A5101478358- Genetic Mapping and Diversity in Plants and Animals
- Plant Stress Responses and Tolerance
- Plant Disease Resistance and Genetics
- Photosynthetic Processes and Mechanisms
- Plant Molecular Biology Research
- Plant Pathogens and Resistance
- Cancer-related molecular mechanisms research
- Genetics and Plant Breeding
- ATP Synthase and ATPases Research
- Plant Gene Expression Analysis
- Plant-Microbe Interactions and Immunity
- Ion Transport and Channel Regulation
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Wheat and Barley Genetics and Pathology
- Plant Genetic and Mutation Studies
- biodegradable polymer synthesis and properties
- Advanced Software Engineering Methodologies
- Service-Oriented Architecture and Web Services
- GABA and Rice Research
- Mitochondrial Function and Pathology
- Plant tissue culture and regeneration
- Pesticide Exposure and Toxicity
- Software System Performance and Reliability
- Genomics and Phylogenetic Studies
Yunnan Academy of Agricultural Sciences
2010-2025
Children's Hospital of Zhejiang University
2011-2025
Incyte (United States)
2016-2024
Wenzhou Medical University
2024
Tobacco Research Institute
2016-2024
Jiangxi Academy of Agricultural Sciences
2021-2024
Chinese Academy of Sciences
2021-2024
Chongqing Jiaotong University
2022-2024
Dian Diagnostics (China)
2024
Shantou University Medical College
2022-2024
Two components of the chloroplast envelope, Tic20 and Tic22, were previously identified as candidates for general protein import machinery by their ability to covalently cross-link nuclear-encoded preproteins trapped at an intermediate stage in across envelope (Kouranov, A., D.J. Schnell. 1997. J. Cell Biol. 139:1677–1685). We have determined primary structures Tic22 investigated localization association within envelope. is a 20-kD integral membrane component inner membrane. In contrast,...
Drought is one of the major abiotic stresses affecting plant growth, development and crop productivity. ABA responsive element binding factor (ABF) plays an important role in stress responses via regulating expression stress-responsive genes.In this study, a gene coding for ABF (PtrABF) was isolated from Poncirus trifoliata (L.) Raf. PtrABF had complete open reading frame 1347 bp, encoding 448 amino acid peptide, shared high sequence identities with ABFs other plants. subcellularly targeted...
Force-producing convergence (narrowing) and extension (lengthening) of tissues by active intercalation cells along the axis play a major role in axial morphogenesis during embryo development both vertebrates invertebrates, failure these processes human embryos leads to defects including spina bifida anencephaly. Here we use Xenopus laevis, system which polarized cell motility that drives this has been related forces close blastopore elongate body axis, examine myosin IIB extension. We find...
Ionic liquids (ILs) have been proven to be an effective technology for enhancing drug transdermal absorption. However, due the unique structural components of ILs, design efficient ILs and elucidation action mechanisms remain explored. In this review, basic principles ideal delivery system (TDDS) are discussed considering melting point, skin permeability, toxicity, which depend on molar ratios, types, functional groups ions inter-ionic interactions. Secondly, contributions development TDDS...
By tethering intermediate filaments (IFs) to sites of intercellular adhesion, desmosomes facilitate formation a supercellular scaffold that imparts mechanical strength tissue. However, the role IF–membrane attachments play in strengthening adhesion has not been directly examined. To address this question, we generated Tet-On A431 cells inducibly expressing desmoplakin (DP) mutant lacking rod and IF-binding domains (DPNTP). DPNTP localized plasma membrane led dissociation IFs from junctional...
The import of nucleus-encoded preproteins into plastids requires the coordinated activities membrane protein complexes that facilitate translocation polypeptides across envelope double membrane. Tic20 was identified previously as a component machinery inner by covalent cross-linking studies with trapped preprotein intermediates. To investigate role in import, we altered expression Arabidopsis ortholog (atTic20) antisense expression. Several lines exhibited pronounced chloroplast defects...
Little is known about how protocadherins function in cell adhesion and tissue development. Paraxial protocadherin (PAPC) controls sorting morphogenetic movements the Xenopus laevis embryo. We find that PAPC mediates these functions by down-regulating activity of C-cadherin. Expression exogenous C-cadherin reverses PAPC-induced gastrulation defects. Moreover, loss endogenous results elevated dorsal mesoderm interferes with normal blastopore closure, a defect can be rescued dominant-negative...
Abscisic acid (ABA) is an important phytohormone for plant growth, development and responding to stresses such as drought, salinity, pathogen infection. Pyrabactin Resistance 1 (PYR1)/PYR1-Like (PYL)/Regulatory Component of ABA Receptor (RCAR) (hereafter referred PYLs) has been identified the receptors. The PYL family members have well studied in many plants. However, not systematically at genome level cultivated tobacco (Nicotiana tabacum) its two ancestors. In this study, phylogenic...
The development of the concept "sharing" in era digital economy has promoted significant changes innovation mechanism tourism industry. This article takes 31 provinces (municipalities and districts) China as research object, collect four types statistics. Inspired by resource-based theory dynamic capability theory, builds a model resource sharing for industry innovation, proposes relevant hypotheses, discusses influence uses fixed effects intermediary empirical test. results show that...
Abstract Two integral outer envelope GTPases, Toc34 and Toc86, are proposed to regulate the recognition translocation of nuclear-encoded preproteins during early stages protein import into chloroplasts. Defining precise roles Toc86 has been complicated by inability distinguish their GTPase activities. Furthermore, assignment function is rendered equivocal recent reports suggesting that standard protocol for isolation chloroplasts results in significant proteolysis (B. Bolter, T. May, J. Soll...
The arginase inhibitor INCB001158 was evaluated for safety (primary endpoint) in locally advanced or metastatic solid tumours; pharmacokinetics, pharmacodynamics and efficacy were also assessed. In this non-randomised, open-label, three-part phase 1 study, orally administered two times per day as monotherapy combination with intravenous pembrolizumab 200 mg every 3 weeks. Dose expansion conducted tumour-type cohorts (with without prior anti-PD-1/PD-L1 (programmed death protein 1/programmed...
Impacts of red blood cell (RBC) suspension storage on outcomes in pediatric patients receiving RBC transfusions remains uncertain. Therefore, our objective is to examine the association between duration and patients. A retrospective study was conducted 222 admitted medical surgical departments at center 2021. Primary assessed were 28-day mortality length hospital stays, while secondary included transfusion-related complications, total volume transfusions, number interval transfusions....
Background Paraxial protocadherin (PAPC) and fibronectin leucine-rich domain transmembrane protein-3 (FLRT3) are induced by TGFβ signaling in Xenopus embryos both regulate morphogenesis inhibiting C-cadherin mediated cell adhesion. Principal Findings We have investigated the functional physical relationships between PAPC, FLRT3, C-cadherin. Although neither PAPC nor FLRT3 required for each other to adhesion, they do interact functionally physically, form a complex with cadherins. By itself...
MADS-box genes play a pivotal role in various processes, including floral and seed development, controlling flowering time, regulation of fruits ripening, respond to abiotic biotic stressors planta. Tobacco (Nicotiana tabacum) has been widely used as model plant for analyzing the gene function, however, there less information on flowering, associated genes. In present study, total 168 NtMADS-box were identified from tobacco, their phylogenetic relationship, chromosome locations, structures...