A5027388433- Immune Cell Function and Interaction
- X-ray Diffraction in Crystallography
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Crystallization and Solubility Studies
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cell Adhesion Molecules Research
- Cancer Treatment and Pharmacology
- Lanthanide and Transition Metal Complexes
- Analytical Chemistry and Sensors
- Chemokine receptors and signaling
- Microscopic Colitis
- RNA modifications and cancer
- Probiotics and Fermented Foods
- Luminescence Properties of Advanced Materials
- Advanced Breast Cancer Therapies
- Wnt/β-catenin signaling in development and cancer
- Genomics and Chromatin Dynamics
- Immune Response and Inflammation
- Inflammatory Bowel Disease
- PI3K/AKT/mTOR signaling in cancer
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2023
Jinan University
2023
Sichuan University
2020
Inserm
1993-2013
Contrôle transcriptionnel et épigénétique de l’hématopoïèse maligne
2013
École Normale Supérieure
2013
Institut Gustave Roussy
2012-2013
Georgetown University
2013
Kyoto University Hospital
2013
The chemokine receptor CXCR4 favors the interaction of acute myeloid leukemia (AML) cells with their niche but extent to which it participates in pathogenesis is unclear. Here, we show that expression at surface leukemic allowed distinguishing CXCR4high from CXCR4neg/low AML patients. When high levels are expressed cells, blocking function small molecule inhibitors could promote cell death and reduce NOD/Shi-scid/IL-2Rγnull (NOG) leukemia-initiating (LICs). Conversely, these drugs had no...
In the present study, a monoclonal antibody (McAb), ALD19, generated against myosin of slow tonic muscle, was shown to react with heavy chain ventricular in adult chicken heart. With this antibody, it possible detect ventricular-specific during myocardial differentiation and show that epitope recognized by ALD19 from earliest stages maintained throughout development only ventricle. A second McAb, specific for atrial (MHC) (Gonzalez-Sanchez, A., D. Bader, 1984, Dev. Biol., 103:151-158), used...
Human placenta contains, in addition to the ubiquitous p120-GTPase-activating protein (GAP), another isoform of 100 kDa, which is specific this organ. We have established a method for purifying placental p100-GAP near homogeneity. The purified allowed preparation polyclonal and monoclonal anti Ras-GAP antibodies. Two antibodies were selected two-site enzyme immunoassay. This simple accurate assay turn facilitated detection GAPs during purification. has activity identical catalytic properties...
This study aimed to determine the impact of Lactobacillus plantarum PC170 concurrent with antibiotic treatment and/or during recovery phase after on body weight, faecal bacterial composition, short-chain fatty acids (SCFAs) concentration, and splenic cytokine mRNA expression mice. Orally administrated ceftriaxone quantitatively significantly decreased total bacteria, Akkermansia muciniphila , SCFAs concentration. Ceftriaxone also dramatically altered microbiota an increased Chao1 index,...
Abstract Inflammatory bowel disease (IBD), mainly including ulcerative colitis and Crohn’s disease, imposes a huge medical economic burden worldwide. Recently, the diagnosis, treatment, surveillance of IBD have advanced rapidly, which has changed epidemiology, cancer risk, surgery risk IBD. Here, we reviewed recent literature on IBD-related cancer, surgery. We created choropleth map to show worldwide incidence trend for colitis. also found that are declining discussed some factors associated...
Abstract Background: Activation of the PI3K/mTOR pathway is thought to be involved in resistance TRAS. BOLERO-3 a randomized phase 3, double-blind, placebo-controlled, international, clinical trial evaluating addition mTOR inhibitor EVE (5 mg/day) TRAS plus vinorelbine (25 mg/m2) patients with HER2+ advanced breast cancer resistant and who were previously treated taxane. A total 569 adult women 1:1 receive (n = 284) or PBO 285). Study treatment represented 2nd, 3rd, 4th line...