A5102005929- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cardiac Imaging and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Phagocytosis and Immune Regulation
- Food Allergy and Anaphylaxis Research
- Animal Disease Management and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Acute Myocardial Infarction Research
- Ubiquitin and proteasome pathways
- Asthma and respiratory diseases
- Medical Device Sterilization and Disinfection
- Vector-Borne Animal Diseases
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Vascular Tumors and Angiosarcomas
- Advanced biosensing and bioanalysis techniques
University of Michigan
2023-2024
Seoul National University
2004-2024
BioSurfaces (United States)
2024
Chungnam National University
2024
Convergent Science (United States)
2024
Seoul National University Bundang Hospital
2006-2018
University of California, San Diego
2010-2018
Chonnam National University
2016
CHA Gangnam Medical Center
2014
New Generation University College
2010
Immune-cell-derived membranes have garnered significant attention as innovative delivery modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and superior biocompatibilities. Integrating additional parental cell or synthetic lipid vesicles into cellular can further potentiate capacities to perform combinatorial pharmacological activities activating antitumor immunity, thus providing insights the potential of hybrid versatile vehicles immunotherapy. Here,...
Triple-negative breast cancer (TNBC) is characterized by its highly heterogeneous microenvironment and propensity for aggressive behavior, both of which represent, along with poor prognosis high incidence relapse, the main challenges curing disease. Although recent progress in targeted chemotherapy combinations has shown promising outcomes, conventional chemotherapeutic approaches have relied on exploiting expression certain molecules or proteins overexpressed cells as drug targets,...
Abstract Tumor heterogeneity is associated with the therapeutic failures of targeted therapies. To overcome such heterogeneity, a novel therapy proposed that could kill tumor populations diverse phenotypes by delivering nonselective cytotoxins to target‐positive cells as well surrounding via recurrent bystander killing effect. A representative prodrug prepared targets integrin αvβ3 and releases upon entering or caspase‐3. This allows αvβ3‐positive upregulate caspase‐3, which in turn,...
Despite recent breakthroughs in the development of direct KRAS inhibitors and modulators, no drugs targeting pan-KRAS mutant cancers are clinically available. Here, we report a novel strategy to treat using caspase-3 cleavable peptide–drug conjugate that exploits enhanced albumin metabolism altered deliver cytotoxic agent can induce widespread bystander killing effect tumor cells. Increased cancer cells induced apoptosis via intracellular uptake albumin-bound MPD1. This allowed upregulation...
Here we report a novel combination of caspase-cleavable peptide-doxorubicin conjugate (MPD-1) with CD47-antagonizing nanocage therapeutics for the treatment microsatellite-stable (MSS) colorectal cancer (CRC). MPD-1 (i) upregulated markers immunogenic cell death (ICD) in tumor, and increased co-stimulatory on dendritic cells (DCs), (ii) enhanced CD8+ T infiltration antigen presenting (APC) activation, (iii) showed negligible off-target immune-related toxicity compared to free dox. Then, CD47...
While conventional approaches for PTEN-loss cancers mainly focus on turning off growth promoting process through modulation of PI3K/AKT pathways, no effective therapeutic treatments that target cancer cells have yielded results. Moreover, targeted therapies, which are potent against only a subset with limited specificity, bring temporary response. Here, we report the development albumin-binding caspase-3 cleavable peptide-drug conjugate (PDC), utilizes enhanced albumin metabolism pathway in...
Oxidative stress, and in particular oxidation of lipoproteins, is a hallmark atherosclerosis. Upon entry lipoproteins into the vessel wall, cascade pro-atherogenic pathways initiated whereby reaction reactive oxygen species with substrates amenable to oxidation, such as polyunsaturated fatty acids, generates variety oxidation-specific epitopes on proteins apoptotic macrophages. Several these have been well characterized specific murine fully human antibodies generated our laboratory detect...
The selective cytotoxicity of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) to cancer cells but not normal makes it an attractive candidate for therapeutics. However, the disadvantages TRAIL such as physicochemical instability and short half-life limit its further clinical applications. In this study, was encapsulated into a novel anti-angiogenic nanocomplex both improved drug distribution at site enhanced anti-tumor efficacy. A prepared firstly by entrapping PEG-low...
Chemotherapy have commonly been used in maximum tolerated dose to completely eradicate the cancer. However, such treatments often failed due complex and dynamic nature of Therefore, it has suggested that cancer should be treated as a chronic disease, controlling its growth by providing continuous therapeutic pressure for long‐term. Such an approach, however, requires therapy is non‐toxic orally available with sufficient potency. Herein, we propose radiotherapy‐assisted metronomic...
Background and Objectives：Oxidative stress plays an important role in the pathogenesis of coronary atherosclerosis spasm. We investigated whether polymorphisms two oxidative stress-related genes, paraoxonase p22phox, are associated with risks artery spasm stenosis. Subjects Methods：The study comprised 116 patients variant angina, 118 stenosis 117 control subjects, who were all classified by angiography. In three groups, genotype frequencies Q192R polymorphism gene C242T p22phox analyzed,...
Background and Objectives:The achievement of maximal vasodilatation is mandatory for obtaining valid measurements the coronary flow reserve (CFR) fractional (FFR). Recent studies have indicated that an incremental dose or a high adenosine necessary to achieve hyperemia. We performed this study examine response physiologic parameters different doses methods administration in Koreans. Subjects Methods:CFR: The CFR was measured 25 consecutive patients with angiographically normal arteries by...
African swine fever (ASF), a contagious and lethal haemorrhagic disease of domestic pigs wild boars, poses significant threat to the global pig industry. Although experimental vaccine candidates derived from naturally attenuated, genetically engineered, or cell culture-adapted ASF virus have been tested, no commercial is accepted globally. We developed safe effective cell-adapted live attenuated candidate (ASFV-MEC-01) by serial passage field isolate in CA-CAS-01-A cells. ASFV-MEC-01,...
SUMMARY An acid-labile interferon-α (IFN-α) exists in IFN produced human peripheral leukocytes with Sendai virus. This activity was found fractions of molecular weights about 100 000 (100K), 58K and 44K. The the 100K fraction neutralized anti-HuIFN-α serum alone, but 44K only by a mixture anti-HuIFN-β sera.