A5056470075- Cancer-related molecular mechanisms research
- Sleep and related disorders
- Pancreatic function and diabetes
- Heavy Metal Exposure and Toxicity
- Bone Tissue Engineering Materials
- Spine and Intervertebral Disc Pathology
- Acupuncture Treatment Research Studies
- Gastroesophageal reflux and treatments
- Birth, Development, and Health
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Dysphagia Assessment and Management
- Trace Elements in Health
- Folate and B Vitamins Research
- Orthopaedic implants and arthroplasty
- Infectious Diseases and Tuberculosis
- Spinal Fractures and Fixation Techniques
- Cardiovascular Health and Risk Factors
- Mitochondrial Function and Pathology
- Ginseng Biological Effects and Applications
- Telomeres, Telomerase, and Senescence
- Bone and Dental Protein Studies
- Sexual function and dysfunction studies
- Menopause: Health Impacts and Treatments
- Renin-Angiotensin System Studies
Huazhong University of Science and Technology
2019-2024
The First People's Hospital of Wenling
2017-2023
Wenzhou Medical University
2017-2023
Nanfang Hospital
2015-2022
Southern Medical University
2015-2022
Xi’an Children’s Hospital
2021-2022
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2020-2021
Genomics Institute of the Novartis Research Foundation
2015-2020
Macau University of Science and Technology
2018-2019
Chongqing Public Health Medical Center
2017-2018
Abstract Insufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made regulating insulin secretion from β-cells diabetic patients, no pharmacological agents have described that increase replication humans. Here we report aminopyrazine compounds stimulate robust proliferation adult primary islets, most likely as a result of combined inhibition DYRK1A and GSK3B. Aminopyrazine-treated human islets retain functionality vitro after...
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia diabetes. Thus, promoting proliferation could be one approach toward diabetes intervention. In this report we describe the discovery of potent selective DYRK1A inhibitor GNF2133, which was identified through optimization 6-azaindole screening hit. vitro, GNF2133 is able to proliferate both rodent human β-cells. vivo, demonstrated significant...
Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of pepsin, which shown to induce mucosal inflammation by damaging mucous membrane. Thus, pepsin linked an increased risk carcinoma, although potential mechanism remains largely unknown.The human cell lines Hep-2 Tu212 were exposed different concentrations morphology,...
Abstract Objective The aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way dose-dependent regulatory effect on osteoblast mineralization its molecular mechanism. Methods Initially, different concentrations ON were added osteoblasts, the gene bone sialoprotein (BSP), osteocalcin (OCN), osteopontin (OPN) alkaline phosphatase (ALP) detected using reverse‐transcription quantitative polymerase chain reaction (RT‐PCR)....
C-reactive protein (CRP) is a well-recognized biomarker of inflammation, which can be used as predictor cardiovascular disease. Evidence have suggested exposure to multiple metals/metalloids may affect immune system and give rise However, it lack study comprehensively evaluate the association metals CRP, interactions between metals, gene-metal interaction in relation CRP levels. To explore associations plasma with serum test on levels CRP. We included 2882 participants from Dongfeng-Tongji...
Introduction Complex lipids are important constituents of the central nervous system. Studies have shown that supplementation with complex milk (CML) in pregnancy may increase level fetal gangliosides (GA), potential to improve cognitive outcomes. Methods and analysis We aim recruit approximately 1500 pregnant women first trimester (11–14 weeks) randomise them into one three treatment groups: standard maternal formulation, CML-enhanced formulation or no intervention advice (ie, care)....
Benzo[a]pyrene (B[a]P) is a common environmental pollutant that neurotoxic to mammals, which can cause changes hippocampal function and result in cognitive disorders. The mechanisms of B[a]P-induced impairments are complex .To date there have been no studies on the association epigenetic, transcriptomic, metabolomic with neurotoxicity after B[a]P exposure. In present study, we investigated global effect DNA methylation patterns, noncoding RNAs (ncRNAs) expression, coding metabolites rat...
Cancer stem cells are regarded as the cause of tumour formation and recurrence in nasopharyngeal carcinoma (NPC). However, ideal surface markers for NPC remain unidentified. In present study, we investigated expression CD133, Nanog Sox2 cell line CNE2 primarily cultured using immunofluorescence or flow cytometry. A population with a CD133+ phenotype was enriched magnetic-activated sorting technology. We demonstrated that exhibited strong potential self-renewal, proliferation differentiation...
Evidence available on the independent and combined associations of sleep duration, bedtime, genetic predisposition with hearing loss was lacking. The present study included 15,827 participants from Dongfeng-Tongji cohort study. Genetic risk characterized by polygenic score (PRS) based 37 loci related to loss. We conducted multivariate logistic regression models assess odds ratio (OR) for duration as well joint association interaction PRS. Results showed that independently associated sleeping...
This study used data from the China Health and Retirement Longitudinal Study to investigate temporal relationship between blood lipids sleep duration in Chinese middle-aged older adults. We medical examinations questionnaire of 5,016 adults (age 45+) 2011 2015. Cross-lagged path analysis was performed examine bidirectional relationships duration. Sleep were analyzed as continuous variables. Temporal HDL-cholesterol, LDL-cholesterol, total cholesterol, triglycerides different. negatively...
Loss of β-cell mass and function can lead to insufficient insulin levels ultimately hyperglycemia diabetes mellitus. The mainstream treatment approach involves regulation levels; however, approaches intended increase are less developed. Promoting proliferation with low-molecular-weight inhibitors dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential treat oral therapies by restoring mass, content glycemic control. GNF4877, a potent dual inhibitor DYRK1A glycogen...
The role of lifestyle habits in patients with laryngopharyngeal reflux disease (LPRD) is comparatively underexplored. We aim to examine the specific LPRD.
DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the causality remains unclear cross-sectional studies. Here, we conduct a prospective epigenome-wide association study of incident ACS two Chinese cohorts (discovery: 751 nested case-control pairs; replication: 476 pairs). We identified and validated 26 differentially methylated positions (DMPs, false discovery rate [FDR] <0.05), including three mapped to known cardiovascular disease genes (PRKCZ, PRDM16,...