Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic oxidative stress is an important factor contributes to the postmenopausal osteoporosis (PMOP). Mitochondrial quality control takes a pivotal role in regulating and cell senescence. Genistein major isoflavone soy products, which best known for its ability inhibit loss both women ovariectomized (OVX) rodents. Here we show that OVX-BMMSCs displayed premature senescence, elevated reactive oxygen species (ROS) level...

Abstract Senescence in bone marrow mesenchymal stem cells (BMSCs), triggered by excessive oxidative stress, plays a crucial role the onset of postmenopausal osteoporosis. Recent studies underscore importance mitochondrial rehabilitation and quality control as key determinants modulation stress cellular senescence. MitoTEMPO, mitochondria‐targeted antioxidant, has been shown to mitigate heightened levels reactive oxygen species (ROS). In our research, we observed that BMSCs from...

Abstract Background Extraction of impacted mandibular third molar (M3) has been cited as causing osseous defect at the distal aspect adjacent second (M2). Purpose This randomized controlled trial was aimed to evaluate effect autogenous bone grafting in situ for regeneration periodontal M2 compared with non‐grafting after M3 removal. Materials and Methods A total 60 sites 51 adult patients were enrolled randomly assigned control group or test group. In both groups, extracted using a...

Repair of large bone defects remains a challenge for surgeons, tissue engineering represents promising approach. However, the use this technique is limited by delayed vascularization in central regions scaffold. Growth differentiation factor 15(GDF15) has recently been reported to be potential angiogenic cytokine and an ability promote proliferation human umbilical vein endothelial cells(HUVECs). Whether it can applied promoting vascularized regeneration still unknown. In study, we...

Selecting either buccal or lingual approach for the mandibular third molar surgical extraction has been an intense debate years. The aim of this observational retrospective study was to classify based on proximity external cortical bone, and analyze position inferior alveolar canal (IAC) each type. Cone-beam CT (CBCT) data 110 deeply impacted molars from 91 consecutive patients were analyzed. A new classification mean deduction value (MD) buccal-lingual bone thickness proposed: MD≥1 mm...

Abstract Stem cells play a crucial role in maintaining tissue regenerative capacity and homeostasis. However, mechanisms associated with stem cell senescence require further investigation. In this study, we conducted proteomic analysis of human dental pulp (HDPSCs) obtained from individuals various ages. Our findings showed that the expression NUP62 was decreased aged HDPSCs. We discovered alleviated senescence-associated phenotypes enhanced differentiation potential both vitro vivo....

Abstract Compound infantile hemangiomas (IHs) are problematic and usually require intervention. This retrospective study aimed to introduce a combined therapy of oral propranolol topical timolol evaluate its efficacy safety. Eighty-nine infants with compound IHs were treated 2 mg/kg/day divided times per day maleate 0.5% gel 3 day, for at least months. Two observers evaluated the hemangioma independently 0, 1, 3, 6, 9 months after initiation treatment. Changes in score values using paired t...

Treatment of microcystic lymphatic malformations (LMs) is still a great challenge to physicians in the field managing vascular anomalies. Several kinds treatment have been proposed for LMs, but responses these modalities vary considerably among individuals. The aim study was investigate safety and efficacy intralesional injection pingyangmycin LMs located deep facial region. Twenty-one consecutive patients with deep-seated were treated between March 2010 April 2015. received 2 8 injections,...

Abstract Background The extraction of impacted mandibular 3rd molar is highly related to bone defect distal the adjacent 2nd molar. Purpose aim this study was evaluate effect different grafting materials for treatment in canine model. Materials and Methods In 12 beagle dogs, bilateral molars were extracted entire mesial socket surgically removed. Twenty‐four defects (4 mm width 8 depth) randomly assigned 4 groups, grafted using 1 following protocols: (1) group C: no graft; (2) Ta: autogenous...

Analysis of adjacent tooth resistance is essential in wisdom teeth extraction to prevent trauma, however it lacks adequate attention nowadays. This study aims at suggesting special methods based on analysis for prevention damage. In this study, 136 complicated mandibular third molars extracted using piezosurgery were reviewed and classified the resistances shown orthopantomogram (OPG) during their mesio-distal rotations: degree I refers with no resistance; II released after mesial-half crown...

