A5100403354- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- CRISPR and Genetic Engineering
- Angiogenesis and VEGF in Cancer
- Animal Genetics and Reproduction
- Cancer Research and Treatments
- Handwritten Text Recognition Techniques
- FOXO transcription factor regulation
- Vehicle License Plate Recognition
- S100 Proteins and Annexins
- Dental Implant Techniques and Outcomes
- RNA Interference and Gene Delivery
- Dental Radiography and Imaging
- Adipose Tissue and Metabolism
- Advanced Nanomaterials in Catalysis
- Periodontal Regeneration and Treatments
- dental development and anomalies
- Neonatal Respiratory Health Research
- Bone and Dental Protein Studies
Shanghai Jiao Tong University
2010-2023
Anhui Medical University
2023
Shanghai Ninth People's Hospital
2010-2021
National Clinical Research
2021
Stomatology Hospital
2021
Dongguan People’s Hospital
2020
Shanghai Children's Medical Center
2018-2019
The epithelial-mesenchymal transition (EMT) is a crucial step in epithelial cancer invasion and metastasis. aims of this study were to investigate validate unidentified micro RNAs (miRNAs) that regulate EMT reveal their clinical relevance patients. By applying miRNA array screening natural phenotype cell line pair transforming growth factor β-induced model, we found miR-153 was markedly downregulated the cells underwent an EMT. A close association confirmed between inhibition phenotype, as...
Abstract Background To identify new and useful candidate biomarkers in head neck squamous cell carcinoma (HNSCC), we performed a genome-wide survey found that Myelin lymphocyte-associated protein (MAL) was gene markedly down-regulated HNSCC. Hence, investigated the mechanism of MAL silencing effects on proliferation, invasion, apoptotic potential Results significantly 91.7% HNSCC specimens at mRNA level as compared with adjacent normal tissues ( P = 0.0004). Moreover, relative transcript...
Abstract Breast cancer (BC) is a common with poor survival. The present study aimed to explore the effect of miR-940 on process BC cells and its target gene FOXO3. expression was assessed in tissues using qRT-PCR. Furthermore, correlation between prognosis patients from TCGA database analyzed. CCK8 assays colony formation were used cell proliferation. invasion abilities detected by transwell assays. Luciferase reporter assay performed scrutinize relationship Finally, rescue experiments...
J Oral Pathol Med (2013) 42 : 140–147 Background: The carcinogenesis mechanism of adenoid cystic carcinoma (ACC) the salivary gland is poorly understood. MicroRNA155 (miRNA155) has been involved in many malignant tumors. present study aims to examine role miRNA155 tumor growth and invasion ACC. Methods: MiRNA155 expression was determined ACC specimens along with normal glands by quantitative PCR. Using ACC‐2 cells as a model for ACC, cell proliferation examined MTT assay after knocking down...
Dentigerous cysts are thought to be caused by a developmental abnormality derived from the reduced enamel epithelium of tooth forming organ. Most typical dentigerous those associated with third molar teeth mandible, but rarely involve impacted supernumerary in anterior maxilla. Swelling and/or pain may major complaints patients. Herein, we review literature spanning past 22 years concerning maxilla, and present four additional cases emphasis given clinicopathological characteristics this type cyst.
Abstract Recently, Leydig cell (LC) transplantation has been revealed as a promising strategy for treating male hypogonadism; however, the key problem restricting application of LC is severe lack seed cells. It seems that targeted activation endogenous genes may provide potential alternative. Therefore, aim this study was to determine whether Nr5a1 , Gata4 and Dmrt1 (NGD) via CRISPR/dCas9 synergistic mediator system could convert human foreskin fibroblasts (HFFs) into functional Leydig‐like...
Annexin A1, a member of the superfamily, has been shown to play vital role in broad range molecular and cellular processes. This study aims explore relationship between A1 expression clinical response cisplatin, docetaxel 5-fluorouracil (TPF) as induction chemotherapy patients with oral squamous cell carcinoma (OSCC).This recruited two hundred thirty-two from III/IVA OSCC trial. Immunohistochemistry was used assess level expression. Overexpression knockdown methods HB96, HN4 CAL27 lines were...
Metabolic skeletal disorders remain a major clinical challenge. The complexity of this disease requires strategy to address the net effects both inflammation and impaired bone formation. microRNA-based gene therapy provides several therapeutic advantages totackle these issues. Herein, we describe microRNA-21 (miR-21) delivery system with an additional effect from that carrier itself. Poly (salicylic acid) (PSA) is, for first time, synthesized viapolycondensation salicylic acid (SA),...
Abstract Objectives: This study aims to investigate different treatments on new bone formation around immediate implants in the canine posterior mandible with varying sized mesial-distal gap. Materials and methods: The 4 th premolar 1 st molar of six Labrador dogs were extracted from mandible, dental placed mm below level buccal crest. Moderate/large gaps between sockets treated one four methods divided into following groups: (1) blank group, (2) collagen membrane (CM) (3) deproteinized...