A5022837486- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Gut microbiota and health
- Luminescence and Fluorescent Materials
- Virus-based gene therapy research
- Supramolecular Self-Assembly in Materials
- Clostridium difficile and Clostridium perfringens research
- Advanced Nanomaterials in Catalysis
- Food Allergy and Anaphylaxis Research
- Porphyrin and Phthalocyanine Chemistry
- Infectious Diseases and Tuberculosis
- Toxin Mechanisms and Immunotoxins
- Bone Tissue Engineering Materials
- Cancer Immunotherapy and Biomarkers
- Peripheral Neuropathies and Disorders
- Cancer Research and Treatments
- Electrowetting and Microfluidic Technologies
- Plant-derived Lignans Synthesis and Bioactivity
- Dendrimers and Hyperbranched Polymers
- Microscopic Colitis
- CAR-T cell therapy research
- Solar-Powered Water Purification Methods
China Pharmaceutical University
2024-2025
University of Michigan
2019-2024
BioSurfaces (United States)
2022-2024
State Key Laboratory of Natural Medicine
2024
Weifang University
2024
Union Hospital
2018-2024
Jilin University
2018-2024
University of Twente
2020
Huazhong Agricultural University
2015-2019
Nanfang Hospital
2018
A novel dual-pH sensitive charge-reversal strategy is designed to deliver antitumor drugs targeting tumor cells and further promote the nuclei internalization by a stepwise response mildly acidic extracellular pH (≈6.5) of endo/lysosome (≈5.0). Poly(l-lysine)-block–poly(l-leucine) diblock copolymer synthesized lysine amino residues are amidated 2,3-dimethylmaleic anhydride form β-carboxylic amide, making polypeptides self-assemble into negatively charged micelles. The amide can be hydrolyzed...
In this paper, a self‐delivery system PpIX‐PEG‐(KLAKLAK) 2 (designated as PPK) is fabricated to realize mitochondria‐targeted photodynamic tumor therapy. It found that the PPK exhibited high drug loading efficacy well novel capacity in generation of intracellular reactive oxygen species (ROS). This study also indicated photochemical internalization effect photosensitizer protoporphyrin IX (PpIX) under short time light irradiation improved cellular PPK. On contrary, could target subcellular...
Photodynamic therapy faces the barrier of choosing appropriate irradiation region and time. In this paper, a matrix metalloproteinase-2 (MMP-2) responsive ratiometric biosensor was designed synthesized for aggregation-induced emission (AIE)-guided precise photodynamic therapy. It found that presented MMP-2 AIE behavior. Most importantly, it could accurately differentiate tumor cells from healthy by fluorescence ratio between freed tetraphenylethylene protoporphyrin IX (PpIX, internal...
Photodynamic therapy suffers from poor tumor selectivity and therapeutical efficacy. In this paper, an amphiphilic chimeric peptide is fabricated to realize sequential acidity‐responsive tumor‐targeted transport of photosensitizer in situ photodynamic nuclei. vitro studies demonstrate that the acidic microenvironment successfully sheds mask cationic nuclear localization sequence (NLS) negatively charged peptide. This charge reversal remarkably accelerates cellular uptake cells maximizes...
Geometrical shape of nanoparticles plays an important role in cellular internalization. However, the applicability tumor selective therapeutics is still scarcely reported. In this article, we designed a extracellular acidity-responsive chimeric peptide with geometrical switch for enhanced internalization and photodynamic therapy. This could self-assemble into spherical at physiological condition. While acidic microenvironment, underwent detachment acidity-sensitive 2,3-dimethylmaleic...
In this study, a pH sensitive chimeric peptide is developed to codeliver photosensitizer, protoporphyrin IX (PpIX), and plasmid DNA simultaneously. the presence of matrix metalloproteinase‐2 (MMP‐2), undergoes process hydrolysis PLGVR sequence, exfoliation PEG, increase positive charges. As result, can be preferentially uptaken by MMP‐2 rich tumor cells. To realize synergistic effect drug gene delivery, dual‐stage light irradiation strategy developed, i.e., short time efficiently enhance...
