A5056946780- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Metabolism, Diabetes, and Cancer
- Nanocluster Synthesis and Applications
- Genetic Associations and Epidemiology
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer therapeutics and mechanisms
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Parallel Computing and Optimization Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Crystallization and Solubility Studies
- Diet, Metabolism, and Disease
- Neuroscience and Neuropharmacology Research
- Polymer-Based Agricultural Enhancements
- Advanced Biosensing Techniques and Applications
- Histone Deacetylase Inhibitors Research
Binzhou University
2016-2025
Binzhou Medical University
2016-2025
Zhejiang University
2024-2025
Westlake University
2021-2024
Central South University
2021-2024
Target (United States)
2024
Xiangya Hospital Central South University
2024
Kingmed Diagnostics
2024
Imperial College London
2024
Shenzhen Second People's Hospital
2024
Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates the antidiabetic drug metformin could be suitable for diabetic patients with cognitive impairment. However, there no direct from clinical studies treatment improves function in suffering In present study, 58 participants diagnosed depression type 2 diabetes (T2DM)...
Abstract We initiate the Westlake BioBank for Chinese (WBBC) pilot project with 4,535 whole-genome sequencing (WGS) individuals and 5,841 high-density genotyping individuals, identify 81.5 million SNPs INDELs, of which 38.5% are absent in dbSNP Build 151. provide a population-specific reference panel an online imputation server ( https://wbbc.westlake.edu.cn/ ) could yield substantial improvement performance population, especially low-frequency rare variants. By analyzing singleton density...
Abstract Background The prognostic value of triglyceride-glucose (TyG) index in general type 2 diabetes mellitus (T2DM) patients is still unclear. Therefore, we aimed to determine the associations between TyG and all-cause/cause-specific death a T2DM cohort explore whether such would be modified by age. Methods A total 3,376 with from National Health Nutrition Examination Survey (NHANES) 1999–2018 were selected divided into younger group (< 65 yrs) older (≥ yrs). Baseline was calculated...
Controlled release of pesticides by light regulation is one the most viable strategies recently developed for highly efficient utilization agrochemicals. Herein, we report an infrared-light-responsive pesticide delivery system controlled imidacloprid (IMI) preparation functional hollow carbon microspheres (HCMs). After IMI loading and surface functionalization with polyethylene glycol (PEG) α-cyclodextrin (α-CD), was sequestered in (denoted as HCMs/IMI/PEG/α-CD) a result formation PEG/α-CD...
Although VEGF-B was discovered as a VEGF-A homolog long time ago, the angiogenic effect of remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit together other VEGF family members are being used to treat patients various neovascular diseases. It is therefore critical have better understanding underlying mechanisms. Using comprehensive in vitro vivo methods models, we reveal here for first an unexpected surprising function...
In piezoelectric energy harvesting systems, the circuit is interface between a device and an electrical load. A conventional view of this based on impedance matching concepts. fact, can also apply boundary conditions, such as voltage charge, to for each conversion cycle. An optimized condition therefore increase mechanical flow into efficiency device. We present study active harvesting, type approach which uses switch-mode power electronics control and/or charge relative input conversion....
Abstract Herein, a ccRCC targeting nanodrug is designed to enhance chemodynamic therapy (CDT) as well activate cuproptosis and tumor immunotherapy via cell membrane modifying CuO@Gd 2 O 3 yolk‐like particles (CGYL) loaded with lactate oxidase (LOx) (mCGYL‐LOx). Benefiting from the homologous effect of Renca membranes, mCGYS‐LOx can be effectively internalized by cells, open “gate”, then release LOx copper (Cu) ions. catalyze excessive in cells into H , following that produced further...
Theoretically, the Fenton catalytic efficiency of Cu-based nanoplatform is approximately 160 times that traditional Fe-based agents. However, coordination interaction between Cu(ii) and intracellular GSH significantly inhibits high activity Cu(i) generation, dramatically decreasing Fenton-like efficiency. Herein, we designed a completely new highly efficient hierarchical structural to enhance mimic-peroxidase through utilizing comproportionation CuO elemental Cu core self-supply Cu(i). The...
