A5047194422- Gut microbiota and health
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Infant Nutrition and Health
- Clostridium difficile and Clostridium perfringens research
- Digestive system and related health
- Pediatric health and respiratory diseases
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
- Infant Health and Development
- Gastrointestinal motility and disorders
- Gestational Diabetes Research and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- Protein Hydrolysis and Bioactive Peptides
- Obesity, Physical Activity, Diet
- Food Allergy and Anaphylaxis Research
- Microbial Metabolites in Food Biotechnology
- Pharmacological Effects of Natural Compounds
- Allergic Rhinitis and Sensitization
- Immune Cell Function and Interaction
- Microbial Inactivation Methods
- Bariatric Surgery and Outcomes
Sichuan University
2016-2025
Wuhan Third Hospital
2025
Wannan Medical College
2024
Third Affiliated Hospital of Guangzhou Medical University
2016-2023
Guangzhou Medical University
2016-2023
Hunan Academy of Agricultural Sciences
2023
Peking University
2013-2023
Peking Union Medical College Hospital
2023
Southern Medical University
2023
Hunan Provincial Center for Disease Control and Prevention
2023
Fifty bifidobacteria strains were isolated from fecal samples of allergic and age matched healthy infants. Allergic infants found to have an adult type Bifidobacterium flora with high levels adolescentis. Healthy had a typical infant bifidum. These isolates tested for their adhesive properties human intestinal mucus. The adhesion the was significantly higher (P<0.0001) than This suggests correlation between disease composition which has reduced abilities Therefore, dietary supplementation...
Aims: To investigate whether intranasal Lactobacillus administration protects host animals from influenza virus (IFV) infection by enhancing respiratory immune responses in a mouse model. Methods and Results: After 3 days of exposure to rhamnosus GG (LGG), BALB/c mice were infected with IFV A/PR/8/34 (H1N1). Mice treated LGG showed lower frequency accumulated symptoms higher survival rate than control (P < 0·05). The YAC-1 cell-killing activity lung cells isolated was significantly greater...
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes mellitus and the mechanisms underlying effects A. on mellitus. Normal streptozotocin-induced diabetic Sprague-Dawley rats were orally administered with solvent. After 4 weeks of treatment, live or pasteurized exhibited significant increase in blood concentration high-density lipoprotein, decrease hepatic glycogen, serum plasminogen activator inhibitor-1, tumor necrosis factor-α, lipopolysaccharide,...
Purpose: To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using randomized, blank-controlled, parallel-group design. Patients methods: Two hundred five volunteers aged ≥45 years were randomly divided into two groups. The subjects in the intervention group orally administered 300 mL/d of strain, Lactobacillus paracasei N1115 (N1115), 3.6×10 7 CFU/mL for 12 weeks, while those...
Aims: Our study was conducted to evaluate the potent protective effects of oral administration probiotic Lactobacillus strains against influenza virus (Flu) infection in a mouse model. Method and Results: Lyophilized rhamnosus GG (LGG) gasseri TMC0356 (TMC0356) were orally administered BALB/c mice for 19 days. The test intranasally infected with Flu A/PR/8/34 (H1N1) on day 14, any changes clinical symptoms monitored. After 6 days infection, killed pulmonary titres determined. symptom scores...
This study investigated whether heat-killed Lactobacillus protects host animal against influenza virus infection and stimulates their immunity. Heat-killed gasseri TMC0356 was orally administered to BALB/c mice for 19 days; the were intranasally infected with Flu A/PR/8/34 (H1N1) on day 14, clinical symptoms monitored. After 6 days, sacrificed, pulmonary titres determined. Splenic activation of natural killer (NK) cells mRNA expression cytokines other immune molecules in lung Peyer's patch...
The antidiabetic effects of lactic acid bacteria were investigated using mice. In Experiment 1, normal ICR mice loaded with sucrose or starch without viable Lactobacillus rhamnosus GG cells. significantly inhibited postprandial blood glucose levels when administered starch. 2, KK-Ay mice, a model genetic type 2 diabetes, given basal diet containing cells delbrueckii subsp. bulgaricus for 6 weeks. Viable fasting glucose, in tolerance test and HbA1c. Such not shown by L. 3, the heat-treated 3...
The present study was conducted to investigate the possible association between gut microbes and immunity among healthy middle-aged elderly individuals in southwest China. A total of 148 adults aged ≥ 50 years were divided into two age groups: group (50-59 years; n = 67, 54.13 ± 3.32) (≥ 60 81, 64.70 3.93). Blood samples collected measure serum immune biochemical indices. Gut microbiota compositions groups characterized on basis faecal DNA using 16S rRNA gene sequencing.Among detected...
