-DNA) in the plasma prior and subsequent to treatment is a reliable biomarker for screening, diagnosis, monitoring prognosis nasopharyngeal carcinoma (NPC). present retrospective study aimed determine whether pre‑ post‑treatment levels EBV‑DNA were predictive survival large sample patients with NPC. 637 NPC was determined by quantitative polymerase chain reaction. value predicting then analyzed. results revealed that pre‑treatment loads significantly...
Abstract Osteosarcoma (OS) is one of the most frequent malignant bone tumor types. Traditional treatments OS involve standard chemotherapy or combination with radiation before and after surgery. Cisplatin effective chemotherapeutic drugs used for treating osteosarcoma. However, patients advanced stages develop cisplatin resistance, leading to a major clinical challenge. In this study, we investigated roles miR‐329‐3p in sensitivity osteosarcoma cells. We found was significantly downregulated...
Neo-osteogenesis of the paranasal sinuses is a radiologic finding unclear clinical significance. Although current evidence suggests that these bony changes represent an inflammatory response rather than infectious osteitis, bacteria associated with sinonasal mucosa may induce mediators as mechanism neo-osteogenesis. The objectives this study were (1) to determine whether there association between isolated on sinus culture and neo-osteogenesis, (2) identify other predictive factors for...
Objectives: To assess the relationships between CD163 expression, localization of CD163+ macrophages, clinicopathological features and prognosis NPC.Methods: A total 110 cases NPC specimens 80 nasopharyngitis were analysed for expression by immunohistochemistry EBERs in situ hybridization.Results: + macrophages tumour stroma positively correlated with nodal stage. Higher Epstein–Barr virus-encoded RNAs (EBERs) nuclei cells was associated higher density stroma. More importantly, greater...
Objective this study aimed to investigate the expression and clinical significance of miR-21 miR-210 in serum patients with colorectal cancer (CRC). Methods levels 40 CRC (CRC group) 20 healthy (control were measured by qRT-PCR. Correlation analysis was performed relationship between characteristics, including gender, age, tumor location, size, stage, local invasion TNM staging. The group separately before after surgery. ROC evaluate diagnostic value miR-210. Results much higher than those...
Glycine is known to protect against neuronal death. However, the underlying mechanism remains be elucidated. The microRNA-301a involved in both biological and pathological processes. But it not whether has a neuroprotective property. In this study, we aimed determine glycine-induced neuroprotection requires microRNA-301a-dependent signaling.We provided first evidence that glycine increased expression of cultured rat cortical neurons protected death through up-regulation after oxygen-glucose...
Nasopharyngeal carcinoma (NPC) causes severe oncogenic lesions in the nasopharynx. CD47, a transmembrane integrin-associated protein, plays key role ability of tumor cells to escape phagocytosis, working as an immune checkpoint response. Besides this role, CD47 has been reported regulate cell proliferation and migration. The present study addresses relationship between microRNA-200a examines their regulatory mechanisms NPC. Bioinformatics analyses dual-luciferase reporter assays were used...
TIMP-2 gene plays an important role in the development of breast cancer. The present study was conducted to evaluate whether polymorphisms are associated with cancer risk a Han Chinese cohort.Six single nucleotide (SNPs) within 571 and 578 healthy control subjects were genotyped through Agena MassARRAY. Logistic regression analysis used assess influence on Functional annotation variants expression analyzed by bioinformatics.Bioinformatics found that rs4789936 likely affect transcription...
To investigate the effects of desmoglein 3 (DSG3) gene mediating epidermal growth factor/epidermal factor receptor (EGF/EGFR) signaling pathway on inflammatory response and immune function anaphylactic rhinitis (AR). Ten seventy male BALB/c mice were randomly selected as normal control group, remaining 60 used to construct AR model. model divided into 6 groups: group (instilled with 5 μL saline), empty vector liposome mixture), siRNA-DSG3 carrier AG1478 EGF/EGFR inhibitor AG1478),...
// Liang Wang 1, * , Gang Li Nan Liu 2, Zhen 2 Xiaoshan Xu Jing Qi Dongni Ren Pengxing Zhang Yongsheng 3 Yanyang Tu 1 Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China Experimental Surgery, Administrative, These authors have contributed equally to this work Correspondence to: Tu, email: tu.fmmu@gmail.com Zhang, zhangys_td@163.com Keywords: SOX9, gliomas, polymorphism, genetic susceptibility Received: June 17,...
Lack of adequate objectivity and universality, available models are still difficult to be applied clinical practice in predicting occult cervical metastasis early oral squamous cell carcinoma (OSCC). Taking abnormal metabolic state into consideration, the current model is helpful distinguish those patients with or without metastasis.This study retrospectively analyzed 330 OSCC initially diagnosed cT1-2N0M0 stage received neck dissection from January 2020 July 2022. The was identified by...
Objective We aimed to develop a nomogram predict cancer-specific survival (CSS) in patients with hypopharyngeal squamous cell carcinoma (HSCC) treated primary surgery provide more accurate risk stratification for patients. Methods retrospectively collected data of 1144 eligible HSCC from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 2015. Patients were randomly divided into training validation groups (ratio 6:4) we used univariate multivariate Cox analysis....