A5032913708- Mesenchymal stem cell research
- Temporomandibular Joint Disorders
- Extracellular vesicles in disease
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Salivary Gland Disorders and Functions
- Oral and Maxillofacial Pathology
- Congenital Heart Disease Studies
- Periodontal Regeneration and Treatments
- Streptococcal Infections and Treatments
- Ferroptosis and cancer prognosis
- Congenital heart defects research
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- dental development and anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Bone and Joint Diseases
- Bone Tissue Engineering Materials
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Systemic Lupus Erythematosus Research
- Otolaryngology and Infectious Diseases
- Dental Radiography and Imaging
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2015-2025
Zhongshan Hospital
2025
Fudan University
2025
Lanzhou University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
National Clinical Research
2018-2024
Shanghai Stomatological Hospital
2009-2024
Lanzhou University Second Hospital
2024
Harvard University
2024
On-demand controlled miR-21-5p delivery system integrates immune modification and proangiogenesis assists MI therapy.
Functional reconstruction of maxillofacial bone defects is a considerable clinical challenge. Many studies have emphasized the osteogenic and angiopoietic abilities stem cells for tissue regeneration. We previously showed that microRNA-21 (miRNA-21) can promote angiogenesis in human umbilical cord blood-derived mesenchymal (UCBMSCs). In present study, role miRNA-21 differentiation marrow-derived (BMSCs) was investigated. Western blotting qPCR were performed to investigate influences on...
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic oxidative stress is an important factor contributes to the postmenopausal osteoporosis (PMOP). Mitochondrial quality control takes a pivotal role in regulating and cell senescence. Genistein major isoflavone soy products, which best known for its ability inhibit loss both women ovariectomized (OVX) rodents. Here we show that OVX-BMMSCs displayed premature senescence, elevated reactive oxygen species (ROS) level...
Breast cancer metastases to bone poses a significant challenge for the administration of treatment strategies. The microenvironment, metastatic tumor cells, osteoclasts, and tumor-associated macrophages (TAMs) all play crucial synergistic roles in creating favorable environment proliferation, progression, survival tumor, which turn induces osteoclast-mediated destruction. In this study, we functionalized immunostimulatory cytosine-phosphate-guanosine (CpG)-loaded metal-organic framework...
Periodontitis is an immune inflammatory disease that leads to progressive destruction of bone and connective tissue, accompanied by the dysfunction even loss periodontal ligament stem cells (PDLSCs). Pyroptosis mediated gasdermin-D (GSDMD) participates in pathogenesis diseases. However, whether pyroptosis mediates PDLSC loss, inflammation triggered involved pathological progression periodontitis remain unclear. Here, we found PDLSCs suffered GSDMD-dependent release interleukin-1β (IL-1β)...
Crosstalk between nerves and bone is essential for repair, which Schwann cells (SCs) are crucial in the regulation of microenvironment. Considering that exosomes critical paracrine mediators intercellular communication exert important effects tissue aim this study to confirm function molecular mechanisms cell-derived (SC-exos) on regeneration propose engineered constructs simulate SC-mediated nerve–bone crosstalk. SCs promoted proliferation differentiation marrow mesenchymal stem (BMSCs)...
Mesenchymal stem cells (MSCs) have become promising candidates for regeneration medicine due to their multidifferentiation potential and immunomodulatory ability. Compared with classic MSCs derived from the bone marrow fat, dental-derived show high plasticity, accessibility, applicability. Therefore, they are considered alternative sources medicine. Four types of were isolated dental pulp, periodontal ligament, follicle, alveolar same donor, there five different individuals. We analyzed...
Abstract Sepsis poses a significant challenge in clinical management. Effective strategies targeting iron restriction, toxin neutralization, and inflammation regulation are crucial combating sepsis. However, comprehensive approach simultaneously these multiple processes has not been established. Here, an engineered apoptotic extracellular vesicles (apoEVs) derived from macrophages is developed their potential as multifunctional agents for sepsis treatment investigated. The extensive...
Abstract Senescence in bone marrow mesenchymal stem cells (BMSCs), triggered by excessive oxidative stress, plays a crucial role the onset of postmenopausal osteoporosis. Recent studies underscore importance mitochondrial rehabilitation and quality control as key determinants modulation stress cellular senescence. MitoTEMPO, mitochondria‐targeted antioxidant, has been shown to mitigate heightened levels reactive oxygen species (ROS). In our research, we observed that BMSCs from...
Abstract Temporomandibular joint osteoarthritis (TMJOA) is a commonly encountered degenerative disease in oral and maxillofacial surgery. Recent studies have shown that the excessive unbalanced activation of Wnt/β‐catenin signaling connected with pathogenesis TMJOA due to inability inhibit over‐activated Wnt pathway, while Wnt16‐deficient mice has more severe Knee OA. However, efficacy direct intra‐TMJ injection Wnt16 for relief still not directly confirmed. Moreover, small‐molecule drugs...
Fibroblasts can regulate tumour development by secreting various factors. For COAD survival prediction and CAFs-based treatment recommendations, it is critical to comprehend the heterogeneity of CAFs find biomarkers. We identified fibroblast-associated specific marker genes in colon adenocarcinoma single-cell sequencing analysis. A fibroblasts-related gene signature was developed, patients were classified into high-risk low-risk cohorts based on median risk score. Additionally, impact these...
BACKGROUND Circulating tumor cell (CTC) count and neutrophil-to-lymphocyte ratio (NLR) are both closely associated with the prognosis of hepatocellular carcinoma (HCC). AIM To investigate prognostic value combining these two indicators in HCC. METHODS Clinical data were collected from patients advanced HCC who received immune therapy combined targeted at Department Oncology, Affiliated Hospital Southwest Medical University, Sichuan, China, 2021 to 2023. The optimal cutoff values for CTC...
There is an urgent need for precise diagnosis to distinguish nontuberculous mycobacterial (NTM) diseases from pulmonary tuberculosis (PTB) and other respiratory diseases. The aim of this study evaluate the diagnostic performance Interferon-gamma (IFN-γ) release assays (IGRAs), including antigen-specific peripheral blood-based quantitative T cell assay (T-SPOT.TB) QuantiFERON-TB-Gold-Test (QFT-G), in differentiating NTM infections ( N = 1,407) culture-confirmed PTB 1,828) 2,652). At specie...