A5100324253- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Ear and Head Tumors
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Tumors and Oncological Cases
- Oral microbiology and periodontitis research
- Gout, Hyperuricemia, Uric Acid
- Inflammasome and immune disorders
- Anesthesia and Neurotoxicity Research
- Genetics, Aging, and Longevity in Model Organisms
- Autophagy in Disease and Therapy
- Axon Guidance and Neuronal Signaling
- Osteomyelitis and Bone Disorders Research
Medical University of South Carolina
2022-2025
Chengdu Third People's Hospital
2025
Southwest Jiaotong University
2025
Shanghai Ninth People's Hospital
2009-2024
Shanghai Jiao Tong University
2009-2024
First Affiliated Hospital of Bengbu Medical College
2024
Nanjing Medical University
2022
Jiangsu Province Hospital
2022
Jinan University
2022
National Clinical Research Center for Digestive Diseases
2021-2022
Background/Aims: The lncRNA Homeobox (HOX) transcript antisense RNA (HOTAIR) is overexpressed in numerous cancers. HuR also during tumourigenesis and abnormally present within the cytoplasm, where it binds to AU-rich elements 3′UTRs of target mRNA post-transcriptionally regulates expression its genes. However, whether HOTAIR regulated mechanisms by which affects head neck squamous cell carcinoma (HNSCC) are not well understood. Methods: MTT, cycle arrest apoptotic assays were used examine...
Abstract Oral squamous cell carcinoma (OSCC) is a common public health problem worldwide with poor prognosis, which largely due to lymph node metastasis and recurrence. Identification of specific molecular markers OSCC would be very important for early diagnosis. In this study, we screened the potential prognosis via unbiased transcriptomic microarray analysis in paired two lines, metastatic HN12 line low parental HN4 line. The results showed that vimentin, 87-fold increase expression, was...
Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor with poor clinical outcomes due to recurrence, metastasis, treatment resistance. Cancer stem cells (CSCs), small population among cells, are proposed be responsible for initiation, progression, drug resistance, recurrence. Here we show that high LSD1 expression was predictor of prognosis HNSCC patients. We found essential the maintenance CSC properties by regulating Bmi-1 expression. Moreover, ablation...
Abstract Background Sepsis-associated encephalopathy (SAE) often results from neuroinflammation. Recent studies have shown that brain platelet-derived growth factor receptor β (PDGFRβ) cells, including pericytes, may act as early sensors of infection by secreting monocyte chemoattractant protein-1 (MCP-1), which transmits inflammatory signals to the central nervous system. The erythroblast transformation-specific (ETS) transcription Friend leukemia virus integration 1 (Fli-1) plays a...
// Shuli Liu 1, * , Dongxia Ye Dongliang Xu 2, 3 Yueling Liao Ling Zhang 1 Wenwen Yu Yanan Wang Yue He Jingzhou Hu Wenzheng Guo 2 Tong Beibei Sun 4 Hongyong Song Huijing Yin Jingyi 5 Yadi Wu Hanguang Zhu Binhua P. Zhou Jiong Deng 3, Zhiyuan Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People’s Hospital, Shanghai Jiao University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...
Sepsis-associated encephalopathy (SAE) is characterized by acute and diffuse brain dysfunction correlates with long-term cognitive impairments no targeted therapy. We used a mouse model of sepsis-related impairment to examine the role lncRNA nuclear enriched abundant transcript 1 (Neat1) in SAE. observed that Neat1 expression was increased neuronal cells from septic mice it directly interacts hemoglobin subunit beta (Hbb), preventing its degradation. The Neat1/Hbb axis suppressed...
SEMA7A belongs to the Semaphorin family and is involved in oncogenesis tumor progression. Aberrant glycosylation has been intricately linked with immune escape growth. a highly glycosylated protein five sites. The underlying mechanisms of its contribution immunosuppression tumorigenesis are unclear. Here, we identify overexpression aberrant N-glycosylation head neck squamous cell carcinoma, elucidate fucosyltransferase FUT8 catalyzes core fucosylation at N-linked oligosaccharides (Asn 105,...
Abstract Pyroptosis is associated with various cardiovascular diseases. Increasing evidence suggests that long noncoding RNAs (lncRNAs) have been implicated in gene regulation, but how lncRNAs participate the regulation of pyroptosis heart remains largely unknown. In this study, we aimed to explore antipyroptotic effects lncRNA FGF9‐associated factor (FAF) acute myocardial infarction (AMI). The expression patterns FAF, miR‐185‐5p and P21 activated kinase 2 (PAK2) were detected...
J Oral Pathol Med (2013) 42 : 140–147 Background: The carcinogenesis mechanism of adenoid cystic carcinoma (ACC) the salivary gland is poorly understood. MicroRNA155 (miRNA155) has been involved in many malignant tumors. present study aims to examine role miRNA155 tumor growth and invasion ACC. Methods: MiRNA155 expression was determined ACC specimens along with normal glands by quantitative PCR. Using ACC‐2 cells as a model for ACC, cell proliferation examined MTT assay after knocking down...
miR-139-5p has a tumor suppressor effect in some cancers and negatively regulates CXCR4. To this end, we examined the expression mechanism of action CXCR4 oral squamous cell carcinoma (OSCC). miRNA-139-5p was down-regulated whereas increased tissues cells OSCC. Moreover, low associated with survival. Overexpression OSCC inhibited vitro vivo proliferation mobility WNT responsive c-myc, cyclinD1, Bcl-2, such effects were all reversible by an inhibitor or over-expression The inverse relation...
