A5100424421- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- Biosensors and Analytical Detection
- Supramolecular Self-Assembly in Materials
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Polymer Surface Interaction Studies
- DNA and Nucleic Acid Chemistry
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Glioma Diagnosis and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
- Advanced Biosensing Techniques and Applications
- Hydrogels: synthesis, properties, applications
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Research and Treatments
- Estrogen and related hormone effects
University of Colorado Anschutz Medical Campus
2025
Pennsylvania State University
2016-2025
Shandong Tumor Hospital
2019-2025
Shandong First Medical University
2019-2025
Nanjing University of Aeronautics and Astronautics
2013-2025
University of Aberdeen
2025
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Second Affiliated Hospital of Nanjing Medical University
2006-2024
Zhengzhou University
2015-2024
Applying an electrical field to a polar polymer may induce large change in the dipolar ordering, and if associated entropy changes are large, they can be explored cooling applications. With use of Maxwell relation between pyroelectric coefficient electrocaloric effect (ECE), it was determined that ECE realized ferroelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] copolymer at temperatures above ferroelectric-paraelectric transition (above 70 degrees C), where isothermal...
Abstract National-based prospective surveillance of all-age patients with acute diarrhea was conducted in China between 2009‒2018. Here we report the etiological, epidemiological, and clinical features 152,792 eligible enrolled this analysis. Rotavirus A norovirus are two leading viral pathogens detected patients, followed by adenovirus astrovirus. Diarrheagenic Escherichia coli nontyphoidal Salmonella bacterial pathogens, Shigella Vibrio parahaemolyticus . Patients aged <5 years had...
The interaction between nuclear receptors and coactivators provides an arena for testing whether protein–protein interactions may be inhibited by small molecule drug candidates. We provide evidence that a short cyclic peptide, containing copy of the LXXLL receptor box pentapeptide, binds tightly selectively to estrogen α. Furthermore, as shown x-ray analysis, disulfide-bridged nonapeptide, nonhelical in aqueous solutions, is able adopt quasihelical conformer while binding groove created...
A novel 814 nm near-infrared surface plasmon resonance (SPR) microscope is used for the real-time detection of sequence-selective hybridization adsorption single DNA-functionalized gold nanoparticles. The objective-coupled, high numerical aperture SPR capable imaging in situ polystyrene and particles with diameters ranging from 450 to 20 onto a 90 μm × 70 area thin film time resolution approximately 1-3 s. Initial (SPRI) measurements were performed detect accumulation 40 nanoparticles 10 min...
Polymeric delivery systems have been extensively studied to achieve localized and controlled release of protein drugs. However, it is still challenging control the multiple drugs in distinct stages according progress disease or treatment. This study successfully demonstrates that can be released from aptamer-functionalized hydrogels with adjustable rates at predetermined time points using complementary sequences (CSs) as biomolecular triggers. Because both aptamer-protein interactions...
A supramolecular gel was constructed by using an imidazolium-based surfactant, N-cetyl-N'-carboxymethyl imidazolium bromide ([N-C16, N'-CO2H-Im]Br), in the DMSO/H2O binary solvent mixtures and investigated as adsorbent for removing dyes from aqueous solution. The self-assembled displays a morphology of microplatelets stacked bilayer units with interdigitated hydrocarbon tails, structure remains unchanged below sol-gel transition temperature. also exhibits strong birefringence property...
Abstract Mammalian cells are different from plant and microbial cells, having no exterior cell walls for protection. Environmental assaults can easily damage or destroy mammalian cells. Thus, the ability to develop a biomimetic wall (BCW) on their plasma membrane as shield advance various applications. Here we demonstrate synthesis of BCW with framing template crosslinked matrix shielding live The is supramolecular DNA structure. polyelectrolyte complex made alginate polylysine. As entire...
An ability to promote therapeutic immune cells recognize cancer is important for the success of cell-based immunotherapy. We present a synthetic method functionalizing surface natural killer (NK) with supramolecular aptamer-based polyvalent antibody mimic (PAM). The PAM synthesized on cell through nucleic acid assembly and hybridization. data show that has superiority over its monovalent counterpart in powering NKs bind cells, PAM-engineered NK exhibit capability killing more effectively....
In piezoelectric energy harvesting systems, the circuit is interface between a device and an electrical load. A conventional view of this based on impedance matching concepts. fact, can also apply boundary conditions, such as voltage charge, to for each conversion cycle. An optimized condition therefore increase mechanical flow into efficiency device. We present study active harvesting, type approach which uses switch-mode power electronics control and/or charge relative input conversion....
Hydrogel functionalization with DNA aptamers can be applied for developing a novel sustained-release system.
Phosphoinositide-3 kinase (PI3K)/Akt signaling is activated by growth factors such as insulin and epidermal factor (EGF) regulates several functions cell cycling, apoptosis, growth, migration. Here, we find that Kank an Akt substrate located downstream of PI3K a 14-3-3–binding protein. The interaction between 14-3-3 regulated EGF mediated through phosphorylation Akt. In NIH3T3 cells expressing Kank, the amount actin stress fibers reduced, coexpression disrupted this effect. also inhibits...
In situ injectable hydrogels hold great potential for in vivo applications such as drug delivery and regenerative medicine. However, it is challenging to ensure stable sequestration sustained release of loaded biomolecules these hydrogels. As aptamers have high binding affinities specificities against target biomolecules, we studied the capability functionalizing fibrin (Fn) two growth factors including vascular endothelial factor (VEGF) platelet-derived factor-BB (PDGF-BB). The results show...
Clinically, breast cancer is generally classified into estrogen receptor-positive (ER+) or receptor-negative (ER−) subtypes. The phytoestrogen calycosin has been shown to inhibit the proliferation of ER+ cells, which may be mediated by a feedback loop that involves miR-375, RAS dexamethasone-induced 1 (RASD1), and ERα. However, how acts on ER− cells remains unclear. Here, we show inhibited both (MDA-MB-468 SKBR3) (MCF-7 T47D) these inhibitory effects were associated with up-regulation long...
Abstract Surface display of biomolecules on live cells offers new opportunities to treat human diseases and perform basic studies. Existing methods are primarily focused monovalent functionalization, that is, the single across cell surface. Here we show surface can be functionalized polyvalent biomolecular structures through two‐step reactions under physiological conditions. This functionalization enables recognize microenvironment one order magnitude more effectively than with...
Various in situ injectable hydrogels have been developed for protein delivery treating human diseases. However, most are highly permeable, which can lead to the rapid release of loaded proteins. The purpose this study is apply nucleic acid aptamers functionalize an hydrogel model control were studied using secondary structural predictions and binding analyses. results showed that different from experimental measurements numerous cases. affinity aptamer was significantly affected by mutations...
A water-soluble palladium complex (PdLn@β-CD) was designed and prepared based on functionalized β-cyclodextrin. It showed high turnover numbers (TONs) frequencies (TOFs) of up to 9.9 × 108 4.9 h−1, respectively, in aqueous Suzuki–Miyaura coupling reactions. The detailed reason for the excellent catalytic activity studied.