Selectively cuting off the nutrient supply and metabolism pathways of cancer cells would be a promising approach to improve efficiency treatment. Here, targeted cascade bioreactor (designated as mCGP) was constructed for synergistic starvation photodynamic therapy (PDT) by embedding glucose oxidase (GOx) catalase in cell membrane-camouflaged porphyrin metal-organic framework (MOF) PCN-224 (PCN stands porous coordination network). Due biomimetic surface functionalization, immune escape...

The ultimate goal in cancer therapy and diagnosis is to achieve highly specific targeting cells. Coated with the source cell membrane specifically derived from homologous tumors, nanoparticles are identified self-recognition internalization by lines vitro tumor-selective "homing" tumor vivo even competition of another heterologous tumor. As result, MNP@DOX@CCCM nanovehicle showed strong potency for treatment MR imaging. This bioinspired strategy shows great potential precise...

In this study, we developed a general method to decorate plasmonic gold nanorods (GNRs) with CD44-targeting functional polymer, containing hyaluronic acid (HA)-targeting moiety and small molecule Glut1 inhibitor of diclofenac (DC), obtain GNR/HA-DC. This nanosystem exhibited the superiority selectively sensitizing tumor cells for photothermal therapy (PTT) by inhibiting anaerobic glycolysis. Upon specifically targeting CD44, sequentially time-dependent DC release could be achieved trigger...

In this paper, a self‐delivery system PpIX‐PEG‐(KLAKLAK) 2 (designated as PPK) is fabricated to realize mitochondria‐targeted photodynamic tumor therapy. It found that the PPK exhibited high drug loading efficacy well novel capacity in generation of intracellular reactive oxygen species (ROS). This study also indicated photochemical internalization effect photosensitizer protoporphyrin IX (PpIX) under short time light irradiation improved cellular PPK. On contrary, could target subcellular...

Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO2 ) with O2 self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through short time irradiation, 1 activated by photosensitizer methylene blue (MB) can induce lipid peroxidation break liposome, and enlarge contact area CaO2 H2 O, resulting in accelerated production. Accelerated level further regulates...

Abstract Conventional photodynamic therapy (PDT) has limited applications in clinical cancer due to the insufficient O 2 supply, inefficient reactive oxygen species (ROS) generation, and low penetration depth of light. In this work, a multifunctional nanoplatform, upconversion nanoparticles (UCNPs)@TiO @MnO core/shell/sheet nanocomposites (UTMs), is designed constructed overcome these drawbacks by generating situ, amplifying content singlet ( 1 ) hydroxyl radical (•OH) via water‐splitting,...

A multifunctional prodrug, designated as TPP‐L‐GEM, is fabricated to realize image‐guided in situ tumor photodynamic therapy (PDT) with red light activatable chemotherapy. Gemcitabine conjugated a fluorescent photosensitizer, meso‐tetraphenylporphyrin (TPP), by reactive oxygen species cleavable thioketal linker. Under the irradiation of low‐energy light, TPP can generate singlet and damage cells therapy. Simultaneously, linkage be cleaved result cascaded gemcitabine release, causing...

To integrate treatments of photothermal therapy, photodynamic therapy (PDT), and chemotherapy, this study reports on a multifunctional nanocomposite based mesoporous silica‐coated gold nanorod for high‐performance oncotherapy. Gold core is used as the hyperthermal agent silica shell reservoir photosensitizer (Al(III) phthalocyanine chloride tetrasulfonic acid, AlPcS 4 ). The modified with β‐cyclodextrin (β‐CD) gatekeeper via redox‐cleavable Pt(IV) complex controlled drug release....

In this work, a matrix metalloproteinase (MMP)-triggered tumor targeted mesoporous silica nanoparticle (MSN) is designed to realize near-infrared (NIR) photothermal-responsive drug release and combined chemo/photothermal therapy. Indocyanine green (ICG) doxorubicin (DOX) are both loaded in the MSN modified with thermal-cleavable gatekeeper (Azo-CD), which can be decapped by ICG-generated hyperthermia under NIR illumination. A peptidic sequence containing short PEG chain, (MMP) substrate...

