A5100374845- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cerebral Palsy and Movement Disorders
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Botulinum Toxin and Related Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Parkinson's Disease Mechanisms and Treatments
- Signaling Pathways in Disease
- Pancreatic and Hepatic Oncology Research
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Long-Term Effects of COVID-19
- Circular RNAs in diseases
First Affiliated Hospital of Anhui Medical University
2009-2025
Anhui Medical University
2009-2025
Nanfang Hospital
2021-2025
Southern Medical University
2021-2025
Shandong First Medical University
2021-2025
Shandong Tumor Hospital
2021-2025
Peking University Cancer Hospital
2023-2024
Affiliated Hospital of Qingdao University
2015-2024
Affiliated Hospital of Southwest Medical University
2019-2024
Beijing University of Posts and Telecommunications
2024
To characterize the chest computed tomography (CT) findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) according to clinical severity. We compared CT features common cases and cases, symptomatic patients asymptomatic patients, febrile afebrile patients. This was a retrospective analysis thoracic 120 consecutive with confirmed SARS-CoV-2 pneumonia admitted tertiary university hospital between January 10 February 10, 2020, in Wuhan city, China. On admission, generally...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and accumulation extracellular matrix (ECM). Ferroptosis novel form cell death the lethal iron lipid peroxidation, which associated with many diseases. Our study addressed potential role played ferroptosis in progression fibrosis. We found that inducers injury, namely, bleomycin (BLM) lipopolysaccharide (LPS), induced lung epithelial cells. Both inhibitor...
Purpose: To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using randomized, blank-controlled, parallel-group design. Patients methods: Two hundred five volunteers aged ≥45 years were randomly divided into two groups. The subjects in the intervention group orally administered 300 mL/d of strain, Lactobacillus paracasei N1115 (N1115), 3.6×10 7 CFU/mL for 12 weeks, while those...
Rheumatoid arthritis (RA) is a common chronic, inflammatory autoimmune disease, and early clinical diagnosis crucial for its treatment. CXCR4 expression was characterized in arthritic mouse models joints of RA patients, [18 F]AIF-NOTA-QHA-04 specificity assessed non-malignant cells with elevated expression. This study explored the application CXCR4-targeted PET probe monitoring disease activity therapeutic efficacy RA. To this aim, metabolic characteristics correlation uptake severity were...
Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene can cause late-onset Parkinson disease (PD). LRRK2 increase activities that may levels of autophosphorylation at serine 1292 (pS1292) and neurotoxicity model systems. pS1292-LRRK2 protein be packaged into exosomes measured biobanked urine. Herein we provide evidence is robustly expressed cerebral spinal fluid (CSF) exosomes. In a novel cohort Norwegian subjects with without G2019S-LRRK2 mutation, PD, quantified pS1292-LRRK2,...
Autophagy is a common strategy for cell protection; however, some viruses can in turn adopt cellular autophagy to promote viral replication. Zika virus (ZIKV) the pathogen that causes disease, and it mosquito-borne virus. However, its pathogenesis, especially interaction between ZIKV target cells during early stages of infection, still unclear. In this study, we demonstrate infecting human umbilical vein endothelial (HUVEC) with triggers autophagy. We observed both an increase conversion...
Ferroptosis, a form of programmed cell death process driven by iron-dependent lipid peroxidation, plays an important role in tumor suppression. Although previous study showed that intracellular Merlin-Hippo signaling suppresses ferroptosis epithelial cells through the inactivation YAP signaling, it remains elusive if proto-oncogenic transcriptional co-activator could serve as potential biomarker to predict cancer response ferroptosis-inducing therapies. In this study, we show both total...
Abstract Background and Aims The incidence of HCC has recently been consistently reported to decline in the United States. However, decreased overall mortality just suggested needs further examination. Approach Results Using data from Surveillance, Epidemiology, End databases, we assessed incidence, incidence‐based (IBM), 1‐year survival rates 1992 through 2017 These secular trends were analyzed using National Cancer Institute’s Joinpoint Regression Program. Age‐period‐cohort analyses...