This study was conducted to investigate the effects of a high-fat diet (HFD) and high-cholesterol (HFHCD) on glucose lipid metabolism intestinal microbiota host animal. A total 30 four-week-old female C57BL/6 mice were randomly divided into three groups (n=10) fed with normal (ND), HFD, or HFHCD for 12 weeks, respectively. The HFD significantly increased body weight visceral adipose accumulation partly lowered oral tolerance compared ND HFHCD. liver weight, fat infiltration, triglycerides,...
To date, the prevalence of Gestational diabetes mellitus (GDM) in China was 17.5%. Given substantial relevance GDM for medium- and long-term health both mother offspring paucity existing data on link between maternal diet glucose homeostasis during pregnancy Asian population, additional studies are needed. examine dietary glycemic index (GI), load (GL) fiber intake before development over course pregnancy.Cox proportional hazards analysis linear mixed effects regressions were performed from...
Research on regulating brain functions with probiotics and postbiotics through the gut-brain axis is attracting attention, offering possibility of adjuvant therapy for Alzheimer's disease (AD). Three-month-old male APP/PS1 mice were gavaged live heat-inactivated S. thermophilus MN-002 three months. This study demonstrated that improved cognitive dysfunctions in mice, especially spatial memory. However, main effects directly altered intestinal microbiota composition increased serum IL-1β...
Eleven strains of lactobacilli were tested for their ability to induce the murine macrophage-like cell line J774.1 secrete cytokines. Some bacteria production interleukin(IL) 6, IL-12, and tumor necrosis factor α (TNF-α) by cells. Seven also induced IL-10. However, no IL-1β was produced. Lactobacillus acidophilus TMC 0356 significantly more IL-6, IL-10, TNF-α than other (p<0.0001; ANOVA). These results suggest that can activate macrophages both inflammatory anti-inflammatory Selected might...
Abstract To characterize the ability of bifidobacteria to affect production macrophage‐derived cytokines, a murine macrophage‐like cell line, J774.1, was cultured in presence 27 strains heat‐inactivated bifidobacteria. Bifidobacterium adolescentis and B. longum , known as adult‐type bifidobacteria, induced significantly more pro‐inflammatory cytokine secretion, IL‐12 TNF‐α, by J774.1 cells, than did infant‐type bifidum, breve infantis ( P <0.01). In contrast, not stimulate...
Summary Background Continuous oral administration of live Lactobacillus rhamnosus GG ( L . GG) to pregnant subjects with atopic dermatitis and their children, suppressed the frequency dermatitis. The details mechanisms immune systems involved in this suppressive effect, however, remain speculative. Objective We sought clarify on by using NC/Nga mice, a model human Methods Maternal mice infant were fed food containing or not heat‐treated during pregnancy breastfeeding, after weaning. Results...
This double-blind, placebo-controlled clinical trial was conducted to test whether Lactobacillus gasseri TMC0356 (TMC0356) can modify the immune response in elderly. Heat-killed or placebo orally administered 28 healthy subjects aged 50-70 years old for 4 weeks at a dosage of 1.0×10 9 cfu/day. Peripheral blood mononuclear cells (PBMCs) were collected from before and after study completion, together with general health examination records. Isolated PBMCs examined number T cells, CD8 + CD28...
Gut microbes have been suggested as the possible targets in management of allergic diseases. However, way which these influence diseases remain unclear. Forty-seven full-term newborns were selected from a 1000-infant birth cohort. Among them 23 infants, whereas 24 infants healthy without symptoms at 1 year age. Two hundred and sixty-four fecal samples collected 7 time points following their birth. These microbiologically analyzed using 16S rRNA gene sequencing. The dynamic processes involved...
This study investigated the gut microbiota and short chain fatty acids (SCFAs) characteristics of subjects with obesity from Xinjiang in northwestern China, a region multiethnic culture characteristic lifestyle, to explore potential microbes that respond 12-wk medication orlistat ezetimibe randomized controlled open-label trial manner. The profile patients overweight dyslipidemia was distinctive characterized by enrichment Lactobacillus reduction diversity depletion Actinobacteria ,...
Gut microbiota depletion may result in cognitive impairment and emotional disorder. This study aimed to determine the possible association between host gut microbiota, function, emotion various life stages its related underlying mechanisms. Seventy-five neonatal mice were randomly divided into five groups (n = 15 per group). Mice vehicle group administered distilled water from birth death, those last four antibiotic cocktail postnatal day (PND) 21 (infancy), PND 56 (adolescence), 57 84...