A5087273879- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Supramolecular Self-Assembly in Materials
- Immune cells in cancer
- Hydrogels: synthesis, properties, applications
- RNA Research and Splicing
- Catalysis and Hydrodesulfurization Studies
- Circular RNAs in diseases
- Catalysis and Oxidation Reactions
- Catalysts for Methane Reforming
- Advanced Nanomaterials in Catalysis
- Catalytic Processes in Materials Science
- Synthetic Organic Chemistry Methods
- Cancer, Lipids, and Metabolism
- Autophagy in Disease and Therapy
- Dendrimers and Hyperbranched Polymers
- Polydiacetylene-based materials and applications
- Liver Disease Diagnosis and Treatment
- Polymer Surface Interaction Studies
Sun Yat-sen Memorial Hospital
2018-2025
Sun Yat-sen University
2018-2025
Shanghai Institute of Materia Medica
2021-2024
Chinese Academy of Sciences
2021-2024
Nanjing University of Chinese Medicine
2023-2024
University of South China
2021-2024
Shanghai Electric (China)
2024
University of Chinese Academy of Sciences
2021-2023
Ruijin Hospital
2023
Harvard University
2015-2020
Abstract Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)‐based photothermal agents (PTAs) with satisfactory conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, new generation of PTAs based on two‐dimensional (2D) antimonene quantum dots (AMQDs) was developed by novel liquid exfoliation method. Surface modification AMQDs polyethylene glycol (PEG) significantly enhanced both stability in...
A critical literature analysis was conducted on the viable usage of CO2 in framework attempts to reduce emissions into atmosphere from various processes or rate increase concentration atmosphere. Applications based physical properties are summarized first. Major examples applications supercritical extraction, enhanced oil recovery, and use as inert gas fire extinguishing safety application industry. The possibilities chemical systematically discussed. can react with several hydrocarbons...
The application of nanoparticles (NPs) to drug delivery has led the development novel nanotherapeutics for treatment various diseases including cancer. However, clinical use NP-mediated not always translated into improved survival cancer patients, in part due suboptimal properties NP platforms, such as premature leakage during preparation, storage, or blood circulation, lack active targeting tumor tissue and cells, poor penetration. Herein, an innovative reactive oxygen species...
Abstract RNA interference (RNAi) gene silencing technologies have shown significant potential for treating various diseases, including cancer. However, clinical success in cancer therapy remains elusive, mainly owing to suboptimal vivo delivery of RNAi therapeutics such as small (siRNA) tumors. Herein, we developed a library polymers that respond narrow pH change (ultra‐pH‐responsive), and demonstrated the utility these materials targeted deep tumor‐penetrating nanoparticle (NP) RNAi. The...
Emerging two-dimensional (2D) nanomaterials, such as transition-metal dichalcogenide (TMD) nanosheets (NSs), have shown tremendous potential for use in a wide variety of fields including cancer nanomedicine. The interaction nanomaterials with biosystems is critical importance their safe and efficient application. However, cellular-level understanding the nano-bio interactions these emerging 2D (i.e., intracellular mechanisms) remains elusive. Here we chose molybdenum disulfide (MoS2) NSs...
With the capability of specific silencing target gene expression, RNA interference (RNAi) technology is emerging as a promising therapeutic modality for treatment cancer and other diseases. One key challenge clinical applications RNAi safe effective delivery agents such small interfering (siRNA) to particular nonliver diseased tissue (e.g., tumor) cell type with sufficient cytosolic transport. In this work, we proposed multifunctional envelope-type nanoparticle (NP) platform prostate...
Abstract Selective tumor targeting and drug delivery are critical for cancer treatment. Stimulus‐sensitive nanoparticle (NP) systems have been designed to specifically respond significant abnormalities in the microenvironment, which could dramatically improve therapeutic performance terms of enhanced efficiency, targetability, reduced side‐effects. We report development a novel L ‐cysteine‐based poly (disulfide amide) (Cys‐PDSA) family fabricating redox‐triggered NPs, with high hydrophobic...
Abstract Resistance development to one chemotherapeutic reagent leads frequently acquired tolerance other compounds, limiting the therapeutic options for cancer treatment. Herein, we find that overexpression of Rac1 is associated with multi-drug resistance neoadjuvant chemotherapy (NAC). Mechanistically, activates aldolase A and ERK signaling which up-regulates glycolysis especially non-oxidative pentose phosphate pathway (PPP). This increased nucleotides metabolism protects breast cells...
Supramolecular hydrogels self-assembled by α-cyclodextrin and methoxypolyethylene glycol−poly(caprolactone)-(dodecanedioic acid)-poly(caprolactone)−methoxypolyethylene glycol (MPEG-PCL-MPEG) triblock polymers were prepared characterized in vitro vivo. The sustained release of dextran-fluorescein isothiocyanate (FITC) from the lasted for more than 1 month, which indicated that promising controlled drug delivery. ECV304 cells marrow mesenchymal stem (MSC) encapsulated cultured hydrogels,...
