A5018393057- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- Cellular Mechanics and Interactions
- Orbital Angular Momentum in Optics
- Bone Metabolism and Diseases
- Lung Cancer Treatments and Mutations
- Bone and Dental Protein Studies
- Head and Neck Cancer Studies
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cytomegalovirus and herpesvirus research
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Genomics, phytochemicals, and oxidative stress
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
The First People's Hospital of Wenling
2019-2025
Wenzhou Medical University
2012-2025
Moffitt Cancer Center
2020-2024
Molecular Oncology (United States)
2024
University of Colorado Denver
2021-2024
University of Colorado Cancer Center
2021-2024
Zhuhai People's Hospital
2024
Southern Medical University
2017-2024
The past 5 years have witnessed the rise of highly efficient organometal halide perovskite-based solar cells. In conventional perovskite cells, compact n-type metal oxide film is always required as a blocking layer on transparent conducting (TCO) substrate for electron-selective contact. this work, an interface engineering approach demonstrated to avoid deposition film. Alkali salt solution was used modify TCO surface achieve optimized energy level alignment, resulting in A remarkable power...
With the advent of molecular electronics, tremendous attention has been paid towards understanding structure-function relationship junctions. Understanding how heat is transported, dissipated, and converted into electricity in junctions great importance for designing thermally robust circuits high-performance energy conversion devices. Further, study thermal thermoelectric phenomena provides novel insights limits applicability classical laws. Here, we present a review computational...
Systemic inflammation and immune dysfunction has been proved to be significantly associated with cancer progression metastasis in many types, including colorectal cancer. We examined the prognostic significance of systemic immune-inflammation index (SII) patients metastatic (mCRC) relationship between lymphocytic response tumor this index. This retrospective study evaluated 240 consecutive newly diagnosed stage IV mCRC who underwent surgical resection. The SII values were calculated based on...
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host EBV proteins during lytic gain insights into virus-host interactions, using conditional Burkitt lymphoma models type I II infection. quantified profiles >8,000 cellular 69 proteins, >500 plasma membrane providing views the proteome...
Abstract Growing evidence indicates that iron overload is an independent risk factor for osteoporosis. However, the mechanisms are not fully understood. The purpose of our study was to determine whether could lead ferroptosis in osteoblasts and explore involved overload‐induced osteoporosis vitro vivo. Ferric ammonium citrate used mimic conditions, while deferoxamine ferrostatin‐1 were inhibit MC3T3‐E1 cells vitro. ferroptosis, osteogenic differentiation mineralization assessed A mouse model...
Vessel co-option has been demonstrated to mediate colorectal cancer liver metastasis (CRCLM) resistance antiangiogenic therapy. The current mechanisms underlying vessel have mainly focused on "hijacker" tumor cells, whereas the function of "hijackee" sinusoidal blood vessels not explored. Here, we found that occurrence in bevacizumab-resistant CRCLM xenografts was associated with increased expression fibroblast activation protein α (FAPα) co-opted hepatic stellate cells (HSCs), which...
Osteoarthritis (OA) is a prevalent degenerative articular disease for which there no effective treatment. Progress has been made in mesenchymal stem cell (MSC)-based therapy OA, and the efficacy demonstrated to be result of paracrine exosomes from MSCs. Decellularized extracellular matrix (dECM) provides an optimum microenvironment expansion In present study, we aimed investigate whether isolated bone marrow cells (BMSCs) with dECM pretreatment (dECM-BMSC-Exos) enhance amelioration...
Osteonectin binds strongly to type I collagen and hydroxyapatite plays a crucial role in extracellular matrix mineralization. Previous studies have also shown that p38 signaling pathway is an important regulator for osteoblast This study focused on the of osteonectin regulating mineralization via pathway. Osteoblasts were isolated cultured from parietal bones neonatal Sprague-Dawley rats. The gene protein expressions noncollagen proteins (BSP, bone sialoprotein; OCN, osteocalcin; OPN,...
Neural networks have become one of the most popularly used methods in machine learning and artificial intelligence. Due to universal approximation theorem, a neural network with hidden layer can approximate any continuous function on compact support as long number units is sufficiently large. Statistically, be classified into nonlinear regression framework. However, if we consider it parametrically, due unidentifiability parameters, difficult derive its asymptotic properties. Instead,...
Abstract Background Neuronal structure is disrupted after spinal cord injury (SCI), causing functional impairment. The effectiveness of exercise therapy (ET) in clinical settings for nerve remodeling post-SCI and its underlying mechanisms remain unclear. This study aims to explore the effects related ET on SCI rats. Methods We randomly assigned rats various groups: sham-operated group, + ET, alone, H89, H89. Techniques including motor-evoked potential (MEP), video capture analysis,...
Background Pralsetinib is a selective RET inhibitor. The ARROW trial revealed that fusion-positive non-small-cell lung cancer (NSCLC) can benefit from pralsetinib with tolerable adverse events (AEs). However, the efficacy and safety of in real world has rarely been reported. Materials methods This study reviewed NSCLC patients between March 2021 December 2021. Progression-free survival (PFS) overall (OS) were evaluated by Kaplan-Meier analysis log-rank test. A Cox regression model was...
ABSTRACT Dysregulated transforming growth factor beta (TGF-β) signaling is associated with a spectrum of osseous defects as seen in Loeys-Dietz syndrome, Marfan and Camurati-Engelmann disease. Intriguingly, neurofibromatosis type 1 (NF1) patients exhibit many these characteristic skeletal features, including kyphoscoliosis, osteoporosis, tibial dysplasia, pseudarthrosis; however, the molecular mechanisms mediating phenotypes remain unclear. Here, we provide genetic pharmacologic evidence...
Differences between the features of primary cancer and matched metastatic have recently drawn attention in research. This study investigated concordance microsatellite instability (MSI) mismatch repair (MMR) status corresponding colorectal (CRC).Consecutive patients with CRC who had both tumors diagnosed at our institution January 2008 through December 2016 were identified. Immunohistochemistry was used to test MMR tumors, PCR analysis performed MSI deficient (dMMR) status.A total 369...
The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right cancer and left have different characteristics, this threshold value total number retrieved may not universally applicable. data 63,243 patients with treated between 2004 2012 were from the National Cancer Institute's Surveillance, Epidemiology, End Results database. Multivariate Cox regression analysis was used to determine predictive survival after adjusting ratio. in...
Purpose: We attempted to explore the prognostic value of baseline inflammatory and nutritional biomarkers at diagnosis in patients with early-stage breast cancer develop a novel scoring system, inflammatory-nutritional score (INPS). Patients Methods: collected clinicopathological laboratory data 1259 between December 2010 November 2012 from Sun Yat-sen University Cancer Center. Eligible were randomly divided into training validation cohorts (n = 883 376, respectively) 7:3 ratio. selected...