Background: Evaluating the risk of metastasis and recurrence a cervical cancer patient is critical for appropriate adjuvant therapy. However, current assessment models usually involve testing tens to thousands genes from patients’ tissue samples, which expensive timeconsuming. Therefore, computer-aided diagnosis prognosis prediction based on Hematoxylin Eosin (H&E) pathological images have received much attention recently. Objective: The whether patients will can support accurate...
Abstract Tumor hypoxia and systemic toxicity seriously affect the efficacy of photodynamic therapy (PDT) are considered as “Achilles’ heel” PDT. Herein, to combat such limitations, an intelligent orthogonal emissions LDNP@SiO 2 ‐CaO folic acid‐polyethylene glycol‐Ce6 nanodrug is rationally designed fabricated not only for relieving hypoxic tumor microenvironment (TME) enhance PDT efficacy, but also determining optimal triggering time through second near‐infrared (NIR‐II) fluorescence...
Abstract As one of the most significant imaging modalities currently available, magnetic resonance (MRI) has been extensively utilized for clinically accurate cancer diagnosis. However, low signal-to-noise ratio (SNR) and specificity tumors continue to pose challenges. Inspired by distance-dependent tuning (MRET) phenomenon, tumor microenvironment (TME)-activated off–on T 1 –T 2 dual-mode MRI nanoswitch is presented in current study realize sensitive early diagnosis tumors. The...
Autophagy generally functions as a cellular surveillance mechanism to combat invading viruses, but viruses have evolved various strategies block autophagic degradation and even subvert it promote viral propagation. White spot syndrome virus (WSSV) is the most highly pathogenic crustacean virus, little currently known about whether such WSSV can for escape. Here, we show that though proliferation triggers accumulation of autophagosomes, blocked in species red claw crayfish. Interestingly,...
The formation of blood vessel system under a relatively higher Cu
Photothermal therapy (PTT) combined with chemotherapy has been highly desirable to improve the tumor treatment efficacy. Here, we report a novel controlled release nano-carrier system named Se-PEG-Au NPs-DOX (SePAD) for achieving chemo-photothermal synergistic therapy. In this system, diselenide-containing co-polymers (mPEG-Se–Se-PEGm) were anchored onto surface of Au NPs via AuSe interactions and soluble chemotherapeutic doxorubicin (Dox) was loaded into monolayers. This structure is proved...
Estrogen-related receptor α (ERRα) is dysregulated in many types of cancer and exhibits oncogenic activity by promoting tumorigenesis metastasis cells. However, its defined role renal cell carcinoma (RCC) has not been fully elucidated. To reveal the biological function ERRα determine underlying regulatory mechanism RCC, quantitative proteomics analysis investigation were conducted. The results demonstrated that promoted proliferation RCC cells maintaining lysosome-dependent autophagy flux....
Electrochromic fabrics (ECFs) can be applied to wearable displays and military camouflage clothing, they have great potential in developing products. Current ECFs are often bulky, involve complicated processes, high production costs. In this study, we report a novel strategy for preparing electrochromic that require only three-layer structure: cotton fabric as the substrate, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) layer electrodes, an ion-conducting film (ICF)...
// Geng Tian 1, * , Fangrong Tang 2, Chunhua Yang 1 Wenfeng Zhang 2 Jonas Bergquist 3 Bin Wang Jia Mi and Jiandi Medicine Pharmacy Research Center, Binzhou Medical University, Yantai, P. R. China Yantai Zestern Biotechnique Co. LTD, Department of Chemistry, BMC, Uppsala Uppsala, Sweden These authors have contributed equally to this work Correspondence to: Zhang, email: Jiandi.zhang@zestern.net Mi, jiajiami@gmail.com Keywords: quantitative dot blot, high throughput, proteomics, immunoblot...
Chronic palmitate exposure impairs glucose-stimulated insulin secretion and other aspects of β-cell function, but the underlying mechanisms are not known. Using various live-cell fluorescence imaging approaches, we show here that long-term treatment influences cAMP signaling in pancreatic β-cells. Glucose stimulation mouse human β-cells induced oscillations subplasma-membrane concentration, after 48 h to palmitate, most failed increase response glucose. In contrast, GLP-1–triggered formation...