A5100532591- Head and Neck Cancer Studies
- Virus-based gene therapy research
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Dental Radiography and Imaging
- Dental Implant Techniques and Outcomes
- Cancer Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Psoriasis: Treatment and Pathogenesis
- Ubiquitin and proteasome pathways
- Collaboration in agile enterprises
- Machine Learning in Healthcare
- Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Lysosomal Storage Disorders Research
- Advanced Scientific and Engineering Studies
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Endodontics and Root Canal Treatments
- Gastroesophageal reflux and treatments
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
First Affiliated Hospital of Xiamen University
2025
Beijing Center for Disease Prevention and Control
2024
Dalian Medical University
2024
Yangzhou University
2024
Chinese PLA General Hospital
2023
Center for Disease Control
2023
Novartis (United States)
2021
Southern Medical University
2015-2019
Nanfang Hospital
2015-2019
Chongqing Medical University
2008-2012
ABSTRACT Objective: To compare the diagnostic accuracy between cone-beam computed tomography (CBCT) and periapical radiography for detecting simulated external apical root resorption (EARR) in vitro. Materials Methods: The study sample consisted of 160 single-rooted premolar teeth simulating EARR varying degrees according to four setups: no (intact teeth), mild (cavity 1.0 mm diameter depth on surface), moderate (0.4 mm, 0.8 1.2 1.6 shortening), severe (2.4 2.8 3.2 3.6 shortening). Two...
Abstract Keratinocyte proliferation and differentiation in epidermis are well-controlled essential for reacting to stimuli such as ultraviolet light. Imbalance between is a characteristic feature of major human skin diseases psoriasis squamous cell carcinoma. However, the effect keratinocyte metabolism on remains largely elusive. We show here that gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) promotes while inhibits suppresses development. FBP1 identified among most upregulated...
Background Sepsis complicates acute pancreatitis (AP), increasing mortality risk. Few studies have examined how sepsis and its onset timing affect in AP. This study evaluates the association between occurrence all-cause AP, focusing specifically on impact of timing. Methods multicenter retrospective cohort included 494 ICU-admitted AP patients from MIMIC-IV database 91 our center. Patients were grouped by Clinical outcomes in-hospital 90-day mortality. Machine learning identified key...
Abstract The formation of foam cells triggered by excessive lipid accumulation within macrophages is a hallmark atherosclerosis development. Scavenger receptor‐A (SR‐A) key regulator uptake during oxidized low‐density lipoprotein (oxLDL)‐induced cell formation. Ubiquitination crucial post‐translational modification that regulates the stability and function targeted proteins, but whether SR‐A ubiquitinated how ubiquitination affects unknown. We found ovarian tumor domain protease 1 (OTUB1),...
Objectives: To assess the relationships between CD163 expression, localization of CD163+ macrophages, clinicopathological features and prognosis NPC.Methods: A total 110 cases NPC specimens 80 nasopharyngitis were analysed for expression by immunohistochemistry EBERs in situ hybridization.Results: + macrophages tumour stroma positively correlated with nodal stage. Higher Epstein–Barr virus-encoded RNAs (EBERs) nuclei cells was associated higher density stroma. More importantly, greater...
OX40 (CD134), a member of the TNF receptor superfamily, is widely studied costimulatory immune checkpoint. Several agonistic antibodies are in clinical stage for cancer treatment, among which PF-04518600 leader and currently phase II trial. It has been recognized that one potential mode action anti-OX40 deletion intratumoral Tregs. Thus, novel human antibody, BAT6026, was generated with enhanced antibody dependent cellular cytotoxicity (ADCC) via fucose to strengthen its Treg depletion...
Laryngopharyngeal reflux (LPR) induces a differential damage effect on several anatomic sites within the larynx and hypopharynx; therefore, an in vitro model is needed for each site. This study aimed to establish primary culture method human laryngeal hypopharyngeal epithelial cells derived from multiple sites. Surgical mucosa specimens were treated with two-step enzymatic strategy culture. Of 46 samples, cultivation was achieved successfully 36 positive ratio 78.3%. In addition, flow...
Objective To explore the role of CXCR4/SDF-lα axis in organ-specific metastasis nasopharyngeal carcinoma （NPC） by assessment CXCR4 expression NPC cells and SDF-lα distant target organs NPC. Methods Thirty patients with fifteen normal subjects were recruited this study. The expressions cases identified RT-PCR immunohistochemistry （IHC）, then relationship between clinicopathological factors was analyzed. IHC also used to analyze protein cervical lymph nodes （including superior inferior deep ）,...
In locally advanced esophageal cancer, the controversy over two traditional treatment modalities, neoadjuvant radiotherapy and chemotherapy, has been unending also challenged by addition of immunotherapy. Neoadjuvant immunotherapy led to an increasing diversity combination among which immunochemotherapy emerged, with current clinical studies initially demonstrating its efficacy safety. We report a case patient cancer who underwent cycles successful surgery achieved pathological complete...
Aim at the risk control problems of airline strategic alliances in process forming, operating and managing, objectives management alliance was proposed. And early-warning system constructed. Then measure avoiding disassembling put forward. This will provide decision support for airlines to risks alliance.
<title>Abstract</title> Keratinocyte proliferation and differentiation in epidermis are well controlled essential for reacting to stimuli such as ultraviolet light. Imbalance between is a characteristic feature of major human skin diseases psoriasis squamous cell carcinoma. However, the effect keratinocyte metabolism on remains largely elusive. We show here that gluconeogenic enzyme fructose 1, 6-bisphosphatase 1 (FBP1) promotes while inhibits suppresses development. FBP1 identified among...