Abstract Purpose: Malignant phyllodes tumor (PT) is a fast-progression neoplasm derived from periductal stromal cells of the breast, which currently still lack effective treatment strategies. Our previous studies showed that high density tumor-associated macrophages (TAM) plays an important role in malignant progression PTs. TAMs secreted large amount CCL18 to promote myofibroblast differentiation and invasion via binding its receptor PIPTNM3 on myofibroblasts. Herein, we investigate...
While RNA interference (RNAi) therapy has demonstrated significant potential for cancer treatment, the effective and safe systemic delivery of RNAi agents such as small interfering (siRNA) into tumor cells in vivo remains challenging. We herein reported a unique multistaged siRNA nanoparticle (NP) platform, which is comprised (i) polyethylene glycol (PEG) surface shell, (ii) sharp microenvironment (TME) pH-responsive polymer that forms NP core, (iii) charge-mediated complexes cell-targeting-...
Nanoparticles (NPs) formulated with cationic lipids and/or polymers have shown substantial potential for systemic delivery of RNA therapeutics such as small interfering (siRNA) the treatment cancer and other diseases. While both demonstrated promise to facilitate siRNA encapsulation endosomal escape, they could also hamper cytosolic release due charge interaction induce toxicities. Herein, a unique polymer–prodrug hybrid NP platform was developed multistage combination therapy. This system...
Rationale: The forkhead box A1 (FOXA1) is a crucial transcription factor in initiation and development of breast, lung prostate cancer. Previous studies about the FOXA1 transcriptional network were mainly focused on protein-coding genes. Its regulatory long non-coding RNAs (lncRNAs) their role oncogenic activity remains unknown. Methods: Cancer Genome Atlas (TCGA) data, RNA-seq ChIP-seq data used to analyze regulated lncRNAs. RT-qPCR was detect expression DSCAM-AS1, Western blotting...
Abstract Biodegradable polymeric nanoparticles (NPs) have demonstrated significant potential to improve the systemic delivery of RNA interference (RNAi) therapeutics, such as small interfering (siRNA), for cancer therapy. However, slow and inefficient siRNA release inside tumor cells generally observed most biodegradable NPs may result in compromised gene silencing efficacy. Herein, a redox‐responsive NP platform, composed solid poly(disulfide amide) (PDSA)/cationic lipid core...
Abstract Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)‐based photothermal agents (PTAs) with satisfactory conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, new generation of PTAs based on two‐dimensional (2D) antimonene quantum dots (AMQDs) was developed by novel liquid exfoliation method. Surface modification AMQDs polyethylene glycol (PEG) significantly enhanced both stability in...
Clinical success of cancer radiotherapy is usually impeded by a combination two factors, i.e., insufficient DNA damage and rapid repair during after treatment, respectively. Existing strategies for optimizing the radiotherapeutic efficacy often focus on only one facet issue, which may fail to function in long term trials. Herein, we report DNA-dual-targeting approach enhanced using hierarchical multiplexing nanodroplet, can simultaneously promote lesion formation prevent subsequent repair....
In this paper, an activable cell-penetrating peptide (CR8G3PK6, ACPP) with a shielding group of 2,3-dimethylmaleic anhydride (DMA) was conjugated antitumor drug doxorubicin (DOX) to construct novel prodrug (DOX-ACPP-DMA) for tumor targeted delivery. The DMA linked the primary amines K6 through amide bond used block function polycationic CPP (R8) intramolecular electrostatic attraction at physiological pH 7.4. At extracellular 6.8, hydrolysis led charge reversal, activating pristine improved...
Abstract Resistance to radiotherapy is frequently encountered in clinic, leading poor prognosis of cancer patients. Long noncoding RNAs (lncRNAs) play important roles the development radioresistance due their functions regulating expression target genes at both transcriptional and posttranscriptional levels. Exploring key lncRNAs elucidating mechanisms contributing are crucial for effective strategies reverse radioresistance, which however remains challenging. Here, actin filament‐associated...
Effectively activating macrophages that can engulf cancer cells is a promising immunotherapeutic strategy but remains major challenge due to the expression of "self" signals (e.g., CD47 molecules) by tumor prevent phagocytosis. Herein, we explored siRNA-assisted assembly for simultaneous delivery siRNA and mitoxantrone hydrochloride (MTO·2HCl) via PLGA-based nanoparticles. The suppressed signal silencing gene, while MTO induced surface exposure calreticulin (CRT) provide an "eat-me" signal....
Abstract Emerging evidence has demonstrated the significant contribution of mitochondrial metabolism dysfunction to promote cancer development and progression. Aberrant expression genome (mtDNA)‐encoded proteins widely involves dysfunction, targeted regulation their can be an effective strategy for therapy, which however is challenged due protection by double membrane. Herein, a mitochondria‐targeted RNAi nanoparticle (NP) platform breast (BCa) therapy developed. This nanoplatform composed...