A5079568509- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Vascular Malformations and Hemangiomas
- Ear and Head Tumors
- RNA modifications and cancer
- Signaling Pathways in Disease
- Tumors and Oncological Cases
- Peptidase Inhibition and Analysis
- Reconstructive Facial Surgery Techniques
- Bone Tumor Diagnosis and Treatments
- Oral health in cancer treatment
- RNA Research and Splicing
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- Galectins and Cancer Biology
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
The People's Hospital of Guangxi Zhuang Autonomous Region
2025
Sun Yat-sen Memorial Hospital
2015-2024
Sun Yat-sen University
2015-2024
Luoyang Institute of Science and Technology
2024
Southeast University
2024
Guangxi Medical University
2024
First Affiliated Hospital of GuangXi Medical University
2024
Takeda (United States)
2018
Deerfield (United States)
2018
Marymount University
2014-2015
J Oral Pathol Med (2011) 40: 545–551 Background: Tumor budding is a readily detectable histopathological feature and has been recognized as an adverse prognostic factor in several human cancers. However, the value of tumor tongue squamous cell carcinoma (TSCC) not reported. The purpose this study was to assess correlation with clinicopathologic features, known molecular biomarkers (E-cadherin Vimentin), well evaluate its significance for TSCC. Methods: Archival clinical samples 230 patients...
Abstract Chemoresistance is a major cause of cancer progression and the mortality patients. Developing safe strategy for enhancing chemosensitivity challenge biomedical science. Recent studies have suggested that vitamin D supplementation may decrease risk many cancers. However, role in chemotherapy remains unknown. We found sensitised oral cells to cisplatin partially reversed resistance. Using RNA-seq, we discovered lipocalin 2 (LCN2) an important mediator. Cisplatin enhanced expression...
Hepatocellular carcinoma (HCC) is a global health concern, ranking as the fourth leading cause of cancer-related deaths worldwide. However, role piwi-interacting RNAs (piRNAs) in HCC processes has not been extensively explored. Through small RNA sequencing, our study identified specific piRNA, pir-hsa-216911, which highly expressed cells. This overexpression pir-hsa-216911 promotes cell invasion and inhibits death, particularly pyroptosis. Knocking out led to increased pyroptosis activity,...
A correction to this paper has been published and can be accessed via a link at the top of paper.
Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP allow reconstruction the key molecular steps involved these two non-apoptotic cell death pathways by harnessing power light. Further, use LiPOPs coupled upconversion nanoparticles or bioluminescence demonstrated to achieve wireless chemo-optogenetic killing cancer multiple mouse tumor models. can trigger necroptotic...
Abstract In the context of cancer therapy, a recently identified therapeutic target is represented by essential subtype RNA transcripts ‐ long noncoding RNAs (lncRNA). While this case, it especially difficult to successfully regulate expression in vivo, particularly due protection granted nuclear envelope lncRNAs. This study documents development nucleus‐specific interference (RNAi) nanoparticle (NP) platform for targeted regulation lncRNA function, order effectuate successful therapy. An...
Abstract Background EGFR is an important signal involved in tumor growth that can induce metastasis and drug resistance. Exploring targets for effective regulation topic current research development. Inhibiting effectively inhibit the progression lymph node of oral squamous cell carcinoma (OSCC) because OSCC a type cancer with high expression. However, problem resistance particularly prominent, identifying new target could reveal strategy. Methods We sequenced wild or EGFR-resistant cells...
The aim of the present study was to investigate expression and function metastasis-associated in colon cancer 1 (MACC1) tongue squamous cell carcinoma (TSCC) its relationship with extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147). Levels MACC1 EMMPRIN were analyzed 65 paraffin‑embedded tissue specimens TSCC adjacent non-cancerous tissues using immunohistochemistry (IHC). highly associated lymphatic metastasis expression. Overexpression significantly correlated poor overall...
In this study, we use machine learning techniques to develop an efficient preoperative magnetic resonance imaging (MRI) radiomics approach for evaluation of cervical lymph node (CLN) status.After collecting all patients' MRI images, used CLN radiomic features, the apparent diffusion coefficients (ADC) from diffusion-weighted (DWI), and short diameter build model predict status CLN.One hundred twenty cases met inclusion criteria. The including ADC, size achieved better performance prediction...
GSDMD is the key effector of pyroptosis, but its non-pyroptosis-related functions have seldom been reported. Here, we report that overexpressed in different types tumours, including head and neck squamous-cell carcinoma, it promotes sensitivity tumour cells to cisplatin. Unexpectedly, enhanced cisplatin mediated by apoptosis not well-known function GSDMD. Furthermore, found can activate unfolded protein response promoting phosphorylation eIF2α. Mechanistically, demonstrated directly bind...
Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis investigate potential molecular mediators HNSCC chemoresistance, we identified SERPINB2, a known inhibitor extracellular serine proteinase urokinase-type plasminogen activator (uPA), as an important candidate. Whereas SERPINB2 function suppressor uPA cascades, many which play roles in tumor invasion...
Head and neck cancer is the sixth most common in world of them are squamous cell carcinomas. High frequency cisplatin resistance head carcinoma ( HNSCC ) leads to tumor relapse irresponsiveness cisplatin‐based chemotherapy. However, mechanisms underlying still largely unrevealed. In this study, we found that CD 147 was overexpressed cisplatin‐resistant lines. Based on result, expression down‐regulated line observed sensitivity increased, as showed results MTT assay PI ‐staining apoptotic...