A5012495384- Cancer-related molecular mechanisms research
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Pediatric health and respiratory diseases
- Air Quality and Health Impacts
- Cell Adhesion Molecules Research
- RNA modifications and cancer
- Extracellular vesicles in disease
- Protease and Inhibitor Mechanisms
- Cell death mechanisms and regulation
- Smoking Behavior and Cessation
- HIV Research and Treatment
- Indoor Air Quality and Microbial Exposure
- COVID-19 Clinical Research Studies
- Asthma and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Nanoparticle-Based Drug Delivery
- Fibroblast Growth Factor Research
- IL-33, ST2, and ILC Pathways
- Growth Hormone and Insulin-like Growth Factors
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
Florida International University
2016-2023
Lovelace Respiratory Research Institute
2010-2018
University of New Mexico
2003-2010
Institute of Infection and Immunity
2008
University of Delhi
2000-2005
The blood-brain barrier (BBB) is a main obstacle for drug delivery targeting the central nervous system (CNS) and treating Alzheimer's disease (AD). In order to enhance efficiency of without harming BBB integrity, nanoparticle-mediated has become popular therapeutic strategy. Carbon dots (CDs) are one most promising novel nanocarriers. this study, amphiphilic yellow-emissive CDs (Y-CDs) were synthesized with an ultrasonication-mediated methodology using citric acid o-phenylenediamine size 3...
New emerging tobacco products, especially electronic cigarettes (E-Cig) or nicotine delivery systems (ENDS), have gained a huge popularity, particularly in younger populations. The lack of sufficient evidence-based health effect studies has promoted widespread use/abuse with the assumption that E-Cig ENDS and/or vaping products are safer and less toxic than conventional smoking. However, recent escalation acute lung injuries their associated fatalities among product users now brought...
Chronic obstructive pulmonary disease (COPD) and idiopathic fibrosis (IPF) are chronic, progressive lung ailments that characterized by distinct pathologies. Early detection biomarkers mechanisms for these debilitating diseases lacking. Extracellular vesicles (EVs), including exosomes, small, lipid-bound attributed to carry proteins, lipids, RNA molecules facilitate cell-to-cell communication under normal diseased conditions. Exosomal miRNAs have been studied in relation many diseases....
A magnetically guided brain delivery method previously demonstrated in mice has not yet been translated for clinical applications due to the mismatch of available static magnet dimensions relation human size and shape. To develop a human-compatible methodology, we explored magnetic resonance imaging (MRI) as tool magneto-electric nanoparticles (MENPs) into baboon, proof-of-concept study. MRI image analysis showed reduction T2* value at basal ganglia, hemisphere, vertex, thereby confirming...
Human tissue factor pathway inhibitor-2 (TFPI-2) is a Kunitz-type proteinase inhibitor that regulates variety of serine proteinases involved in coagulation and fibrinolysis through their non-productive interaction with P1 residue (Arg-24) its first domain (KD1). Previous kinetic studies revealed TFPI-2 was more effective plasmin than several other proteinases, but the molecular basis for this specificity unclear. In study, we employed modeling mutagenesis strategies to produce variants human...
Interferon γ (IFN-γ)–induced cell death is mediated by the BH3-only domain protein, Bik, in a p53-independent manner. However, effect of IFN-γ on p53 and how this affects autophagy have not been reported. The present study demonstrates that down-regulated expression BH3 domain-only Bmf, human mouse airway epithelial cells p53-dependent also suppressed Bmf response to other death–stimulating agents, including ultraviolet radiation histone deacetylase inhibitors. did affect messenger RNA...
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Abstract Embryonic development is highly sensitive to xenobiotic toxicity and in utero exposure environmental toxins affects physiological responses of the progeny. In United States, prevalence allergic asthma (AA) inexplicably rising cigarette smoke increases risk AA bronchopulmonary dysplasia (BPD) children animal models. We reported that gestational sidestream (SS), or secondhand smoke, promoted nicotinic acetylcholine receptor–dependent exacerbation BPD mice. Recently, perinatal nicotine...
Abstract Combination antiretroviral therapy (cART) has increased the life expectancy of HIV patients. However, incidence non-AIDS associated lung comorbidities, such as COPD and asthma, that opportunistic infections have become more common among this population. proteins secreted by anatomical reservoirs can both autocrine paracrine effects contributing to HIV-associated comorbidities. been recovered from cell-free bronchoalveolar lavage fluid, alveolar macrophages, intrapulmonary...
Ulcerative colitis (UC) is a Th2 inflammatory bowel disease characterized by increased IL-5 and IL-13 expression, eosinophilic/neutrophilic infiltration, decreased mucus production, impaired epithelial barrier, bacterial dysbiosis of the colon. Acetylcholine nicotine stimulate production suppress inflammation through nicotinic receptors in lungs but UC rarely observed smokers mechanism protection unclear.
The emerging field of theranostics for advanced healthcare has raised the demand effective and safe delivery systems consisting therapeutics diagnostics agents in a single monarchy. This requires development multi-functional bio-polymeric efficient image-guided therapeutics. study reports size-controlled (micro-to-nano) auto-fluorescent biopolymeric hydrogel particles chitosan hydroxyethyl cellulose (HEC) synthesized using water-in-oil emulsion polymerization technique. Sustainable resource...
Cigarette smoke (CS) exposure is strongly associated with chronic obstructive pulmonary disease (COPD). In respiratory airways, CS disrupts airway barrier functions, mucous/phlegm production, and basic immune responses of epithelial cells. Based on our recent identification a specific immunomodulatory long noncoding RNA (lncRNA), we investigated its role in CS-induced bronchial airways cynomolgus macaque model COPD former smokers without COPD. The lncRNA was significantly upregulated that...
Abstract Tissue factor (TF) is a transmembrane glycoprotein that serves as the prime initiator of blood coagulation and plays critical role in thrombosis hemostasis. In addition, variety tumor cells overexpress cell‐surface TF, which appears to be important for angiogenesis metastasis. To elucidate mechanism involved upregulation TF human cells, comprehensive analysis mRNA from various normal was performed. The results these studies indicate that, addition possessing full‐length transcript...