A5079917691- Retinoids in leukemia and cellular processes
- Skin Protection and Aging
- Legume Nitrogen Fixing Symbiosis
- melanin and skin pigmentation
- Agronomic Practices and Intercropping Systems
- Cancer-related Molecular Pathways
- Photodynamic Therapy Research Studies
- Vitamin C and Antioxidants Research
- Genomics, phytochemicals, and oxidative stress
- PI3K/AKT/mTOR signaling in cancer
- Estrogen and related hormone effects
- Hidradenitis Suppurativa and Treatments
- Pesticide Exposure and Toxicity
- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Antioxidant Activity and Oxidative Stress
- Cancer Research and Treatments
- Heavy Metal Exposure and Toxicity
- Inflammatory mediators and NSAID effects
- Agricultural Science and Fertilization
- Nonmelanoma Skin Cancer Studies
- Colorectal and Anal Carcinomas
- Phytochemicals and Antioxidant Activities
- Sulfur Compounds in Biology
- Arsenic contamination and mitigation
University of Alabama at Birmingham
2016-2025
Birmingham VA Medical Center
2013-2025
Indian Agricultural Research Institute
2023
PricewaterhouseCoopers (South Korea)
2022
Jawaharlal Institute of Post Graduate Medical Education and Research
2022
Aligarh Muslim University
2022
University of Alabama
2011-2021
California Department of Food and Agriculture
2011-2020
University of Karachi
2013-2020
Instituto de Salud Carlos III
2018
Cancer genomic, transcriptomic, and proteomic profiling has generated extensive data that necessitate the development of tools for its analysis dissemination. We developed UALCAN to provide a portal easy exploring, analyzing, visualizing these data, allowing users integrate better understand gene, proteins, pathways perturbed in cancer make discoveries. web enables analyzing delivering transcriptome, proteomics, patient survival research community. With obtained from The Genome Atlas (TCGA)...
Glutathione (GSH) plays several important roles in the protection of cells against oxidative damage, particularly following exposure to xenobiotics. Ferric nitrilotriacetate (Fe-NTA) is a potent depletor GSH and also enhances tissue lipid peroxidation. In this study, we show effect Fe-NTA treatment on hepatic some glutathione metabolizing enzymes, oxidant generation liver damage. The level activities reductase, S-transferase, peroxidase, glucose 6-phosphate dehydrogenase all decrease...
Abstract The present study was designed to investigate the protective efficacy of eugenol against skin cancer and probe into mechanistic aspects. Skin tumors were initiated by applying 160 nmol DMBA promoted twice weekly applications 8.5 TPA for 28 wk. All mice developed 13 wk promotion. However, in pretreated with 30 µL eugenol, no detected until 8 (following anti‐initiation protocol) 14 antipromotion tumor PCNA TUNEL immunohistochemistry revealed ameliorate cell proliferation elevate...
Malignant melanoma is responsible for approximately 75% of skin cancer-related deaths. BRAF plays an important role in regulating the mitogen-activated protein kinase (MAPK) signaling cascade with activating mutations serine/threonine occurring 60-70% malignant melanomas. The BRAF-MEK-ERK pathway a key regulator cell invasion. In addition, activation NFκB via MAPK regulated through MEK-induced IKK. These pathways are potential targets prevention and treatment melanoma. this study, we...
Cd/CB-induced citrullinated vimentin promotes PAD2- and TLR4-dependent lung fibrosis.
Idiopathic pulmonary fibrosis (IPF) is a progressive disease, with median survival of 3–5 years following diagnosis. Lung remodeling by invasive fibroblasts hallmark IPF. In this study, we demonstrate that inhibition vimentin intermediate filaments (VimIFs) decreases the invasiveness IPF and confers protection against in murine model experimental lung injury. Increased expression organization VimIFs contribute to property connection deficient cellular autophagy. Blocking VimIF assembly...
Inflammatory stimuli result in the production of cutaneous eicosanoids, which are known to contribute process tumor promotion. Cyclooxygenase (COX), rate-limiting enzyme for prostaglandins (PG) from arachidonic acid, exists at least two isoforms, COX-1 and COX-2. is constitutively expressed most tissues plays various physiological roles, whereas increased COX-2 expression occur several types epithelial neoplasms. Enhanced PG synthesis a potential contributing factor UVB-induced nonmelanoma...
Ferric nitrilotriacetate (Fe-NTA) is a known complete renal carcinogen. In this study we show that Fe-NTA potent inducer of ornithine decarboxylase (ODC) activity and DNA synthesis promoter N-diethylnitrosamine (DEN)-induced tumorigenesis in rat. induced ODC several fold as compared with saline-treated rats. Renal synthesis, measured [3H]thymidine incorporation into DNA, was increased after treatment. Similar to other tumor promoters, also depleted the antioxidant armory tissue. It...
Mutations in the tumor suppressor p53 are detectable over 50% of all human malignancies. Mutant protein is incapable transactivating its downstream target genes that required for DNA repair and apoptosis. Chronic exposure to UVB induces mutations carcinogenic both murine skin. CP-31398, a styrylquinazoline compound, restores functions mutant forms cells. However, effectiveness vivo remains unclear. Here, we demonstrate CP-31398 blocked UVB-induced skin carcinogenesis was associated with...