In this paper, an activable cell-penetrating peptide (CR8G3PK6, ACPP) with a shielding group of 2,3-dimethylmaleic anhydride (DMA) was conjugated antitumor drug doxorubicin (DOX) to construct novel prodrug (DOX-ACPP-DMA) for tumor targeted delivery. The DMA linked the primary amines K6 through amide bond used block function polycationic CPP (R8) intramolecular electrostatic attraction at physiological pH 7.4. At extracellular 6.8, hydrolysis led charge reversal, activating pristine improved...
Photodynamic therapy as a local therapeutic method shows great biocompatibility in tumor therapy. However, the poor accumulation of photosensitizer tumors restricted efficacy. Different from traditional chemotherapeutic drugs, some additional issues will further decrease photodynamic efficacy including oxygen concentration and short half life reactive species. Nanoparticles drug carriers are currently under rapid development for therapy, especially This review mainly focuses on design...
A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter macromolecular drugs would be released in presence of MMP tumor cells. This will find great potential as a novel chemotherapeutic combination cancer treatment.
Ignored damage in adjacent normal tissue is fatal especially some specific tumor therapy such as brain tumors, but it remains a great challenge to conquer due random drug diffusion and complexity. Herein, we show that hyperthermia mitochondria, an interparticle plasmonic coupling effect activated nanoevent, selectively strikes tissues without damaging tissues. Spherical gold nanoparticles with mitochondria-targeting moiety, triphenyl phosphonium, preferentially accumulated inside...
In this report, an amphiphilic mitochondria-targeted chimeric peptide-based drug delivery system (DDS) was designed to overcome resistance. vitro studies revealed that peptide could encapsulate doxorubicin (DOX) with high efficacy and target tumor mitochondria, realizing controlled release of DOX in situ photodynamic therapy (PDT) mitochondria. Importantly, reactive oxygen species (ROS) during PDT significantly disrupted leading a dramatic decrease intracellular adenosine 5'-triphophate...
Photodynamic therapy as a non-invasive approach has obtained great research attention during the last decade.
A catalase and oxidase-mimetic Pt nanozyme was developed demonstrated good drug resistance reversal ability.
Abstract Both excess dosages of drug and unwanted carrier can lead to severe side effects as well the failure tumor therapy. Here, an Fe 3+ –gallic acid based delivery system is designed for efficient monitoring release in tumor. polyphenol gallic form polygonal nanoscale coordination polymer aqueous solution, which exhibits certain antitumor effect. Importantly, this possesses extremely high doxorubicin (DOX) loading efficacy (up 48.3%). In vitro studies demonstrate that fluorescence DOX be...
Abstract Allergic diseases with high recurrence rates have severely threatened human health around the world. Several strategies been developed including administration of allergens or neutralizing antibodies, while allergen‐specific immunotherapy (AIT) has considered as a cure for allergic diseases. However, AIT some drawbacks anaphylactic side effects native allergen protein during therapy, poor biodistribution in targeted organs/cells, and unsatisfactory desensitization long‐term...
A versatile gold nanoparticle-based multifunctional RB-DEVD-AuNP-DTP has been developed to induce the targeted apoptosis of cancer cells and image in real time progress apoptosis. The nanoparticles were demonstrated have ability initiate mitochondria-dependent activate caspase-3 for real-time imaging progression
In this work, a new type of gold nanoparticles (AuNPs) is designed to achieve the programmed tumor imaging and light manipulated controlled drug release. vitro results demonstrate that these AuNPs undergo matrix metalloproteinase-2 (MMP-2) responsive fluorescence recovery photosensitizers, protoporphyrin IX (PpIX), in region, which can differentiate cells from healthy ones. Subsequently, irradiation activates PpIX, cleaves reactive oxygen species (ROS) sensitive thioketal linker, leading...