Oral squamous cell carcinoma (OSCC) is a common head and neck cancer, the incidence of OSCC increasing. As mortality keeps increasing, it crucial to clarify its pathogenesis develop new therapeutic strategies.Confocal laser scanning microscopy was used evaluate uptake nanoparticles (NPs). The potential functions USP30 were evaluated by counting kit (CCK)-8, flow cytometry, biochemical assay, coimmunoprecipitation, qRT-PCR, immunoblotting. antitumor effect NP-loaded inhibitor MF-094 in vitro...
To study the role of LncRNA CASC15 in oral squamous cell carcinoma.In present study, we showed that plasma was up-regulated stage I and II carcinoma patients than ulcer healthy controls, while no significant correlation found between controls. Up-regulation distinguished from MEG3 inversely correlated with tissues. In cells, over-expression led to inhibited expression MEG3, did not alter expression. decreased, increased proliferation rate cells. addition, attenuated effects...
Programmed death-ligand 1 (PD-L1) expression has been approved as an immune checkpoint inhibitor (ICI) response predictive biomarker; however, the clinicopathological and molecular features of HPV-positive oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] based on PD-L1 are not well studied. We aimed to characterize clinicopathological, tumor microenvironmental, HPV(+)OPSCC with different scored by combined positive score (CPS). A total 112 cases were collected from 2008-2021 received CD8...
Aging is a natural process in which the structural integrity of an organism declines over time.
Background This study aimed to explore the relationship between nucleophosmin ( NPM 1) and patient clinical characteristics. Moreover, we investigated effect of 1 in tumor proliferation apoptosis salivary gland adenoid cystic carcinoma SACC ). Materials methods expression was examined 74 specimens 31 non‐cancerous epithelium adjacent NCEAC ) by immunohistochemistry IHC RNA interference technology used silence cells. We transwell culture assay, cell counting kit‐8 tests, colony formation...
Lately, long non-coding RNA (lncRNA) is recognized as a key regulator of gastric cancer (GC) which has aroused great interest in the fields medicine, toxicology, and functional food. Studies related to LncRNA expression microarray data indicate that BX357664 down-regulated GC specimens. However, pattern molecular mechanism have not been studied so far. The purpose this study was investigate lncRNA its function cell lines. Real-time quantitative polymerase chain reaction (RT-qPCR) used detect...
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition with significant public health implications that arise following exposure to traumatic events. Recent studies highlight the involvement of immune dysregulation in PTSD, characterized by elevated inflammatory markers. However, precise mechanisms underlying this imbalance remain unclear. Previous research has implicated friend leukemia virus integration 1 (FLI1), an erythroblast transformation-specific (ETS)...
ABSTRACT Objectives Porphyromonas gingivalis ( P. ) is a keystone periodontal pathogen associated with various gastro‐intestinal tract cancers. However, whether can promote oral squamous cell carcinoma (OSCC) and the underlying mechanism such promotion remain unclear. Materials Methods In this study, OSCC xenograft models were used to evaluate effects of on tumor progression. The functional studies done several lines in vitro. ‐specific 16S rRNA fluorescent situ hybridization (FISH) was test...
In this study, we evaluated the effects of marsupialization in treating unicystic ameloblastoma (UA) and investigated relationship between TP53 interleukin 1 α (IL-1α) expression clinical outcome UA treated with marsupialization. Consecutive patients curettage at Shanghai Ninth People's Hospital were included. According to unified standard, 48 included study. Of these, 20 showed a good response, 10 partial 18 no based on procedure. The proteins IL-1α was detected immunohistochemistry (IHC)....
We conducted a retrospective study to evaluate the relationship between external auditory canal (EAC) anomaly, temporal bone abnormality, and hearing levels using objective scoring systems in Chinese patients with microtia. The population consisted of 106 ears 94 (67 male 27 female) aged 5 45 years (mean: 12.6) EAC abnormalities were classified into 4 types according Schuknecht's criteria: type A, B, C, D. Developmental anomalies evaluated by Jahrsdoerfer computed tomography (CT) system...
To identify potential biomarkers of lingual cancer, 75 female C57BL/6J mice were subjected to 16-week oral delivery 4-nitroquinoline-1-oxide (4NQO; 50 mg/L), with 10 used as controls. Lingual mucosa samples representative normal tissue (week 0) and early 12) advanced 28) tumorigenesis harvested for microarray methylated DNA immunoprecipitation sequencing (MeDIP-Seq). Combined analysis Short Time-series Expression Miner (STEM), the Cytoscape plugin cytoHubba, screening differentially...