// Zhi-guang Fu 1, * , Li Wang 2, Hong-yong Cui Jian-long Peng 3 Shi-jie 1 Jie-jie Geng Ji-de Liu Fei Feng Song Ling Ping Zhu 4 Jian-li Jiang Zhi-nan Chen Cell Engineering Research Center & Department of Biology, State Key Laboratory Cancer National Discipline Fourth Military Medical University, Xi’an, P.R. China 2 Pharmacogenomics, School Pharmacy, Drug Discovery and Design Center, Research, Shanghai Institute Materia Medica, Chinese Academy Sciences, Shanghai, Clinical...
Abstract Background Pathogenic leucine‐rich repeat kinase 2 LRRK2 mutations may increase activity and Rab substrate phosphorylation. Genetic association studies link variation in to idiopathic Parkinson disease (iPD) risk. Objectives Through measurements of the pT73‐Rab10 urinary extracellular vesicles, this study seeks understand how might change with iPD progression. Methods Using an immunoblotting approach validated transgenic mice, ratio total Rab10 protein was measured vesicles from a...
Pancreatic cancer is a highly lethal solid malignancy with limited treatment options. Chimeric antigen receptor T (CAR-T) cell therapy has been successfully applied to treat hematological malignancies, but faces many challenges in tumors. One major challenge the shortage of tumor-selective targets. Cell surface GRP78 (csGRP78) expressed on various cells including pancreatic cancer, not normal cells, providing potential target for CAR-T cancer. Here, we demonstrated that csGRP78-directed...
Abstract Background Acupuncture is used to treat chronic functional constipation ( CFC ) in China, despite limited evidence. We aim assess the effectiveness and safety of acupuncture managing . Methods A multicenter randomized controlled trial was performed involving 684 patients with ; were randomly allocated receive He (n = 172), Shu‐mu 171), He‐shu‐mu or oral administration mosapride 170). Sixteen sessions given treatment duration 4 weeks. The primary outcome change spontaneous bowel...
Background: Limited research exists on colorectal cancer (CRC) patients with bladder invasion, survival outcomes post-cystectomy underexplored and a debate between partial total cystectomy ongoing. Objective: The study aimed to evaluate the effect of pathological invasion long-term tumour prognosis clinically diagnosed in CRC after cystectomy. Design: Retrospective, cohort study. Methods: Our involving 105 who had or from 2012 2020 collected surgical data. Groups were divided by presence...
Purpose Our previous study showed that circulating tumor cell (CTC) count combined with gene mutation detection might help differentiate benign and malignant pulmonary nodules (PNs). Herein, we aimed to expand the cohort conduct further sequencing analysis. Materials Methods Patients PNs were included, CTCs identified before operation. Low-coverage whole-genome (LC-WGS) lung cancer-related targeted performed on CTCs. The diagnostic efficacy was evaluated by receiver operator characteristic...
Colorectal cancer (CRC) is a serious threat to human health and drug-resistant. Circular RNA _0004585 (circ_0004585) has been shown be expressed in CRC, but whether it plays role CRC with chemoresistance remains unknown. Therefore, this study aimed investigate the potential of circ_0004585 5-fluorouracil (5-FU) resistance.The expression related genes was detected by quantitative real-time polymerase chain reaction (qRT-PCR), protein expressions cleaved caspase-3, caspase-9, cyclin D1 (CCND1)...
The Presenilin (Psn) gene is closely related to aging, but it still unclear the role of Psn genes in skeletal muscle. Here, Psn-UAS/Mhc-GAL4 system Drosophila was used regulate muscle overexpression(MPO) and knockdown(MPK). were subjected endurance exercise from 4 weeks 5 old. results showed that MPO significantly increased climbing speed, endurance, lifespan, SOD activity, expression, Sirt1 PGC-1α armadillo (arm) expression aged Drosophila, they decreased malondialdehyde levels....