A5067783329- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- Histiocytic Disorders and Treatments
- Extracellular vesicles in disease
- Microscopic Colitis
- Inflammasome and immune disorders
- Cutaneous Melanoma Detection and Management
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Phagocytosis and Immune Regulation
- 3D Printing in Biomedical Research
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Preterm Birth and Chorioamnionitis
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Nonmelanoma Skin Cancer Studies
- Pluripotent Stem Cells Research
- Chemotherapy-related skin toxicity
- Neuroscience and Neural Engineering
- Ubiquitin and proteasome pathways
- COVID-19 Clinical Research Studies
- Mitochondrial Function and Pathology
- Pregnancy-related medical research
- Mathematical Biology Tumor Growth
Henry Ford Health System
2020-2025
Wayne State University
2020-2025
Michigan United
2021-2022
Johns Hopkins Medicine
2018-2021
Johns Hopkins University
2017-2021
University of Pittsburgh
2017
Vaginally delivered nanoformulations of progesterone and histone deacetylase inhibitors prevent inflammation-induced preterm birth in mice.
Abstract Background Hidradenitis Suppurativa (HS) is a chronic inflammatory skin condition with greater prevalence and disease burden in patients who identify as African American those family history of HS, suggesting strong genetic component to its pathogenesis. Objective To evaluate the relationship between plasma protein expression, HS severity, ancestry diverse cohort Suppurativa. Methods We performed case-control study compared age-, sex-, ethnicity-matched healthy controls. profiled...
A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural functional changes in the central nervous system (CNS), resulting long-term sequelae. An improved understanding pathogenesis these is important for developing efficacious interventions. Human induced pluripotent stem cells (hiPSCs) offer an extraordinary window modeling pathogen-CNS interactions, other cellular three-dimensional (3D) neuronal cultures that...
Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune lack mRNA expression both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2 TMPRSS2 protein circulating exosomes contain significant protein. Upon ex vivo TLR4/7/8 stimulation, was quickly translocated to the monocyte cell surface independently transcription, while translocation...
Abstract Tumor heterogeneity is associated with the therapeutic failures of targeted therapies. To overcome such heterogeneity, a novel therapy proposed that could kill tumor populations diverse phenotypes by delivering nonselective cytotoxins to target‐positive cells as well surrounding via recurrent bystander killing effect. A representative prodrug prepared targets integrin αvβ3 and releases upon entering or caspase‐3. This allows αvβ3‐positive upregulate caspase‐3, which in turn,...
Abstract Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by lesions with CD1a‐positive/Langerin (CD207)‐positive histiocytes and inflammatory infiltrate that can cause local tissue damage systemic inflammation. Clinical presentations range from single minimal impact to life‐threatening disseminated disease. Therapy for LCH has been established through serial trials empirically testing different chemotherapy agents durations of therapy. However, fewer than...
Hepatocellular carcinoma (HCC) is the sixth most common and fourth deadly cancer worldwide. The development cost of new therapeutics a major limitation in patient outcomes. Importantly, there paucity preclinical HCC models which to test small molecules. Herein, we implemented potentially novel patient-derived organoid (PDO) xenografts (PDX) strategies for high-throughput drug screening. Omacetaxine, an FDA-approved chronic myelogenous leukemia (CML), was found be top effective molecule PDOs....
Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations been made. lack knowledge regarding intersection genetics, immunology environmental...
Induced pluripotent stem cell (iPSC)-based technologies offer an unprecedented possibility to investigate defects occurring during neuronal differentiation in neuropsychiatric and neurodevelopmental disorders, but the density intricacy of intercellular connections cultures challenge currently available analytic methods. Low-density facilitate morphometric functional analysis neurons. We describe a protocol generate low-density (∼2,500 neurons/cm2) from human iPSC-derived neural cells/early...
Abstract Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasm that develops due to dysregulated dendritic (DC) development and most commonly affects the children with incidence of 2.6 8.9 cases per million individuals year. BRAFV600E, common disease-driving mutation, activates mitogen-activated protein kinase (MAPK) pathway causing pathognomonic features lead accumulation LCH cells formation granulomatous lesions. These include enhanced myelopoiesis, reduced tissue-egress...
Histiocytic diseases arise from MAPK mutations in myeloid progenitors. Depending on whether the progenitor follows a dendritic cell or macrophage/monocyte lineage final histology results Langerhans histiocytosis, Rosai–Dorfman disease Erdheim–Chester disease. Commentary on: Friedman et al. Mixed histiocytic neoplasms: A multicentre series revealing diverse somatic and responses to targeted therapy. Br J Haematol 2024;205:127–137.