A5091482499- Hidradenitis Suppurativa and Treatments
- Colorectal and Anal Carcinomas
- melanin and skin pigmentation
- Inflammasome and immune disorders
- Chemotherapy-related skin toxicity
- Microscopic Colitis
- Acne and Rosacea Treatments and Effects
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Atherosclerosis and Cardiovascular Diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Anorectal Disease Treatments and Outcomes
- Autoimmune and Inflammatory Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Advanced Drug Delivery Systems
- Genetic and rare skin diseases.
- Horticultural and Viticultural Research
- Nonmelanoma Skin Cancer Studies
- Cutaneous Melanoma Detection and Management
Henry Ford Health System
2021-2024
Henry Ford Hospital
2018-2024
Michigan United
2021
Wayne State University
2017-2020
Kresge Eye Institute
2017
Melasma is an acquired pigmentation disease that mainly involves the development of symmetrical yellow-brown facial patches. The incidence rate increasing yearly. Therefore, actively studying exposure factors induce melasma could contribute to prevention and treatment this disease. In present review, possible were summarized.
Hidradenitis suppurativa (HS) is a multifactorial chronic skin disease characterized by inflammation around the hair follicles commonly affecting intertriginous areas. The underlying pathogenesis of HS and its molecular mechanisms are largely understudied. Genetic studies in families have identified variants within γ-secretase complex associated with HS; however, no definitive genotype-phenotype correlations been made. lack knowledge regarding intersection genetics, immunology environmental...
Introduction: Dry eye disease (DED) is an important public health problem considering its prevalence, morbidity, and cost implications. In the last two decades, new insight on pathogenesis of dry has resulted in development novel therapeutic modalities.Areas covered: This review will discuss current emerging pharmacological modalities treatment DED to include tear supplements, anti-inflammatory therapy, antibiotics, vitamin A, other vitamins antioxidants, free amino acids, essential fatty...
Hidradenitis suppurativa (HS), psoriasis, and vitiligo are chronic, immune-mediated skin diseases with a significant quality-of-life burden. Individuals these conditions thought to be at increased risk of lymphoma,1-3 several cases have been reported in the context adalimumab treatment, raising concern for its use at-risk patients. The specific mechanisms underlying link between chronic inflammatory states neoplastic transformation largely unknown, most data on topic come from outside...
Abstract Hidradenitis suppurativa (HS), an inflammatory skin-disease, manifests as painful lesions in intertriginous skin. Despite their central role innate immunity the of monocytes HS is largely unknown. Here we utilized cytometry by time-of-flight (CyTOF), imaging CyTOF (IMC), cellular indexing transcriptomes and epitopes sequencing (CITEseq), spatial transcriptomics (ST), our recently developed database (HSOmicsDB) to characterize systemic cutaneous immune response patients with HS....
The incidence of oropharyngeal cancer (OPC) has increased in the United States. This been driven by an increase human papillomavirus (HPV)-positive OPC. Our objective is to determine trends National Institutes (NIH)-supported research funding and public interest OPC.The NIH Research Portfolio Online Reporting Tools database was evaluated for projects related OPC between 2004 2015. Projects were total funding, relation HPV, principal investigator departmental affiliation degree, agency or...
Background Postinflammatory hyperpigmentation (PIH) is a common, acquired pigmentary disorder of the skin associated with significant quality-of-life impairment, especially in individuals colour. Current treatment for PIH limited, largely due to poor understanding disease pathogenesis and lack representative model. Objectives This study intended further develop, update validate our previously designed vivo model acne-induced PIH/postinflammatory erythema (PIE) using different concentrations...
Abstract: Microsecretory adenocarcinoma (MSA) was first described in 2019 as a low-grade salivary gland neoplasm of intraoral origin with distinct histopathologic features and characteristic MEF2C::SS18 fusion. Recently, skin also identified primary site for MSA report by Bishop et al. Due to its rarity resemblance other adnexal tumors, is challenging diagnosis. Herein, we present case cutaneous that unique the presence significant microcystic component marked hyperplasia, which mimicked...
Introduction: Dry eye disease (DED) is a multifactorial condition of the tears and ocular surface. New insight on pathogenesis dry has resulted in development novel treatments. Current management paradigms vary from self-administered (e.g. artificial tears) to practitioner-administered punctal occlusion) modalities.Areas covered: In part A this series, spectrum pharmacological agents for treatment DED was reviewed. Part B discusses current emerging non-pharmacological therapeutic modalities,...
Hidradenitis suppurativa (HS) is a multifactorial, inflammatory skin disease. Increased systemic comorbidities and serum cytokines highlight inflammation as feature of HS. However, the specific immune cell subsets contributing to cutaneous have not been resolved.Identify features peripheral dysregulation.Here, we generated whole-blood immunomes by mass cytometry. We performed meta-analysis RNA-seq data, immunohistochemistry, imaging cytometry characterize immunological landscape lesions...
Abstract Hidradenitis suppurativa (HS) is a multifactorial, inflammatory skin disease. Increased systemic comorbidities and serum cytokines highlight inflammation as feature of HS. However, the specific immune cell subsets contributing to cutaneous have not been resolved. Here, we generated whole-blood immunomes by mass cytometry. We performed meta-analysis RNA-seq data, immunohistochemistry, imaging cytometry characterize immunological landscape lesions perilesions from patients with Blood...