Linear (two-dimensional) and three-dimensional (3D) plating systems (Poly-Medics) composed of the resorbable copolymer polyglycolic acid (PGA) poly-I-lactic (PLLA) (Lactosorb) were studied in vitro. The plates applied to osteotomized fresh frozen human cadaveric metacarpal bones that then tested for torsional rigidity three-point bending strength rigidity. results compared those from another study two low-profile titanium (Leibinger Synthes). Analysis variance revealed linear-flat Lactosorb...

Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe adverse reaction, which results in progressive bone destruction maxillofacial region patients. To date, pathological mechanisms remain largely unclear. Recently, we found that BRONJ patient had significantly deep periodontal pockets and defects before exposed necrotic bone. Human ligament stem cells (hPDLSCs) play key roles physiological maintenance regeneration tissues. However, activities hPDLSCs derived from lesions role...

The aim of this study was to evaluate the effect and safety lingual split technique using piezosurgery for extraction positioned impacted mandibular 3rd molars with goal proposing a more minimally invasive choice common surgery. Eighty-nine consecutive patients 110 requiring were performed piezosurgery. One sagittal osteotomy line 2 transverse designed occlusal bone removal. success rate, operative time, postoperative outcome, major complications (including nerve injury, mandible fracture,...

Abstract To explore the potential network markers and related signaling pathways of human B cells infected by COVID-19, we performed standardized integration analysis single-cell sequencing data to construct conditional cell-specific networks (CCSN) for each cell. Then peripheral blood were clustered annotated based on degree matrix (CNDM) gene expression (GEM), respectively, selected further analysis. Besides, CNDM cells, hub genes ‘dark’ (a has a significant difference between case control...

Abstract Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a clinical condition that specifically occurs in oral cavity, characterized by retarded wound healing mucosa accelerating exposure bone. Moreover, pathological mechanism remains poorly understood. Gingival mesenchymal stem cells (GMSCs) play critical role gingival and soft tissue regeneration. Although previous studies have showed bisphosphonates (BPs) are highly toxic to healthy GMSC, there overall lack direct evidence...

Abstract Background Dentigerous cyst (DC) is a bone destructive disease and remains challenge for clinicians. Marsupialization enables the to regenerate with capsule maintaining, making it preferred therapeutic means DC adjacent vital anatomical structures. Given that capsules of are derived from odontogenic epithelium remnants at embryonic stage, we investigated whether there were mesenchymal stem cells (MSCs) located in role they played regeneration after marsupialization. Methods Samples...

Apex bending and torsional loading were utilized to study the effects of different plate design thickness, screw size on rigidity strength seven titanium mini- microplates placed onto osteotomized proximal phalanges. One hundred forty-four fresh frozen human cadaveric phalangeal bones underwent a mid shaft osteotomy followed by application one following plates: (1) Synthes linear 1.5-mm five-hole plates, (2) Leibinger 1.2-mm or (3) 1.7-mm four-hole (4) three-dimensional four-hole, (5)...

Abstract Objective This study aimed to investigate the risk factors associated with temporomandibular joint (TMJ) anterior disc displacement (ADD) in relation dental malocclusion. Methods In this cross-sectional study, a clinical examination was conducted on patients aged 11–35 years who visited TMJ and Orthodontic Clinic at hospital. Magnetic resonance imaging (MRI) of performed diagnose both ADD condylar resorption (CR). Occlusal measurements were obtained analyzed using 3D scanning...

Objective To explore the application of body position intervention combined pronase in gastric mucosal cleaning painless gastroscopy. Methods A total 200 patients who underwent gastroscopy from July 2016 to 2017 digestive endoscopy center were selected as subjects. According random digital table method, randomly divided into experimental group and control 100 cases. In group, before gastroscope was examined, plus Dimethicone Powder lidocaine mucilage used, then (right supine 5...

Abstract Background: Retarded gingival healing is the hallmark of bisphosphonate-related osteonecrosis jaw (BRONJ) and poses a great challenge to maxillofacial surgeons. Although previous studies have showed that bisphosphonates (BPs) are highly toxic healthy mesenchymal stem cells (GMSCs) in vitro, there overall lack direct evidence demonstrating regeneration capacity oral mucosa BRONJ patients. In present study, we aim isolate GMSCs from patients’ gingiva assessed their phenotypes...