Here, a protein farnesyltransferase (PFTase)-driven plasma membrane (PM)-targeted chimeric peptide, PpIX-C6-PEG8-KKKKKKSKTKC-OMe (PCPK), was designed for PM-targeted photodynamic therapy (PM-PDT) and enhanced immunotherapy via tumor cell PM damage fast release of damage-associated molecular patterns (DAMPs). The targeting ability PCPK originates from the cellular K-Ras signaling, which occurs exclusively to drive corresponding proteins by PFTase. With conjugation photosensitizer...

The cell membrane is the most important protective barrier in living cells and targeted therapy may be a high‐performance therapeutic modality for tumor treatment. Here, novel charge reversible self‐delivery chimeric peptide C 16 –PRP–DMA developed long‐term photodynamic (PDT). self‐assembled nanoparticles can effectively target to by enhanced permeability retention effect without additional carriers. After undergoing reverse acidic microenvironment, inserts into with long time of more than...

Here, a tumor-targeted MnO2 motor nanosystem (designed as MG/HA) was constructed by the assembly of glucose oxidase (GOD), manganese dioxide (MnO2), and glycoprotein CD44-targeting polymer hyaluronic acid (HA) to elevate cancer-starving therapy efficacy in solid tumor. Upon specific uptake MG/HA CD44 overexpressed cancer cells, GOD catalyzed oxidation into gluconic hydrogen peroxide (H2O2) accompanying consumption oxygen (O2). Meanwhile, would react with H2O2 generate O2, which is turn...

Abstract During the last decade, peptide‐based nanomaterials are recognized as upcoming biomedical materials for tumor imaging and therapy. The rapid expansion of peptides peptide derivatives is almost owing to their excellent biocompatibility, diverse bioactivity, potential biodegradability, specific biological recognition ability, easy chemical modification characteristic. present review outlines development up now concerning design applications multifunctional nanomaterials, with an...

Poor tumor selectivity and short life span of reactive oxygen species (ROS) are two major challenges in photodynamic therapy (PDT). In this study, a self‐transformable pH‐driven membrane anchoring photosensitizer (pHMAPS) is used to realize tumor‐specific accumulation situ PDT on cell maximize the therapeutic potency. It found that pHMAPS was able form α‐helix structure under acidic condition (pH 6.5 or 5.5), while remain random coil at normal pH 7.4. This secondary switch enables successful...

In this paper, an activable cell-penetrating peptide (CR8G3PK6, ACPP) with a shielding group of 2,3-dimethylmaleic anhydride (DMA) was conjugated antitumor drug doxorubicin (DOX) to construct novel prodrug (DOX-ACPP-DMA) for tumor targeted delivery. The DMA linked the primary amines K6 through amide bond used block function polycationic CPP (R8) intramolecular electrostatic attraction at physiological pH 7.4. At extracellular 6.8, hydrolysis led charge reversal, activating pristine improved...

Abstract Multidrug resistance (MDR) remains one of the biggest obstacles in chemotherapy tumor mainly due to P‐glycoprotein (P‐gp)‐mediated drug efflux. Here, a transformable chimeric peptide is designed target and self‐assemble on cell membrane for encapsulating cells overcoming MDR. This (C 16 ‐K(TPE)‐GGGH‐GFLGK‐PEG 8 , denoted as CTGP) with cathepsin B‐responsive membrane‐targeting abilities can into nanomicelles further encapsulate therapeutic agent doxorubicin (termed CTGP@DOX). After...

The number of patients who benefit from acquired immunotherapy is limited. Stimulator interferon genes (STING) signal activation a significant component to enhance innate immunity, which has been used realize broad-spectrum immunotherapy. Here, M@P@HA nanoparticles, as STING amplifier, are constructed Briefly, when was targeted into tumor cells, the nanoparticles decomposed with Mn2+ and activated release protoporphyrin (PpIX). Under light irradiation, generated reactive oxygen species...

A novel cancer targeting and pH-responsive prodrug was successfully designed synthesized. This M-prodrug demonstrated to have real-time drug release monitoring capability based on the concept of contact-mediated quenching between doxorubicin a coumarin derivative.